Results 21 to 30 of about 5,170 (128)

Reliable measurement of plasma kinin peptides: Importance of preanalytical variables

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2022
Background The kallikrein‐kinin system is involved in many (patho)physiological processes and kinin peptides are considered potential clinical biomarkers.
Tanja Gangnus, Bjoern B. Burckhardt
doaj   +1 more source

Identification of Human Kinin-Forming Enzyme Inhibitors from Medicinal Herbs

open access: yesMolecules, 2021
The goal of this study was to assess the pharmacological effects of black tea (Camellia sinensis var. assamica) water extract on human kinin-forming enzymes in vitro. Tea is a highly consumed beverage in the world.
Hassan Madkhali   +6 more
doaj   +1 more source

Cardiovascular Activities of of the bradykinin system

open access: yesThe Scientific World Journal, 2008
All the components of the kallikrein-kinin system are located in the cardiac muscle andits deficiency may lead to cardiac dysfunction. In recent years, numerous observationsobtained from clinical and experimental models of diabetes, hypertension ...
Jagdish N. Sharma
doaj   +1 more source

Activity of kallikrein-kinin system of blood and state of placental circulation at full-term pregnancy

open access: yesБюллетень сибирской медицины, 2012
The activity of kallikrein-kinin system of blood and the state of placental circulation at full-term physiological pregnancy have been studied.In 30 pregnant women aged 18—27 at 38th—40th weeks of pregnancy, the activity of  kallikrein-kinin system (KKS)
G. T. Kairov   +2 more
doaj   +1 more source

Safety and Outcomes Associated with the Pharmacological Inhibition of the Kinin–Kallikrein System in Severe COVID-19

open access: yesViruses, 2021
Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major pathological finding in autopsies explaining O2 diffusion failure and hypoxemia ...
Eli Mansour   +19 more
doaj   +1 more source

A Novel Category of Anti-Hypertensive Drugs for Treating Salt-Sensitive Hypertension on the Basis of a New Development Concept

open access: yesPharmaceuticals, 2010
Terrestrial animals must conserve water and NaCl to survive dry environments. The kidney reabsorbs 95% of the sodium filtered from the glomeruli before sodium reaches the distal connecting tubules. Excess sodium intake requires the renal kallikrein-kinin
Masataka Majima, Makoto Katori
doaj   +1 more source

Mutant plasminogen in hereditary angioedema is bypassing FXII/kallikrein to generate bradykinin

open access: yesFrontiers in Physiology, 2023
Hereditary angioedema (HAE) is characterized by recurrent localized edema in various organs, which can be potentially fatal. There are different types of hereditary angioedema, which include genetic deficiency of C1 inhibitor (C1-INH) and hereditary ...
Stefan Hintze   +12 more
doaj   +1 more source

The Kallikrein-Kinin System: Current and Future Pharmacological Targets

open access: yesJournal of Pharmacological Sciences, 2005
The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and
Marie Eve Moreau   +5 more
doaj   +1 more source

The influence of obesity on the parameters of the kallikrein-kinin system and proteolysis in chronic biliary pancreatitis

open access: yesGastroenterologìa
Background. Clinical practice and science have accumulated data that obese patients suffer from severe forms of acute and chronic pancreatitis, which is explained by the accumulation of fat around the pancreas, a decreased activity of pancreatic enzymes.
L.S. Babinets   +2 more
doaj   +1 more source

Optimization of Transfusion Therapy in Peritonitis

open access: yesОбщая реаниматология, 2009
Objective: to develop approaches to therapy for postoperative peritonitis on the basis of an analysis of changes into some indices of the kallikrein-kinin system, such as the key plasma proteolytic system and the blood proteinase potential, in this ...
Ye. V. Ryabikina   +3 more
doaj   +1 more source

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