Results 11 to 20 of about 5,170 (128)
Drugs of the Kallikrein–Kinin System: An Overview
Drugs and Drug Candidates, 2023 The kallikrein–kinin system consists of the two kininogen substrates present in the blood plasma, and two serine proteases: the plasma and tissue kallikreins.
François Marceau
doaj +1 more source
Kinins and Kinin Receptors in Cardiovascular and Renal Diseases
Pharmaceuticals, 2021 This review addresses the physiological role of the kallikrein–kinin system in arteries, heart and kidney and the consequences of kallikrein and kinin actions in diseases affecting these organs, especially ischemic and diabetic diseases.
Jean-Pierre Girolami +3 more
doaj +1 more source
Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss. [PDF]
PLoS ONE, 2012 The clinical problem of a "pure volume overload" as in isolated mitral or aortic regurgitation currently has no documented medical therapy that attenuates collagen loss and the resultant left ventricular (LV) dilatation and failure.
Chih-Chang Wei +9 more
doaj +1 more source
Mechanisms involved in hereditary angioedema with normal C1-inhibitor activity
Frontiers in Physiology, 2023 Patients with the inherited disorder hereditary angioedema (HAE) suffer from episodes of soft tissue swelling due to excessive bradykinin production.
Aleksandr Shamanaev +9 more
doaj +1 more source
Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides
Brazilian Journal of Medical and Biological Research, 2000 The kallikrein-kinin system is complex, with several bioactive peptides that are formed in many different compartments. Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium ...
D.J. Campbell
doaj +1 more source
Molecular biology of the kallikrein-kinin system: from structure to function
Brazilian Journal of Medical and Biological Research, 1998 The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a ...
J.B. Pesquero, M. Bader
doaj +1 more source
Kinins’ Contribution to Postoperative Pain in an Experimental Animal Model and Its Implications
Brain Sciences, 2023 Postoperative pain causes discomfort and disability, besides high medical costs. The search for better treatments for this pain is essential to improve recovery and reduce morbidity and risk of chronic postoperative pain.
Indiara Brusco +3 more
doaj +1 more source
New quality criteria for fresh frozen plasma
Медицинский вестник Юга России, 2019 Objective: development of new quality criteria for fresh frozen plasma. Matherials and methods: at diff erent times of storage of fresh frozen plasma harvested standardly and from the donors aft er Biolan exposure, the parameters of the kallikrein-kinin ...
Elena V. Ryabikina +5 more
doaj +1 more source
Gastroenterologìa, 2022 Background. According to evidence, within approximately 8 years, 50 % of patients with chronic pancreatitis (CP) develop endocrine and exocrine insufficiency, which manifests itself as steatorrhea, weight loss, diabetes mellitus (DM), and nutritional ...
L.S. Babinets, I.M. Halabitska
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2009 The generation of bradykinin (BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) in blood and kallidin (Lys-BK) in tissues by the action of the kallikrein-kinin system has received little attention in non-mammalian vertebrates.
B.C. Prezoto +5 more
doaj +1 more source