Results 41 to 50 of about 14,789,955 (251)

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.

Blood, 2020
The contact system is composed of Factor XII (FXII), prekallikrein (PK) and co-factor kininogen (HK). The globular C1q receptor (gC1qR) has been shown to interact with FXII and HK. We reveal the FXII fibronectin type II domain (FnII) binds gC1qR in a Zn2+
B. G. Kaira, Alexandre Slater, K. McCrae, I. Dreveny, Um-May Sumya, N. Mutch, M. Searle, J. Emsley   +7 more
semanticscholar   +1 more source

Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa

Journal of Neuroinflammation, 2017
Background Traumatic brain injury (TBI) is a devastating neurological condition and a frequent cause of permanent disability. Posttraumatic inflammation and brain edema formation, two pathological key events contributing to secondary brain injury, are ...
Sarah Hopp, Marc W. Nolte, Christian Stetter, Christoph Kleinschnitz, Anna-Leena Sirén, Christiane Albert-Weissenberger   +5 more
doaj   +1 more source

Profilaxis con inhibidor de C1 normal en angioedema hereditario

Revista Alergia México, 2021
Introducción: El angioedema hereditario es una enfermedad genética poco frecuente; manifestado principalmente con edema cutáneo o mucoso. Pequeños traumas pueden producir eventos potencialmente fatales.
Dina Glocer, Ariela González, Mercedes Elizabeth Parrales-Villacreses, Pablo Martínez, Claudio Alberto Salvador Parisi   +4 more
doaj   +1 more source

ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIES

Российский кардиологический журнал, 2018
Objective. This study was devoted to examinationof some factors of blood coagulation (factor II, factor VII, factor XII, antithrombin III) in order to find their associations with biomarkers of endothelial dysfunction (endothelin 1 ...
Yu. I. Ragino, E. V. Striukova, I. S. Murashov, Ya. V. Polonskaya, A. M. Volkov, E. V. Kashtanova, A. V. Kurguzov, A. M. Chernjavskii   +7 more
doaj   +1 more source

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain.

Blood, 2019
The plasma proteins factor XII (FXII) and prekallikrein (PK) undergo reciprocal activation to the proteases FXIIa and kallikrein by a process that is enhanced by surfaces (contact activation) and regulated by the serpin C1 inhibitor.
Ivan Ivanov, A. Matafonov, Mao-Fu Sun, B. Mohammed, Qiu-Fang Cheng, S. Dickeson, S. Kundu, Ingrid M. Verhamme, A. Gruber, K. McCrae, D. Gailani   +10 more
semanticscholar   +1 more source

Comparison of factor XII levels in gestational diabetes, fetal macrosomia, and healthy pregnancies

BMC Pregnancy and Childbirth, 2020
Background If not detected and treated, gestational diabetes mellitus (GDM) can cause serious pregnancy complications such as macrosomia, preeclampsia, and fetal/neonatal mortality.
Esra Ozbasli, Ozguc Takmaz, Emine Karabuk, Mete Gungor   +3 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Association of some hemostasis and endothelial dysfunction factors with probability of presence of vulnerable atherosclerotic plaques in patients with coronary atherosclerosis

BMC Research Notes, 2019
Objective The study was dedicated to investigation of some hemostasis and endothelial dysfunction factors association with probability of presence of vulnerable atherosclerotic plaques in coronary arteries in men with atherosclerosis.
Yu. I. Ragino, E. V. Striukova, I. S. Murashov, Ya. V. Polonskaya, A. M. Volkov, A. V. Kurguzov, A. M. Chernjavskii, E. V. Kashtanova   +7 more
doaj   +1 more source

Skeletal prognathism with factor XII deficiency causing complications in perioperative management: A case report

Advances in Oral and Maxillofacial Surgery, 2021
A 21-year-old man with mandibular prognathism was referred to Tokyo Medical University Hospital. The patient was diagnosed as having skeletal prognathism.
Hayato Hamada, Yoko Kawase-Koga, On Hasegawa, Masato Watanabe, Daichi Chikazu   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source