Results 11 to 20 of about 14,789,955 (251)

Homozygous missense variant F12 (Gly506Asp) associated with severe factor XII deficiency: a case report [PDF]

Journal of Medical Case Reports, 2023
Background Factor XII deficiency can be related to either homozygous or compound heterozygous pathogenic variants in the F12 gene. The disease is commonly known as Hageman trait and is inherited in both autosomal recessive or dominant patterns ...
Mansour Aljabry, Aljoud Algazlan, Nouf Alsubaie, Shatha Bin Dher, Hassan Semar Aljabri, Ghazi S. Alotaibi   +5 more
doaj   +2 more sources

Hereditary factor XII deficiency in an adult patient: A case report [PDF]

SAGE Open Medical Case Reports, 2022
Factor XII deficiency is a rare autosomal recessive health condition usually discovered incidentally during routine coagulation screening before surgery after investigating a prolongation of the activated partial thromboplastin time.
Rehab Y Al-Ansari, Fatimah Al-Yami, Ghayah Almulhim, Alexander Woodman   +3 more
doaj   +2 more sources

Factor XII (Hageman Factor) Deficiency: a rare harbinger of life threatening complications

The Pan African Medical Journal, 2019
Hageman factor (factor XII) has a key role in activation of intrinsic coagulation system gauged by activated partial thromboplastin time (aPPT)).
Liaqat Ali Chaudhry, Wael Yasin Mohamed El-Sadek, Ghazala Aslam Chaudhry, Feddha Eid Al-Atawi   +3 more
doaj   +2 more sources

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

Nature Communications, 2016
Factor XII initiates the intrinsic blood coagulation cascade and the kinin system. Here the authors show that Factor XII is elevated in the blood of multiple sclerosis patients, activates dendritic cells via CD87 and cAMP, and its blockade inhibits ...
Kerstin Göbel, Susann Pankratz, Chloi-Magdalini Asaridou, Alexander M. Herrmann, Stefan Bittner, Monika Merker, Tobias Ruck, Sarah Glumm, Friederike Langhauser, Peter Kraft, Thorsten F. Krug, Johanna Breuer, Martin Herold, Catharina C. Gross, Denise Beckmann, Adelheid Korb-Pap, Michael K. Schuhmann, Stefanie Kuerten, Ioannis Mitroulis, Clemens Ruppert, Marc W. Nolte, Con Panousis, Luisa Klotz, Beate Kehrel, Thomas Korn, Harald F. Langer, Thomas Pap, Bernhard Nieswandt, Heinz Wiendl, Triantafyllos Chavakis, Christoph Kleinschnitz, Sven G. Meuth   +31 more
doaj   +2 more sources

Congenital hemophilia A with low activity of factor XII: a case report and literature review [PDF]

Italian Journal of Pediatrics, 2021
Background Congenital hemophilia A is a recessive inherited hemorrhagic disorder. According to the activity of functional coagulation factors, the severity of hemophilia A is divided into three levels: mild, moderate and severe.
Baoyu Lei, Chuang Liang, Haiyan Feng
doaj   +2 more sources

A brief comparison of human factor XII-Ala188 and factor XII-Pro188 [PDF]

Research and Practice in Thrombosis and Haemostasis
Aleksandr Shamanaev, David Gailani
doaj   +2 more sources

Phenotypic and genetic analyses of four cases of coagulation factor XII deficiency

Hematology, 2022
Objectives To identify the clinical phenotypic and molecular pathogeneses of four cases of coagulation factor XII deficiency and to deepen the cognition of this disease.Methods Coagulation tests were performed through one stage of coagulation on a STAGO ...
Shanshan Li, Kuangyi Shu, Fanfan Li, Xiao Yang, Wei Yang, Manli Ye, Xiaoou Wang, Minghua Jiang   +7 more
doaj   +1 more source

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Nature Communications, 2021
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay.
Marco Heestermans, C. Naudin, R. Mailer, S. Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, C. Deppermann, G. Pula, P. Kuta, M. Friese, M. Gelderblom, A. Sickmann, R. Preston, J. Nofer, S. Rose-John, L. Butler, O. Salomon, E. Stavrou, T. Renné   +19 more
semanticscholar   +1 more source

An update on factor XII-driven vascular inflammation.

Biochimica et biophysica acta. Molecular cell research, 2021
The plasma protein factor XII (FXII) is the liver-derived zymogen of the serine protease FXIIa that initiates an array of proteolytic cascades. Zymogen activation, enzymatic FXIIa activity and functions are regulated by interactions with cell receptors ...
R. Mailer, C. Rangaswamy, S. Konrath, J. Emsley, T. Renné   +4 more
semanticscholar   +1 more source

The effect of titanium dioxide particles of different shapes and sizes on the factor XII protein (intrinsic coagulation pathway)

Medicine Science, 2021
Titanium dioxide (TiO2) nanoparticles are widely used in food, cosmetics, biomedical implants, and pharmaceutical fields. Their effect on blood coagulation in human plasma and blood have been demonstrated.
Evren Kilinc
doaj   +1 more source