Results 31 to 40 of about 16,601 (180)
Mutant plasminogen in hereditary angioedema is bypassing FXII/kallikrein to generate bradykinin
Frontiers in Physiology, 2023 Hereditary angioedema (HAE) is characterized by recurrent localized edema in various organs, which can be potentially fatal. There are different types of hereditary angioedema, which include genetic deficiency of C1 inhibitor (C1-INH) and hereditary ...
Stefan Hintze +12 more
doaj +1 more source
Stem Cells International, 2019 Background/Objectives. Carbonic anhydrase 1 (CA1)/kininogen and selenoprotein W (SelW)/14-3-3η signal transduction orchestrate oxidative stress, which can also be regulated by nitric oxide (NO).
Wan-cheng Yu +6 more
doaj +1 more source
Scientific Reports, 2021 Insulin has metabolic and vascular effects in the human body. What mechanisms that orchestrate the effects in the microcirculation, and how the responds differ in different tissues, is however not fully understood.
Alexandra Högstedt +3 more
doaj +1 more source
Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification
Angewandte Chemie International Edition, EarlyView.Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang +12 more
wiley +1 more source
Plasma Prekallikrein: Its Role in Hereditary Angioedema and Health and Disease
Frontiers in Medicine, 2018 Plasma prekallikrein (PK) has a critical role in acute attacks of hereditary angioedema (HAE). Unlike C1 inhibitor, its levels fall during HAE attacks with resultant cleaved high-molecular-weight kininogen.
Alvin H. Schmaier
doaj +1 more source
International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 206-214, April 2025.Abstract Objective Antiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.
Titi Yang +11 more
wiley +1 more source
Kininogen binding to the surfaces of macrophages
International Immunopharmacology, 2008 Kinin generation may be initiated on the cell surfaces via a primary kininogen docking which has been characterized for endothelial cells, platelets, neutrophils, astrocytes and smooth muscle cells. In this work we describe the adsorption of biotin-labeled human kininogens by murine RAW 264.7 macrophages and human U-937 monocytes/macrophages. Both cell
Barbasz, Anna +3 more
openaire +3 more sources
Suppressed Angiogenesis in Kininogen-Deficiencies [PDF]
Laboratory Investigation, 2002 We investigated whether the kinin-generating system enhanced angiogenesis in chronic and proliferative granuloma and in tumor-surrounding stroma. In rat sponge implants, angiogenesis was gradually developed in normal Brown Norway Kitasato rats (BN-Ki).
Izumi, Hayashi +9 more
openaire +2 more sources
Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
wiley +1 more source
The kallikrein–kinin pathway as a mechanism for auto-control of brown adipose tissue activity
Nature Communications, 2020 Brown adipose tissue, known produce heat by metabolizing fat, is also secretes molecules capable of communicating with other organs. Here the authors show that brown adipose tissue secretes kininogen, a component of heat system regulation, that provides ...
Marion Peyrou +10 more
doaj +1 more source