Results 61 to 70 of about 17,108 (133)

Structural requirements for the procoagulant activity of nucleic acids.

PLoS ONE, 2012
Nucleic acids, especially extracellular RNA, are exposed following tissue- or vessel damage and have previously been shown to activate the intrinsic blood coagulation pathway in vitro and in vivo.
Julia Gansler, Miriam Jaax, Silke Leiting, Bettina Appel, Andreas Greinacher, Silvia Fischer, Klaus T Preissner   +6 more
doaj   +1 more source

Changes in the proteomic profile of blood serum in coronary atherosclerosis [PDF]

Journal of Medical Biochemistry, 2020
Background: Our aim was to study changes in the serum proteomic profile in coronary atherosclerosis. Methods: The study involved two groups of patients: 1) men with coronary heart disease and coronary atherosclerosis (n = 15); 2) control (n = 15): men ...
Stakhneva Ekaterina M., Meshcheryakova Irina A., Demidov Evgeny A., Starostin Konstantin V., Peltek Sergey E., Voevoda Michael I., Ragino Yuliya I.   +6 more
doaj  

Cardioprotective effect of ornitho-kinin in an anesthetized, open-chest chicken model of acute coronary occlusion

Brazilian Journal of Medical and Biological Research, 2009
The generation of bradykinin (BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) in blood and kallidin (Lys-BK) in tissues by the action of the kallikrein-kinin system has received little attention in non-mammalian vertebrates.
B.C. Prezoto, G.K. Couto, L.V. Rossoni, G.H.M. Schoorlemmer, B.A. Carillo, R.R. Campos   +5 more
doaj   +1 more source

Inhibiting ADORA1 enhances glioma apoptosis and increases its sensitivity to anti-PD1 therapy

Frontiers in Oncology
IntroductionGlioma, the primary cancerous tumor of the central nervous system in adults, has a poor outlook. Immune checkpoint blockade therapy has exhibited notable efficacy against various cancer types.
Hong-jiang Li, Zhi-yun Yu, Hua-ping Gao, Yi-ran Xu, Xue-yuan Li, Wei Jiang, Di Chen, Dong-ming Yan, Chao Yang, Xian-zhi Liu   +9 more
doaj   +1 more source

An Extensive Study of the Functional Polymorphisms of Kinin-Kallikrein System in Rheumatoid Arthritis Susceptibility

The Turkish Journal of Gastroenterology, 2018
Objectives: This study aims to examine the following functional polymorphisms in rheumatoid arthritis (RA) susceptibility: (i) the 587C>T of kininogen gene, (ii) the 287 bp Alu repeat insertion of angiotensin converting enzyme gene, (iii) the 9 bp ...
Anthoula CHATZIKYRIAKIDOU, Paraskevi V. VOULGARI, Alexandros A. DROSOS   +2 more
doaj  

Dextran sodium sulfate‐induced colitis in male BALB/c mice leads to albuminuria and increased markers of inflammation and tissue damage in the kidney

Physiological Reports
Inflammatory molecules originating from an inflamed gut can promote systemic inflammation. We studied how acute intestinal injury affects the kidneys and the kallikrein‐kinin system in mice with dextran sodium sulfate (DSS)‐induced colitis.
Hanne Salmenkari, Krishna Adeshara, Anniina Pirttiniemi, Jere Lindén, Sanna Lehtonen, Niina Sandholm, Per‐Henrik Groop, Markku Lehto   +7 more
doaj   +1 more source

A novel assay of excess plasma kallikrein-kinin system activation in hereditary angioedema

Frontiers in Allergy
BackgroundCleaved high-molecular-weight kininogen (HKa) is a disease state biomarker of kallikrein-kinin system (KKS) activation in patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH), the endogenous inhibitor of plasma ...
Dan Sexton, Ryan Faucette, Melody Rivera-Hernandez, Jon A. Kenniston, Nikolaos Papaioannou, Janja Cosic, Kris Kopacz, Gary Salmon, Chantal Beauchemin, Salomé Juethner, Dave Yeung   +10 more
doaj   +1 more source

LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study.

PLoS ONE, 2018
Phosphorylation is the most commonly studied protein post-translational modification (PTM) in biological systems due to its importance in controlling cell division, survival, growth, etc.
Asier Galán, Anita Horvatić, Josipa Kuleš, Petra Bilić, Jelena Gotić, Vladimir Mrljak   +5 more
doaj   +1 more source

Prekallikrein: the catalytic crossroads of inflammation and thrombosis. [PDF]

Curr Opin Hematol
Malhotra AK, Tomer A, Punsalan O, Patel N, Moellmer-Gomez SA, Puy C, Shamanaev A, Seifer L, McCarty OJT, Shatzel JJ.   +9 more
europepmc   +1 more source

Therapeutic Targeting of the Bradykinin B2 Receptor in Immunological and Vascular Diseases: Insights from Kinin Biology to Clinical Outcomes. [PDF]

Clin Rev Allergy Immunol
Riedl MA, Cohn DM, Magerl M, Farkas H, Aygören-Pürsün E, Banerji A, Bernstein JA, Schmaier AH, Pardali E, Lesage A, Lu P, Newby DE.   +11 more
europepmc   +1 more source