Results 21 to 30 of about 14,789,955 (251)

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Blood, 2021
Silasi et al report new data on the role of factor XII in systemic inflammation and pathological coagulation induced by systemic inactivated Staphylococcus aureus in baboons.
R. Silasi, R. Keshari, G. Regmi, C. Lupu, C. Georgescu, J. Simmons, M. Wallisch, T. Kohs, J. Shatzel, S. Olson, Christina U. Lorentz, C. Puy, Erik I. Tucker, D. Gailani, S. Strickland, A. Gruber, O. McCarty, F. Lupu   +17 more
semanticscholar   +1 more source

Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting

Journal of Neuroanaesthesiology and Critical Care, 2020
Factor XII deficiency is a rare disorder that can complicate the perioperative management of a patient. Factor XII plays an important role in the activation of intrinsic pathway of coagulation; the deficiency, therefore, results in prolongation of ...
Mouleeswaran Sundaram, Sonia Bansal, Rohini M. Surve   +2 more
doaj   +1 more source

Establishment of the World Health Organization First International Standard for Factor XII, Plasma, Human

Frontiers in Medicine, 2018
Until recently, the role of factor XII (FXII) in hemostasis was not considered to be important since patients with FXII deficiency do not present with bleeding.
Helen V. Wilmot, Jason Hockley, Peter Rigsby, Elaine Gray   +3 more
doaj   +1 more source

The new era of anticoagulation: factor XI and XII inhibitors

Bleeding, Thrombosis and Vascular Biology, 2023
The two last decades have witnessed a revolution in the field of anticoagulation, mainly due to the advent of direct anticoagulant with targeted action against single coagulation proteins. However, the residual risk of cardio- and cerebrovascular events,
Domenico Prisco, Irene Mattioli, Raffaele De Caterina, Alessandra Bettiol   +3 more
doaj   +1 more source

Extracellular Vesicles Derived From Platelets, Red Blood Cells, and Monocyte-Like Cells Differ Regarding Their Ability to Induce Factor XII-Dependent Thrombin Generation

Frontiers in Cell and Developmental Biology, 2020
As transmitters of biological information, extracellular vesicles (EVs) are crucial for the maintenance of physiological homeostasis, but also contribute to pathological conditions, such as thrombotic disorders.
C. Tripisciano, R. Weiss, Sobha Karuthedom George, M. Fischer, V. Weber   +4 more
semanticscholar   +1 more source

Global cerebral infarction after aortic arch replacement surgery in a patient with postoperatively revealed factor XII deficiency: a case report

Journal of Medical Case Reports, 2020
Background This case report presents a case of a patient with global cerebral infarction of uncertain etiology following an emergency surgery for acute type A aortic dissection. As a result, factor XII deficiency was revealed postoperatively.
Keisuke Yoshida, Shiori Tanaka, Yuki Sato, Kazuhiro Watanabe, Kenichi Muramatsu, Masahiro Murakawa   +5 more
doaj   +1 more source

Factor XII (Hageman) Levels in Women with Recurrent Pregnancy Loss

Journal of Pregnancy, 2014
Objective. To evaluate factor XII levels in women with recurrent pregnancy loss (RPL) in a tertiary referral hospital. Methods. Women who were referred to our hospital for two consecutive abortions or three abortions in between 2007 and 2013 were ...
A. Seval Ozgu-Erdinc, Cihan Togrul, Ayla Aktulay, Umran Buyukkagnici, Elif Gul Yapar Eyi, Salim Erkaya   +5 more
doaj   +1 more source

Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis

TH Open, 2019
The contributions of coagulation factor XI (FXI) and FXII to human clot formation is not fully known. Patients with deficiency in FXI have a variable mild bleeding risk, whereas FXII deficiency is not associated with bleeding.
José W. P. Govers-Riemslag, Joke Konings, Judith M. E. M. Cosemans, Johanna P. van Geffen, Bas de Laat, Johan W. M. Heemskerk, Yesim Dargaud, Hugo ten Cate   +7 more
doaj   +1 more source

The contact system proteases play disparate roles in streptococcal sepsis

Haematologica, 2020
Sepsis causes an activation of the human contact system, an inflammatory response mechanism against foreign surfaces, proteins and pathogens. The serine proteases of the contact system, factor XII and plasma kallikrein, are decreased in plasma of septic ...
Juliane Köhler, Claudia Maletzki, Dirk Koczan, Marcus Frank, Carolin Trepesch, Alexey S. Revenko, Jeffrey R. Crosby, A. Robert Macleod, Stefan Mikkat, Sonja Oehmcke-Hecht   +9 more
doaj   +1 more source

Factor XII/XIIa inhibitors: Their discovery, development, and potential indications.

European journal of medicinal chemistry, 2020
Coagulation factor XII (FXII), a S1A serine protease, was discovered more than fifty years ago. However, its in vivo functions and its three-dimensional structure started to be disclosed in the last decade.
C. Davoine, Charlotte Bouckaert, M. Fillet, L. Pochet   +3 more
semanticscholar   +1 more source