Results 11 to 20 of about 4,917 (213)
A model of zymogen factor XII: insights into protease activation [PDF]
Blood Advances: In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) to release bradykinin, which contributes to regulation of ...
Aleksandr Shamanaev +9 more
doaj +2 more sources
Genetic Analysis of Prekallikrein Deficiency in a Consanguineously Married Chinese Family [PDF]
Turkish Journal of Hematology, 2023 Yuan Chen +4 more
doaj +2 more sources
Bacterial infection and activation of the contact pathway of coagulation [PDF]
Blood Vessels, Thrombosis & Hemostasis: The excessive inflammatory and prothrombotic response to a bacterial infection creates a life-threatening medical condition in sepsis. The transition from localized to systemic thrombin generation is a hallmark of disseminated intravascular coagulation
André L. Lira +4 more
doaj +2 more sources
Биопрепараты: Профилактика, диагностика, лечение, 2022 Assessment of prekallikrein content is essential for safety control of human immunoglobulin and albumin products. The inherent variability of human prekallikrein reagents and chromogenic substrates indicates the need for standardisation of the ...
O. G. Kornilova +4 more
doaj +1 more source
Frontiers in Oncology, 2022 ObjectiveTumor-promoting inflammation is among the hallmarks of cancer. Prekallikrein is among the acute-phase reactants in the inflammatory response; moreover, neutrophils release nuclear contents into the extracellular space to create neutrophil ...
Jisoo G. Kim +10 more
doaj +1 more source
Hydrogels by irradiation of a synthetic heparinoid polyelectrolyte [PDF]
, 1983 Gamma irradiation of aqueous solutions of a synthetic heparinoid polyelectrolyte results in the formation of hydrogels, varying in water content and mechanical strength.
Bantjes, A. +5 more
core +14 more sources
Is there a role for bradykinin in cerebral malaria pathogenesis?
Frontiers in Cellular and Infection Microbiology, 2023 Malaria is a parasitic disease of global health significance and a leading cause of death in children living in endemic regions. Although various Plasmodium species are responsible for the disease, Plasmodium falciparum infection accounts for most severe
Alessandro de Sa Pinheiro +4 more
doaj +1 more source
A Case Report of Non-Neutralizing Acquired Factor V Inhibitor Mimicking Deficiency: Diagnostic Challenges and Therapeutic Implications. [PDF]
Case Rep HematolAcquired Factor V (FV) deficiency due to inhibitors is a rare coagulopathy that presents significant diagnostic and therapeutic challenges. We report the case of an 81‐year‐old male with persistent gross hematuria and severe coagulopathy, marked by prolonged prothrombin time (PT), activated partial thromboplastin time (aPTT), and critically low FV ...
Kalantri S +5 more
europepmc +2 more sources
A Pre-Albumin Activator of Prekallikrein [PDF]
The Journal of Immunology, 1970 Abstract Chromatography of human serum on diethylaminoethyl cellulose reveals five peaks having bradykinin-generating activity. Kallikrein is found in peak 1, Hageman factor is found overlapping peaks 2 and 3, and a prekallikrein activator is found in peaks 2 through 5.
A P, Kaplan, K F, Austen
openaire +2 more sources
Depressed Kallikrein Generation in Women With Preeclampsia: A Matched Cross-Sectional Study
Frontiers in Medicine, 2022 ObjectiveThe pathophysiology of preeclampsia is not fully understood. Disturbances in the contact system are associated with preeclampsia. Few studies have investigated the association between preeclampsia and alterations in the contact system in plasma.
Anne Cathrine Godtfredsen +10 more
doaj +1 more source