Association Between Prekallikrein and Stroke: A Mendelian Randomization Study [PDF]
Journal of the American Heart Association, 2023 Background High plasma prekallikrein was reported to be associated with increased risks of stroke, but the causality for these associations remains unclear.
Yinan Wang +2 more
exaly +4 more sources
Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema [PDF]
CPT: Pharmacometrics & Systems PharmacologyHereditary angioedema (HAE) is a rare disorder linked to kallikrein‐kinin system dysregulation, which leads to uncontrolled activation of plasma prekallikrein.
John K. Diep +7 more
doaj +2 more sources
The involvement of proteoglycans in the human plasma prekallikrein interaction with the cell surface. [PDF]
PLoS ONE, 2014 INTRODUCTION: The aim of this work was to evaluate the role of human plasma prekallikrein assembly and processing in cells and to determine whether proteoglycans, along with high molecular weight kininogen (H-kininogen), influence this interaction ...
Camila Lopes Veronez +5 more
doaj +5 more sources
Exposure–Response Analysis of Donidalorsen for the Treatment of Hereditary Angioedema [PDF]
Clinical and Translational ScienceHereditary angioedema (HAE) is characterized by recurrent attacks of severe tissue swelling. In the OASIS‐HAE phase 3 study (NCT05139810), donidalorsen, an RNA‐targeted antisense oligonucleotide that reduces prekallikrein production in the liver ...
Pratap Singh +7 more
doaj +2 more sources
PREKALLIKREIN DEFICIENCY IN MAN [PDF]
Journal of Experimental Medicine, 1973 Blood plasma obtained from an individual with abnormal thromboplastin formation, due to deficiency of Fletcher factor, was fully corrected by 2% of normal, Hageman factor- or PTA-deficient plasma. It was also reconstituted by addition of highly purified human or rabbit prekallikrein. The plasma failed to generate kinin upon exposure to kaolin, a defect
K D Wuepper
exaly +3 more sources
Plasma Prekallikrein: Its Role in Hereditary Angioedema and Health and Disease
Frontiers in Medicine, 2018 Plasma prekallikrein (PK) has a critical role in acute attacks of hereditary angioedema (HAE). Unlike C1 inhibitor, its levels fall during HAE attacks with resultant cleaved high-molecular-weight kininogen.
Alvin H Schmaier
exaly +3 more sources
Alzheimer’s Disease: In Vitro and In Vivo Evidence of Activation of the Plasma Bradykinin-Forming Cascade and Implications for Therapy [PDF]
CellsThe plaques associated with Alzheimer’s disease are formed as a result of the aggregation of Aβ peptides, which vary in length from 38 to 43 amino acids.
Allen P. Kaplan +2 more
doaj +2 more sources
Double Trouble: Combined Prekallikrein and IgA Deficiencies in a Patient Undergoing Orthotopic Heart Transplantation—A Case Report [PDF]
Case Reports in AnesthesiologyPrekallikrein (PK) and selective IgA deficiencies are rare, and their coexistence in a cardiac transplant patient presents unique challenges. These disorders affect anticoagulation monitoring and transfusion safety, necessitating tailored perioperative ...
Brittany McLay +6 more
doaj +2 more sources
A monoclonal anti-human plasma prekallikrein antibody that inhibits activation of prekallikrein by factor XIIa on a surface [PDF]
Blood, 1987 Abstract Of five IgGI/k murine monoclonal anti-human prekallikrein antibodies produced (MAbs), MAb 13G11 was selected for studying interaction of prekallikrein with factor XII and high-mol-wt kininogen (HMWK) during activation on a surface.
D Veloso, Rw Colman
exaly +4 more sources
A novel anti-thrombotic mechanism mediated by the receptors of the kallikrein/kinin and renin-angiotensin systems [PDF]
Frontiers in Medicine, 2016 The contact activation (CAS) and kallikrein/kinin (KKS) systems regulate thrombosis risk two ways. First, the CAS influences contact activation-induced factor XI activation and thrombin formation through the hemostatic cascade.
Alvin H. Schmaier
doaj +4 more sources