Results 21 to 30 of about 4,917 (213)
Lisinopril-Induced Angioedema in a Patient with Plasma Prekallikrein Deficiency
TH Open, 2020 Angiotensin-converting enzyme (ACE) inhibitors are extensively prescribed to treat patients with hypertension, congestive heart failure, and diabetic nephropathy.
Swapan K. Dasgupta +2 more
doaj +1 more source
PLoS ONE, 2023 Protection from the toxicity of nerve agents is achieved by pretreatment with human butyrylcholinesterase (BChE). Current methods for purifying large quantities of BChE from frozen Cohn fraction IV-4 produce 99% pure enzyme, but the yield is low (21 ...
Lawrence M Schopfer +3 more
doaj +1 more source
The complex role of kininogens in hereditary angioedema
Frontiers in Allergy, 2022 Human high molecular weight kininogen (HK) is the substrate from which bradykinin is released as a result of activation of the plasma “contact” system, a cascade that includes the intrinsic coagulation pathway, and a fibrinolytic pathway leading to the ...
Allen P. Kaplan +2 more
doaj +1 more source
Expression of the plasma prekallikrein gene: utilization of multiple transcription start sites and alternative promoter regions [PDF]
, 2005 The plasma prekallikrein gene is expressed in many different human tissues at distinctly different levels and therefore tissue-specific control of the gene transcription is likely.
Akita +12 more
core +1 more source
Diabetes, 2003 The relevance and significance of the plasma kallikrein/kinin system as a risk factor for the development of vascular complications in diabetic patients was explored in a cross-sectional study. We measured the circulating levels of plasma prekallikrein (PK) activity, factor XII, and high−molecular weight kininogen in the plasma of 636 type 1 diabetic ...
Ayad A. Jaffa +6 more
openaire +1 more source
Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]
, 1993 Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Fink, Edwin +8 more
core +1 more source
Expression of plasma prekallikrein mRNA in human nonhepatic tissues and cell lineages suggests special local functions of the enzyme [PDF]
, 1999 At present it is generally accepted that plasma prekallikrein (PPK) is synthesized in the liver and secreted into the bloodstream. Surprisingly, it has recently been shown that PPK mRNA is present also in RNA from the kidney, adrenal gland and placenta ...
Arnhold, Marianne +4 more
core +1 more source
Treatment of Hereditary Angioedema With Plasma-Derived C1 Inhibitor: A Review. [PDF]
Clin Transl AllergyABSTRACT Hereditary angioedema (HAE) is clinically characterized by recurrent episodes of localized edema. HAE typically occurs due to a deficiency of functional C1 inhibitor (C1INH, HAE‐C1INH); in addition, several types of HAE with normal quantity and activity of C1INH (HAE‐nC1INH) have recently been classified, which occur due to different gene ...
Martinez-Saguer I +3 more
europepmc +2 more sources
The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin [PDF]
, 2002 The influence of the hyaluronanbinding protease (PHBSP), a plasma enzyme with FVII- and pro-urokinase-activating potency, on components of the contact phase (kallikrein/kinin) system was investigated.
Beer, N. +4 more
core +1 more source
The isolation of human plasma prekallikrein [PDF]
British Journal of Pharmacology, 1970 Summary . The isolation of human plasma prekallikrein was achieved by fractionating human plasma on diethylaminoethyl cellulose (DEAE) in the presence of heparin. . Heparin was shown to inhibit the activation of prekallikrein during the isolation procedure. .
D J, McConnell, B, Mason
openaire +2 more sources