Results 11 to 20 of about 16,601 (180)

The involvement of proteoglycans in the human plasma prekallikrein interaction with the cell surface. [PDF]

PLoS ONE, 2014
INTRODUCTION: The aim of this work was to evaluate the role of human plasma prekallikrein assembly and processing in cells and to determine whether proteoglycans, along with high molecular weight kininogen (H-kininogen), influence this interaction ...
Camila Lopes Veronez, Fabio D Nascimento, Katia R B Melo, Helena B Nader, Ivarne L S Tersariol, Guacyara Motta   +5 more
doaj   +1 more source

Identification of kininogen-1 as a serum biomarker for the early detection of advanced colorectal adenoma and colorectal cancer. [PDF]

PLoS ONE, 2013
BACKGROUND: Serum markers represent potential tools for the detection of colorectal cancer (CRC). The aim of this study was to obtain proteomic expression profiles and identify serum markers for the early detection of CRC.
Jing Wang, Xinying Wang, Shiyong Lin, Chudi Chen, Congrong Wang, Qunying Ma, Bo Jiang   +6 more
doaj   +1 more source

Candida albicans Biofilm-Derived Extracellular Vesicles Are Involved in the Tolerance to Caspofungin, Biofilm Detachment, and Fungal Proteolytic Activity

Journal of Fungi, 2023
It has been repeatedly reported that the cells of organisms in all kingdoms of life produce nanometer-sized lipid membrane-enveloped extracellular vesicles (EVs), transporting and protecting various substances of cellular origin. While the composition of
Justyna Karkowska-Kuleta, Kamila Kulig, Grazyna Bras, Karolina Stelmaszczyk, Magdalena Surowiec, Andrzej Kozik, Elzbieta Karnas, Olga Barczyk-Woznicka, Ewa Zuba-Surma, Elzbieta Pyza, Maria Rapala-Kozik   +10 more
doaj   +1 more source

The complex role of kininogens in hereditary angioedema

Frontiers in Allergy, 2022
Human high molecular weight kininogen (HK) is the substrate from which bradykinin is released as a result of activation of the plasma “contact” system, a cascade that includes the intrinsic coagulation pathway, and a fibrinolytic pathway leading to the ...
Allen P. Kaplan, Kusumam Joseph, Berhane Ghebrehiwet   +2 more
doaj   +1 more source

Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms

Research and Practice in Thrombosis and Haemostasis, 2022
Background The contact system is initiated by factor (F) XII activation and the assembly of high molecular weight kininogen (HK) with either FXI or prekallikrein (PK) on a negatively charged surface.
Pradeep K. Singh, Zu‐Lin Chen, Katharina Horn, Erin H. Norris   +3 more
doaj   +1 more source

Immunological characterization of rat kininogens with monoclonal antibodies to T‐kininogen. [PDF]

European Journal of Biochemistry, 1992
A panel of 16 monoclonal antibodies (mAb) were produced against rat T‐kininogen to characterize this family of proteins. These mAbs bound 125I‐T‐kininogen by radioimmunoassay as well as reacting strongly with immobilized T‐kininogen in an enzyme‐linked immunosorbent assay (ELISA).
S, Lesage, J, Bouhnik, J P, Richoux, T, Baussant, F, Gauthier, K, Eager, P, Corvol, F, Alhenc-Gelas   +7 more
openaire   +2 more sources

Kininogen–Nitric Oxide Signaling at Nearby Nonexcited Acupoints after Long-Term Stimulation

JID Innovations, 2021
Acupuncture treatment is based on acupoint stimulation; however, the biological basis is not understood. We stimulated one acupoint with catgut embedding for 8 weeks and then used isobaric tags for relative and absolute quantitation to screen proteins ...
Ting Wang, Geng Zhu, Liyue Qin, Qian Wang, Chen She, Dongsheng Xu, Weiwei Hu, Kenghuo Luo, Ying Lei, Yanling Gong, Arijit Ghosh, Dongni Ma, Chun-Lei Ding, Bu-Yi Wang, Yang Guo, Shou-Shan Ma, Michihiro Hattori, Yutaka Takagi, Katsutoshi Ara, Kazuhiko Higuchi, Xingwang Li, Lin He, Wanzhu Bai, Koichi Ishida, Sheng-Tian Li   +24 more
doaj   +1 more source

Kininogen-1 as a protein biomarker for schizophrenia through mass spectrometry and genetic association analyses [PDF]

PeerJ, 2019
Background Schizophrenia (SCZ) is a complex and severe mental illness. There is a lack of effective biomarkers for SCZ diagnosis. The aim of this study was to explore the possibility of using serum peptides for the diagnosis of SCZ as well as analyze the
Mingjia Yang, Na Zhou, Huiping Zhang, Guojun Kang, Bonan Cao, Qi Kang, Rixin Li, Xiaojing Zhu, Wenwang Rao, Qiong Yu   +9 more
doaj   +2 more sources

Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans

Frontiers in Physiology, 2017
Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin. In the proximity of its target cells, high molecular weight kininogen (H-kininogen) is the substrate of plasma kallikrein, which releases bradykinin from H ...
Guacyara Motta, Ivarne L. S. Tersariol
doaj   +1 more source

Structure-function studies using deletion mutants identify domains of gC1qR/p33 as potential therapeutic targets for vascular permeability and inflammation#.

Frontiers in Immunology, 2011
The endothelial cell (EC) receptor complex for kininogen (HK) comprises gC1qR, cytokeratin 1, and urokinase-type plasminogen activator receptor (uPAR) and is essential for activation of the kinin system that leads to bradykinin (BK) generation. Of these,
Berhane eGhebrehiwet, Jolyon eJesty, Sulan eXu, Rama eVinayagasundaram, Uma eVinayagasundaram, Yan eJi, Alisa eValentino, Kinga H. Hosszu, Sally eMathew, Kusumam eJoseph, Allen P. Kaplan, Ellinor I.B. Peerschke   +11 more
doaj   +1 more source