Results 11 to 20 of about 15,476,282 (336)
Cardiopulmonary bypass in a pediatric patient with factor XII deficiency [PDF]
The Journal of ExtraCorporeal TechnologyThe safe use of cardiopulmonary bypass (CPB) relies upon the ability to administer, monitor, and reverse anticoagulation. Although rare, the factor XII deficient patient creates a challenge for the perfusionist due to resultant complications in ...
Fenske Julie M. +2 more
doaj +2 more sources
Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis [PDF]
Nature CommunicationsCoagulation factor XII has been identified as a potential drug target that could prevent thrombosis without increasing the risk of bleeding. However, human data to support the development of factor XII-directed therapeutics are lacking.
Amelia K. Haj +20 more
doaj +2 more sources
Hereditary factor XII deficiency in an adult patient: A case report [PDF]
SAGE Open Medical Case Reports, 2022 Factor XII deficiency is a rare autosomal recessive health condition usually discovered incidentally during routine coagulation screening before surgery after investigating a prolongation of the activated partial thromboplastin time.
Rehab Y Al-Ansari +3 more
doaj +2 more sources
Factor XII (Hageman Factor) Deficiency: a rare harbinger of life threatening complications
The Pan African Medical Journal, 2019 Hageman factor (factor XII) has a key role in activation of intrinsic coagulation system gauged by activated partial thromboplastin time (aPPT)).
Liaqat Ali Chaudhry +3 more
doaj +2 more sources
Nature Communications, 2016 Factor XII initiates the intrinsic blood coagulation cascade and the kinin system. Here the authors show that Factor XII is elevated in the blood of multiple sclerosis patients, activates dendritic cells via CD87 and cAMP, and its blockade inhibits ...
Kerstin Göbel +31 more
doaj +2 more sources
Congenital hemophilia A with low activity of factor XII: a case report and literature review [PDF]
Italian Journal of Pediatrics, 2021 Background Congenital hemophilia A is a recessive inherited hemorrhagic disorder. According to the activity of functional coagulation factors, the severity of hemophilia A is divided into three levels: mild, moderate and severe.
Baoyu Lei, Chuang Liang, Haiyan Feng
doaj +2 more sources
An unanticipated prolonged baseline ACT during cardiac surgery due to factor XII deficiency [PDF]
Annals of Cardiac Anaesthesia, 2022 Factor XII (FXII) deficiency is a congenital disorder inherited as an autosomal recessive condition. In his heterozygous form, it is relatively common in the general population.
Heleen J.C L. Apostel +3 more
doaj +2 more sources
Factor XII: form determines function
Journal of Thrombosis and Haemostasis, 2016 Factor XII is a mysterious plasma protein without a clear physiologic function. It was identified as a clotting factor, but has no clear role in hemostasis. However, FXII also contributes to the production of bradykinin, a short-lived inflammatory peptide.
S, de Maat, C, Maas
openaire +3 more sources
Phenotypic and genetic analyses of four cases of coagulation factor XII deficiency
Hematology, 2022 Objectives To identify the clinical phenotypic and molecular pathogeneses of four cases of coagulation factor XII deficiency and to deepen the cognition of this disease.Methods Coagulation tests were performed through one stage of coagulation on a STAGO ...
Shanshan Li +7 more
doaj +1 more source
An update on factor XII-driven vascular inflammation.
Biochimica et biophysica acta. Molecular cell research, 2021 The plasma protein factor XII (FXII) is the liver-derived zymogen of the serine protease FXIIa that initiates an array of proteolytic cascades. Zymogen activation, enzymatic FXIIa activity and functions are regulated by interactions with cell receptors ...
R. Mailer +4 more
semanticscholar +1 more source