Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells [PDF]
, 2013 Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2.
David, H +10 more
core +2 more sources
Factor XII – What's important but not commonly thought about
Research and Practice in Thrombosis and Haemostasis, 2019 Factor XII (FXII) becomes a serine protease when blood is exposed to artificial medical surfaces or when pathologic surfaces arise in disease states leading to its autoactivation.
Alvin H. Schmaier, Evi X. Stavrou
doaj +1 more source
Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans
Frontiers in Physiology, 2017 Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin. In the proximity of its target cells, high molecular weight kininogen (H-kininogen) is the substrate of plasma kallikrein, which releases bradykinin from H ...
Guacyara Motta, Ivarne L. S. Tersariol
doaj +1 more source
Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]
, 1994 To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Cheronis, John C. +7 more
core +2 more sources
Detection of surface-adsorbed (lipo)proteins by means of a two-step enzyme-immunoassay: a study on the Vroman effect [PDF]
, 1990 In view of reports on the involvement of high-molecular-weight (HMW) kininogen and high-density lipoprotein (HDL) in the Vroman effect, we studied the adsorption of fibrinogen, HMW kininogen, HDL and several other proteins from pooled human plasma and ...
Aken, W.G. van +3 more
core +2 more sources
Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update
Medicina, 2022 The aim of this review is to highlight all the factors that associate venous thromboembolism (VTE) with aging. Elderly people are characterized by a higher incidence of thrombosis taking into account the co-existing comorbidities, complications and ...
Dimitra Akrivou +4 more
doaj +1 more source
Mechanism and therapy of hereditary angioedema typ III and role of the contact system in inflammatory diseases [PDF]
, 2014 Combinations of proinflammatory and procoagulant reactions are associated with a variety of disorders affecting the cardiovascular system. Vascular leakage contributes to the pathology of conditions such as, sepsis, allergy and anaphylactic reactions ...
Björkqvist, Jenny
core +1 more source
Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
Frontiers in Physiology, 2023 Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight ...
Guacyara Motta +2 more
doaj +1 more source
AUTOACTIVATION OF HUMAN PLASMA PREKALLIKREIN
Thrombosis and Haemostasis, 1987 Incubation of purified human plasma prekallikrein with sulfatides or dextran sulfate resulted in spontaneous activation of prekallikrein as judged by the appearance of amidolytic activity towards the chromogenic substrate H-D-pro-phe-arg-p-nitroanilide (S 2302).
G, Tans +4 more
openaire +2 more sources
Switching Long‐Term Prophylaxis to Donidalorsen for Hereditary Angioedema: 1‐Year OASISplus Results
Allergy, EarlyView.This study evaluated the long‐term safety and efficacy of donidalorsen in patients who switched from a long‐term prophylactic treatment (LTP) to donidalorsen with 1‐year outcomes. Patients who switched from LTP to donidalorsen experienced a 67.6% reduction in HAE attack rates over 52 weeks.
Marc A. Riedl +16 more
wiley +1 more source