The complex role of kininogens in hereditary angioedema [PDF]
Frontiers in Allergy, 2022 Human high molecular weight kininogen (HK) is the substrate from which bradykinin is released as a result of activation of the plasma “contact” system, a cascade that includes the intrinsic coagulation pathway, and a fibrinolytic pathway leading to the ...
Allen P. Kaplan +2 more
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Mechanisms involved in hereditary angioedema with normal C1-inhibitor activity [PDF]
Frontiers in Physiology, 2023 Patients with the inherited disorder hereditary angioedema (HAE) suffer from episodes of soft tissue swelling due to excessive bradykinin production.
Aleksandr Shamanaev +9 more
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Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond [PDF]
Frontiers in Physiology, 2023 Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight ...
Guacyara Motta +2 more
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Hexapod Assassins’ Potion: Venom Composition and Bioactivity from the Eurasian Assassin Bug Rhynocoris iracundus [PDF]
Biomedicines, 2021 Assassin bug venoms are potent and exert diverse biological functions, making them potential biomedical goldmines. Besides feeding functions on arthropods, assassin bugs also use their venom for defense purposes causing localized and systemic reactions ...
Nicolai Rügen +9 more
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Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis [PDF]
EBioMedicine, 2020 Background: High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis.
Juliane Köhler +10 more
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Drugs of the Kallikrein–Kinin System: An Overview
Drugs and Drug Candidates, 2023 The kallikrein–kinin system consists of the two kininogen substrates present in the blood plasma, and two serine proteases: the plasma and tissue kallikreins.
François Marceau
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Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies
Cells, 2021 The kallikrein-kinin system (KKS) contributes to retinal inflammation and neovascularization, notably in diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD).
Rahmeh Othman +4 more
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Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID-19
Mediators of Inflammation, 2022 The COVID-19 pandemic is rapidly spreading, and health care systems are being overwhelmed with the huge number of cases, with a good number of cases requiring intensive care.
Aisha Tabassum +8 more
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Fishes, 2022 Cysteine proteinase inhibitors (CPIs) protect tissues and organs against cysteine proteinases in animal blood and have attracted much attention for use in food processing and medical sciences for humans and animals.
Seong Hee Mun, Joon Yeong Kwon
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Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis. [PDF]
PLoS ONE, 2011 Cysteine cathepsins have emerged as new players in inflammatory lung disorders. Their activities are dramatically increased in the sputum of cystic fibrosis (CF) patients, suggesting that they are involved in the pathophysiology of CF.
Clément Naudin +9 more
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