Results 1 to 10 of about 5,150 (108)

Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19 [PDF]

EBioMedicine, 2022
Summary: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system.
Caroline P. Martens, Pierre Van Mol, Joost Wauters, Els Wauters, Tanja Gangnus, Bernard Noppen, Hanne Callewaert, Jean H.M. Feyen, Laurens Liesenborghs, Elisabeth Heylen, Sander Jansen, Leydi Carolina Velásquez Pereira, Sirima Kraisin, Ipek Guler, Matthias M. Engelen, Anna Ockerman, Anke Van Herck, Robin Vos, Christophe Vandenbriele, Philippe Meersseman, Greet Hermans, Alexander Wilmer, Kimberly Martinod, Bjoern B. Burckhardt, Marc Vanhove, Marc Jacquemin, Peter Verhamme, Johan Neyts, Thomas Vanassche   +28 more
doaj   +2 more sources

Recent advances in the discovery and development of drugs targeting the kallikrein-kinin system [PDF]

Journal of Translational Medicine
Background The kallikrein-kinin system is a key regulatory cascade involved in blood pressure maintenance, hemostasis, inflammation and renal function. Currently, approved drugs remain limited to the rare disease hereditary angioedema.
Petra Wisniewski, Tanja Gangnus, Bjoern B. Burckhardt   +2 more
doaj   +2 more sources

Impaired Kallikrein-Kinin System in COVID-19 Patients' Severity [PDF]

Frontiers in Immunology, 2022
COVID-19 has emerged as a devastating disease in the last 2 years. Many authors appointed to the importance of kallikrein-kinin system (KKS) in COVID-19 pathophysiology as it is involved in inflammation, vascular homeostasis, and coagulation.
Enrique Alfaro, Elena Díaz-García, Elena Díaz-García, Sara García-Tovar, Ester Zamarrón, Ester Zamarrón, Alberto Mangas, Raúl Galera, Raúl Galera, Kapil Nanwani-Nanwani, Rebeca Pérez-de-Diego, Rebeca Pérez-de-Diego, Eduardo López-Collazo, Francisco García-Río, Francisco García-Río, Francisco García-Río, Carolina Cubillos-Zapata, Carolina Cubillos-Zapata   +17 more
doaj   +2 more sources

Interrelation among exercise training, cardiac hypertrophy, and tissue kallikrein-kinin system in athlete and non-athlete women [PDF]

Journal of Cardiovascular and Thoracic Research, 2022
Introduction: The tissue kallikrein-kinin system is an endogenous homeostatic pathway, which its stimulation is associated with cardioprotection. The present study aimed to determine the effect of exercise training on plasma tissue kallikrein (TK) and ...
Behnam Heidari, Mohammad Reza Zolfaghari, Kamal Khademvatani, Amir Fattahi, Reza Zarezadeh   +4 more
doaj   +2 more sources

Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans [PDF]

Frontiers in Physiology, 2017
Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin. In the proximity of its target cells, high molecular weight kininogen (H-kininogen) is the substrate of plasma kallikrein, which releases bradykinin from H ...
Guacyara Motta, Ivarne L. S. Tersariol
doaj   +2 more sources

Role of the kallikrein–kinin system in traumatic brain injury [PDF]

Frontiers in Cellular Neuroscience, 2014
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite improvements in acute intensive care, there are currently no specific therapies to ameliorate the effects of TBI. Successful therapeutic strategies for TBI should
Christiane eAlbert-Weissenberger, Stine eMencl, Sarah eHopp, Christoph eKleinschnitz, Anna-Leena eSirén   +4 more
doaj   +2 more sources

Garadacimab for the long-term prophylaxis of hereditary angioedema. [PDF]

J Dtsch Dermatol Ges
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Aygören-Pürsün E, Treudler R, Staubach P, Saguer IM, Linhoff T, Magerl M.   +5 more
europepmc   +2 more sources

Garadacimab zur Langzeitprophylaxe bei hereditärem Angioödem [PDF]

J Dtsch Dermatol Ges
Zusammenfassung Das hereditäre Angioödem (Hereditary angioedema, HAE), eine seltene und belastende Erkrankung, die durch rezidivierende und spontane Gewebeschwellungsattacken gekennzeichnet ist, weist einen hohen ungedeckten therapeutischen Bedarf auf, da Patienten unter aktuellen prophylaktischen Behandlungen eine unzureichende Krankheitskontrolle ...
Aygören‐Pürsün E, Treudler R, Staubach P, Saguer I, Linhoff T, Magerl M.   +5 more
europepmc   +2 more sources

Editorial: Kallikrein-kinin system: insights into a multifunctional system [PDF]

Frontiers in Physiology, 2023
Guacyara Motta, Luiz Juliano, Zia Shariat-Madar   +2 more
doaj   +2 more sources

Ex vivo bradykinin as a functional biomarker for angioedema with normal C1-inhibitor [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Bradykinin-mediated angioedema (AE-BK) remains diagnostically challenging particularly in patients with normal C1-inhibitor, where diagnosis primarily relies on clinical criteria. Routine laboratory tests can identify complement deficiency in
Jinguo Chen, MD, J. Joanna Yu, MD, PhD, Joseph Chiao, MD, Yunkou Wu, PhD, Mark D. Scarupa, MD, Lili Wan, PhD, H. Henry Li, MD, PhD   +6 more
doaj   +2 more sources