Results 11 to 20 of about 34,813 (259)
Single-chain factor XII: a new form of activated factor XII [PDF]
Current Opinion in Hematology, 2017 Purpose of review Exposure of blood to foreign surfaces induces reciprocal conversion of the plasma proteins factor XII (fXII) and plasma prekallikrein (PPK) to the proteases α-fXIIa and α-kallikrein. This process, called contact activation, has a range of effects on host defence mechanisms, including promoting coagulation. The
Ivan, Ivanov +2 more
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Activation of factor XII by dextran sulfate: the basis for an assay of factor XII [PDF]
Blood, 1983 A system was developed for studying the activation of factor XII (Hageman factor) in the presence of dextran sulfate (DS). Salient features of the system included low ionic strength (0.08), low concentration of factor XII (approximately 1/10,000 that in normal plasma), and an excess of exogenous prekallikrein (PK).
D L, Tankersley +2 more
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Medicine Science, 2021 Titanium dioxide (TiO2) nanoparticles are widely used in food, cosmetics, biomedical implants, and pharmaceutical fields. Their effect on blood coagulation in human plasma and blood have been demonstrated.
Evren Kilinc
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Journal of Neuroanaesthesiology and Critical Care, 2020 Factor XII deficiency is a rare disorder that can complicate the perioperative management of a patient. Factor XII plays an important role in the activation of intrinsic pathway of coagulation; the deficiency, therefore, results in prolongation of ...
Mouleeswaran Sundaram +2 more
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Frontiers in Medicine, 2018 Until recently, the role of factor XII (FXII) in hemostasis was not considered to be important since patients with FXII deficiency do not present with bleeding.
Helen V. Wilmot +3 more
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Factor XII – A Limitation for Divers? [PDF]
Polish Hyperbaric Research, 2015 Abstract The lack of evidence for the tissue-factor dependent activation of the coagulation system and the release of thrombin on one hand, and a decreased concentration of factor XII after short term air, saturated air and heliox exposures, as well as an increased concentration of the plasmin-antiplasmin complex (PAP) after short dives
Olszański, Romuald +3 more
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In vivo roles of factor XII [PDF]
Blood, 2012 AbstractCoagulation factor XII (FXII, Hageman factor, EC = 3.4.21.38) is the zymogen of the serine protease, factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced by “contact” to charged surfaces. FXIIa is of crucial importance for fibrin formation in vitro, but deficiency in the protease is not associated with excessive ...
Thomas, Renné +4 more
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Activity of factor XII‐Locarno [PDF]
Research and Practice in Thrombosis and Haemostasis, 2018 Factor XII (FXII) Locarno is a natural variant with proline replacing Arg353 at the activation cleavage site, preventing conversion to the fully active protease factor XIIa (FXIIa). Recently, we showed that FXII restricted to a single chain form (sc-FXII) by replacing Arg353 with alanine expresses proteolytic activity that is enhanced by cofactors such
Mohammed, Bassem M. +4 more
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The new era of anticoagulation: factor XI and XII inhibitors
Bleeding, Thrombosis and Vascular Biology, 2023 The two last decades have witnessed a revolution in the field of anticoagulation, mainly due to the advent of direct anticoagulant with targeted action against single coagulation proteins. However, the residual risk of cardio- and cerebrovascular events,
Domenico Prisco +3 more
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Science-Business eXchange, 2014 Researchers have found that inhibiting either factor XII or factor XI can provide thromboprotection without increasing the risk of bleeding. Both targets could eliminate the main drawback of existing anticoagulants.
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