Role of the kallikrein–kinin system in traumatic brain injury [PDF]
Frontiers in Cellular Neuroscience, 2014 Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite improvements in acute intensive care, there are currently no specific therapies to ameliorate the effects of TBI. Successful therapeutic strategies for TBI should
Christiane eAlbert-Weissenberger +4 more
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Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19 [PDF]
EBioMedicine, 2022 Summary: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system.
Caroline P. Martens +28 more
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Recent advances in the discovery and development of drugs targeting the kallikrein-kinin system [PDF]
Journal of Translational MedicineBackground The kallikrein-kinin system is a key regulatory cascade involved in blood pressure maintenance, hemostasis, inflammation and renal function. Currently, approved drugs remain limited to the rare disease hereditary angioedema.
Petra Wisniewski +2 more
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Impaired Kallikrein-Kinin System in COVID-19 Patients' Severity [PDF]
Frontiers in Immunology, 2022 COVID-19 has emerged as a devastating disease in the last 2 years. Many authors appointed to the importance of kallikrein-kinin system (KKS) in COVID-19 pathophysiology as it is involved in inflammation, vascular homeostasis, and coagulation.
Enrique Alfaro +17 more
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Interrelation among exercise training, cardiac hypertrophy, and tissue kallikrein-kinin system in athlete and non-athlete women [PDF]
Journal of Cardiovascular and Thoracic Research, 2022 Introduction: The tissue kallikrein-kinin system is an endogenous homeostatic pathway, which its stimulation is associated with cardioprotection. The present study aimed to determine the effect of exercise training on plasma tissue kallikrein (TK) and ...
Behnam Heidari +4 more
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Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans [PDF]
Frontiers in Physiology, 2017 Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin. In the proximity of its target cells, high molecular weight kininogen (H-kininogen) is the substrate of plasma kallikrein, which releases bradykinin from H ...
Guacyara Motta, Ivarne L. S. Tersariol
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Ex vivo bradykinin as a functional biomarker for angioedema with normal C1-inhibitor [PDF]
Journal of Allergy and Clinical Immunology: GlobalBackground: Bradykinin-mediated angioedema (AE-BK) remains diagnostically challenging particularly in patients with normal C1-inhibitor, where diagnosis primarily relies on clinical criteria. Routine laboratory tests can identify complement deficiency in
Jinguo Chen, MD +6 more
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Editorial: Kallikrein-kinin system: insights into a multifunctional system [PDF]
Frontiers in Physiology, 2023 Guacyara Motta +2 more
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Drugs of the Kallikrein–Kinin System: An Overview
Drugs and Drug Candidates, 2023 The kallikrein–kinin system consists of the two kininogen substrates present in the blood plasma, and two serine proteases: the plasma and tissue kallikreins.
François Marceau
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Kinins and Kinin Receptors in Cardiovascular and Renal Diseases
Pharmaceuticals, 2021 This review addresses the physiological role of the kallikrein–kinin system in arteries, heart and kidney and the consequences of kallikrein and kinin actions in diseases affecting these organs, especially ischemic and diabetic diseases.
Jean-Pierre Girolami +3 more
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