Results 41 to 50 of about 15,476,282 (336)

Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

Research and Practice in Thrombosis and Haemostasis, 2020
The contact factor XII (FXII) activates upon contact with a variety of charged surfaces. Activated FXII (FXIIa) activates factor XI, which activates factor IX, resulting in thrombin generation, platelet activation, and fibrin formation.
M. Wallisch, C. Lorentz, H. Lakshmanan, Jennifer J. Johnson, Marschelle R. Carris, C. Puy, D. Gailani, M. Hinds, O. McCarty, A. Gruber, E. Tucker   +10 more
semanticscholar   +1 more source

Evaluation of Factor XII Activity in Women with Recurrent Miscarriages

Bezmiâlem Science, 2018
Objective:Our aim is to evaluate factor XII activity in women with recurrent miscarriages by active partial thromboplastin time (aPTT) measurement.Methods:This study was conducted in 145 patients admitted to our clinic with recurrent miscarriages between
Nilay KARACA, Lebriz Hale AKTÜN
doaj   +1 more source

Cold-induced urticarial autoinflammatory syndrome related to factor XII activation

Nature Communications, 2020
Hereditary autoinflammatory diseases are caused by gene mutations of the innate immune pathway, e.g. nucleotide receptor protein 3 (NLRP3). Here, we report a four-generation family with cold-induced urticarial rash, arthralgia, chills, headache and ...
J. Scheffel, Niklas A. Mahnke, Z. Hofman, S. Maat, Jim Wu, H. Bonnekoh, R. Pengelly, S. Ennis, J. Holloway, Marieluise Kirchner, Phillip Mertins, M. Church, M. Maurer, C. Maas, K. Krause   +14 more
semanticscholar   +1 more source

Inflammation and Coagulation are Two Interconnected Pathophysiological Pathways in Atrial Fibrillation Pathogenesis

Journal of Inflammation Research, 2023
Lusine Hazarapetyan,1,2 Parounak H Zelveian,2 Svetlana Grigoryan1,2 1Department of Cardiology, Yerevan State Medical University Named After M. Heratsi, Yerevan, Armenia; 2Scientific Research Institute of Cardiology Named After L Hovhannisyan, Yerevan ...
Hazarapetyan L, Zelveian PH, Grigoryan S
doaj  

Acquired factor XII deficiency in a woman with recurrent pregnancy loss: working on a differential diagnosis in a single case

Journal of Translational Medicine, 2005
Background Antiphospholipid syndrome (APS) has been often associated to RPL since 1980 and some reports in the Literature rarely described antibodies to factor XII in patients with APS.
Di Micco Pierpaolo, De Placido Giuseppe, Ranieri Antonio, Mollo Antonio, Strina Ida, D'Uva Maristella   +5 more
doaj   +1 more source

The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders—A Systematic Review

Frontiers in Immunology, 2018
Background The interaction of coagulation factors has been shown to go beyond their traditional roles in hemostasis and to affect the development of inflammatory diseases.
K. Göbel, Susann Eichler, H. Wiendl, T. Chavakis, C. Kleinschnitz, S. Meuth   +5 more
semanticscholar   +1 more source

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.

Blood, 2020
The contact system is composed of Factor XII (FXII), prekallikrein (PK) and co-factor kininogen (HK). The globular C1q receptor (gC1qR) has been shown to interact with FXII and HK. We reveal the FXII fibronectin type II domain (FnII) binds gC1qR in a Zn2+
B. G. Kaira, Alexandre Slater, K. McCrae, I. Dreveny, Um-May Sumya, N. Mutch, M. Searle, J. Emsley   +7 more
semanticscholar   +1 more source

Anti-Factor XII Autoantibodies in Patients with Recurrent Pregnancy Loss Recognize the Second Epidermal Growth Factor–Like Domain

TH Open, 2019
Summary Background Factor XII (FXII) deficiency and autoantibodies that bind to FXII (anti-FXII) have been described in patients with adverse pregnancy outcomes, including recurrent pregnancy loss.
Yoshihiro Sato, Toshitaka Sugi, Rie Sakai   +2 more
doaj   +1 more source

Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice. [PDF]

PLoS ONE, 2016
Sepsis, a systemic inflammatory response to infection, is often accompanied by abnormalities of blood coagulation. Prior work with a mouse model of sepsis induced by cecal ligation and puncture (CLP) suggested that the protease factor XIa contributed to ...
Charles E Bane, Ivan Ivanov, Anton Matafonov, Kelli L Boyd, Qiufang Cheng, Edward R Sherwood, Erik I Tucker, Stephen T Smiley, Owen J T McCarty, Andras Gruber, David Gailani   +10 more
doaj   +1 more source

The prevalence of heterozygous F12 mutations in Chinese population and its relevance to incidents of thrombosis

BMC Medical Genetics, 2018
Background The contribution of moderate coagulation factor XII (FXII) deficiency to development of thromboembolism is still undetermined. We have tried to show the relevance of FXII deficiency to incidences of venous thrombosis by exploring the ...
Xi Wu, Qiulan Ding, Xuefeng Wang, Jing Dai, Wenman Wu   +4 more
doaj   +1 more source