Results 1 to 10 of about 349 (135)

Drugs of the Kallikrein–Kinin System: An Overview

Drugs and Drug Candidates, 2023
The kallikrein–kinin system consists of the two kininogen substrates present in the blood plasma, and two serine proteases: the plasma and tissue kallikreins.
François Marceau
doaj   +3 more sources

The Kallikrein-Kinin System: Current and Future Pharmacological Targets

Journal of Pharmacological Sciences, 2005
The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and
Marie Eve Moreau, Nancy Garbacki, Giuseppe Molinaro, Nancy J. Brown, François Marceau, Albert Adam   +5 more
doaj   +3 more sources

Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19

EBioMedicine, 2022
Summary: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system.
Caroline P. Martens, Pierre Van Mol, Joost Wauters, Els Wauters, Tanja Gangnus, Bernard Noppen, Hanne Callewaert, Jean H.M. Feyen, Laurens Liesenborghs, Elisabeth Heylen, Sander Jansen, Leydi Carolina Velásquez Pereira, Sirima Kraisin, Ipek Guler, Matthias M. Engelen, Anna Ockerman, Anke Van Herck, Robin Vos, Christophe Vandenbriele, Philippe Meersseman, Greet Hermans, Alexander Wilmer, Kimberly Martinod, Bjoern B. Burckhardt, Marc Vanhove, Marc Jacquemin, Peter Verhamme, Johan Neyts, Thomas Vanassche   +28 more
doaj   +1 more source

Kinins and Kinin Receptors in Cardiovascular and Renal Diseases

Pharmaceuticals, 2021
This review addresses the physiological role of the kallikrein–kinin system in arteries, heart and kidney and the consequences of kallikrein and kinin actions in diseases affecting these organs, especially ischemic and diabetic diseases.
Jean-Pierre Girolami, Nadine Bouby, Christine Richer-Giudicelli, Francois Alhenc-Gelas   +3 more
doaj   +1 more source

Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss. [PDF]

PLoS ONE, 2012
The clinical problem of a "pure volume overload" as in isolated mitral or aortic regurgitation currently has no documented medical therapy that attenuates collagen loss and the resultant left ventricular (LV) dilatation and failure.
Chih-Chang Wei, Yuanwen Chen, Lindsay C Powell, Junying Zheng, Ke Shi, Wayne E Bradley, Pamela C Powell, Sarfaraz Ahmad, Carlos M Ferrario, Louis J Dell'Italia   +9 more
doaj   +1 more source

The kallikrein–kinin system in diabetic nephropathy [PDF]

Kidney International, 2012
Diabetic nephropathy is the major cause of end-stage renal disease worldwide. Although the renin-angiotensin system has been implicated in the pathogenesis of diabetic nephropathy, angiotensin I-converting enzyme (ACE) inhibitors have a beneficial effect on diabetic nephropathy independently of their effects on blood pressure and plasma angiotensin II ...
Tomita, Hirofumi, Sanford, Ryan B., Smithies, Oliver, Kakoki, Masao   +3 more
openaire   +2 more sources

Mechanisms involved in hereditary angioedema with normal C1-inhibitor activity

Frontiers in Physiology, 2023
Patients with the inherited disorder hereditary angioedema (HAE) suffer from episodes of soft tissue swelling due to excessive bradykinin production.
Aleksandr Shamanaev, S. Kent Dickeson, Ivan Ivanov, Maxim Litvak, Mao-Fu Sun, Sunil Kumar, Quifang Cheng, Priyanka Srivastava, Tracey Z. He, David Gailani   +9 more
doaj   +1 more source

Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides

Brazilian Journal of Medical and Biological Research, 2000
The kallikrein-kinin system is complex, with several bioactive peptides that are formed in many different compartments. Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium ...
D.J. Campbell
doaj   +1 more source

Molecular biology of the kallikrein-kinin system: from structure to function

Brazilian Journal of Medical and Biological Research, 1998
The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a ...
J.B. Pesquero, M. Bader
doaj   +1 more source

Kinins’ Contribution to Postoperative Pain in an Experimental Animal Model and Its Implications

Brain Sciences, 2023
Postoperative pain causes discomfort and disability, besides high medical costs. The search for better treatments for this pain is essential to improve recovery and reduce morbidity and risk of chronic postoperative pain.
Indiara Brusco, Cássia Regina Silva, Juliano Ferreira, Sara Marchesan Oliveira   +3 more
doaj   +1 more source