Results 21 to 30 of about 1,270 (154)

Kininogens Are Antithrombotic Proteins In Vivo [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 1999
Abstract —Kininogens have recently been shown to possess antiadhesive, anticoagulant, and profibrinolytic properties and can inhibit platelet activation at low thrombin concentrations. To test whether kininogens have antithrombotic properties in vivo, we devised a model of limited arterial injury confined to removal of the ...
R W, Colman, J V, White, S, Scovell, A, Stadnicki, R B, Sartor   +4 more
openaire   +2 more sources

Evidence for the presence of a kininogen-like species in a case of total deficiency of low and high molecular weight kininogens

Brazilian Journal of Medical and Biological Research, 1998
Low and high molecular weight kininogens (LK and HK), containing 409 and 626 amino acids with masses of ~65 and 120 kDa after glycosylation, respectively, are coded by a single gene mapped to the human chromosome 3 by alternative splicing of the ...
D. Veloso
doaj   +1 more source

Peptide IC-20, encoded by skin kininogen-1 of the European yellow-bellied toad, Bombina variegata, antagonizes bradykinin-induced arterial smooth muscle relaxation

Journal of Pharmacy and Bioallied Sciences, 2011
Objectives: The objectives were to determine if the skin secretion of the European yellow-bellied toad (Bombina variegata), in common with other related species, contains a bradykinin inhibitor peptide and to isolate and structurally characterize this ...
Mu Yang, Mei Zhou, Bing Bai, Chengbang Ma, Le Wei, Lei Wang, Tianbao Chen, Chris Shaw   +7 more
doaj   +1 more source

Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors

Parasites & Vectors, 2012
Background Kinins liberated from plasma–borne kininogens, are potent innate stimulatory signals. We evaluated whether resistance to infection by Leishmania (L.) chagasi depends on activation of G-protein coupled bradykinin B2 receptors (B2R).
Nico Dirlei, Feijó Daniel, Maran Naiara, Morrot Alexandre, Scharfstein Julio, Palatnik Marcos, Palatnik-de-Sousa Clarisa   +6 more
doaj   +1 more source

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

Angewandte Chemie International Edition, EarlyView.
Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang, Jingqu Chen, Siying Chen, Binsha Peng, Zhifeng Zhou, Ling Zhang, Rui Xie, Xiaojie Ju, Wei Wang, Dawei Pan, Liangyin Chu, Frank Caruso, Zhuang Liu   +12 more
wiley   +1 more source

Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 206-214, April 2025.
Abstract Objective Antiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.
Titi Yang, Emi Okada, Maho Todoroki, Siyu Liu, Rukmali Athurupana, Kumie Kataoka, Chiaki Kashino, Takashi Mitsui, Toru Hasegawa, Yasuhiko Kamada, Hisashi Masuyama, Mikiya Nakatsuka   +11 more
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Kininogen binding to the surfaces of macrophages

International Immunopharmacology, 2008
Kinin generation may be initiated on the cell surfaces via a primary kininogen docking which has been characterized for endothelial cells, platelets, neutrophils, astrocytes and smooth muscle cells. In this work we describe the adsorption of biotin-labeled human kininogens by murine RAW 264.7 macrophages and human U-937 monocytes/macrophages. Both cell
Barbasz, Anna, Guevara Lora, Ibeth, Rąpała-Kozik, Maria, Kozik, Andrzej   +3 more
openaire   +3 more sources

Suppressed Angiogenesis in Kininogen-Deficiencies [PDF]

Laboratory Investigation, 2002
We investigated whether the kinin-generating system enhanced angiogenesis in chronic and proliferative granuloma and in tumor-surrounding stroma. In rat sponge implants, angiogenesis was gradually developed in normal Brown Norway Kitasato rats (BN-Ki).
Izumi, Hayashi, Hideki, Amano, Satoko, Yoshida, Kazuhisa, Kamata, Mariko, Kamata, Madoka, Inukai, Tomoe, Fujita, Yuji, Kumagai, Sen-ichi, Furudate, Masataka, Majima   +9 more
openaire   +2 more sources

Contact Activation Is Alleviated by Testosterone Replacement Therapy in Klinefelter Syndrome: Evidence of Hormonal and Metabolic Modulation

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome is associated with a markedly increased risk of venous thrombosis. While hypogonadism and metabolic dysfunction are known contributors, the role of the contact activation system in Klinefelter syndrome remains unexplored.
Simon Chang, Claus H. Gravholt, Anne Skakkebæk, Anna‐Marie Bloch Münster, Yaseelan Palarasah   +4 more
wiley   +1 more source