Results 11 to 20 of about 1,270 (154)
Immunological characterization of rat kininogens with monoclonal antibodies to T‐kininogen. [PDF]
European Journal of Biochemistry, 1992 A panel of 16 monoclonal antibodies (mAb) were produced against rat T‐kininogen to characterize this family of proteins. These mAbs bound 125I‐T‐kininogen by radioimmunoassay as well as reacting strongly with immobilized T‐kininogen in an enzyme‐linked immunosorbent assay (ELISA).
S, Lesage +7 more
openaire +2 more sources
Role of Kinins in Hypertension and Heart Failure
Pharmaceuticals, 2020 The kallikrein–kinin system (KKS) is proposed to act as a counter regulatory system against the vasopressor hormonal systems such as the renin-angiotensin system (RAS), aldosterone, and catecholamines.
Suhail Hamid +3 more
doaj +1 more source
The Kallikrein-Kinin System: Current and Future Pharmacological Targets
Journal of Pharmacological Sciences, 2005 The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and
Marie Eve Moreau +5 more
doaj +1 more source
In Vitro Modeling of Bradykinin-Mediated Angioedema States
Pharmaceuticals, 2020 Kinins (peptides related to bradykinin, BK) are formed from circulating substrates, the kininogens, by the action of two proteases, the kallikreins.
François Marceau +4 more
doaj +1 more source
Comparative analysis of cystatin superfamily in platyhelminths. [PDF]
PLoS ONE, 2015 The cystatin superfamily is comprised of cysteine proteinase inhibitors and encompasses at least 3 subfamilies: stefins, cystatins and kininogens. In this study, the platyhelminth cystatin superfamily was identified and grouped into stefin and cystatin ...
Aijiang Guo
doaj +1 more source
Intensive Care Medicine Experimental, 2019 Background Kinins are short peptides with a wide range of proinflammatory properties that are generated from kininogens in the so-called kallikrein-kinin system.
Chao Ding +3 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2023 Objective Patients with rheumatoid arthritis (RA) have shown increased levels of neutrophils generating kallikrein-kinin peptides in blood which are potent mediators of inflammation.
Dino B. A. Tan +9 more
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A Cross-Sectional Study of KLKB1 and PRCP Polymorphisms in Patients with Cardiovascular Disease
Frontiers in Medicine, 2016 Plasma kallikrein formed from prekallikrein (PK) produces bradykinin from kininogens and activates factor XII. Plasma PK is activated by factors XIIa, XIIa or prolylcarboxypeptidase (PRCP).
Haley R. Gittleman +6 more
doaj +1 more source
Isolation and characterization of ornitho‐kininogen [PDF]
European Journal of Biochemistry, 1987 Ornitho‐kininogen was purified from chicken blood plasma by a two‐stage method using chromatography on columns of S‐alkylated papain‐Cellulofine and DEAE‐5PW. The yield was 1.7 mg from 44 ml plasma. The isolated preparation gave a single band on sodium dodecyl sulfate/polyacrylamide gel electrophoresis (SDS‐PAGE) with or without 2‐mercaptoethanol and ...
M, Kimura +5 more
openaire +2 more sources
Molecular biology of the kallikrein-kinin system: from structure to function
Brazilian Journal of Medical and Biological Research, 1998 The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a ...
J.B. Pesquero, M. Bader
doaj +1 more source