Results 71 to 80 of about 16,601 (180)

A Novel Category of Anti-Hypertensive Drugs for Treating Salt-Sensitive Hypertension on the Basis of a New Development Concept

open access: yesPharmaceuticals, 2010
Terrestrial animals must conserve water and NaCl to survive dry environments. The kidney reabsorbs 95% of the sodium filtered from the glomeruli before sodium reaches the distal connecting tubules. Excess sodium intake requires the renal kallikrein-kinin
Masataka Majima, Makoto Katori
doaj   +1 more source

Peptide IC-20, encoded by skin kininogen-1 of the European yellow-bellied toad, Bombina variegata, antagonizes bradykinin-induced arterial smooth muscle relaxation

open access: yesJournal of Pharmacy and Bioallied Sciences, 2011
Objectives: The objectives were to determine if the skin secretion of the European yellow-bellied toad (Bombina variegata), in common with other related species, contains a bradykinin inhibitor peptide and to isolate and structurally characterize this ...
Mu Yang   +7 more
doaj   +1 more source

Structural requirements for the procoagulant activity of nucleic acids.

open access: yesPLoS ONE, 2012
Nucleic acids, especially extracellular RNA, are exposed following tissue- or vessel damage and have previously been shown to activate the intrinsic blood coagulation pathway in vitro and in vivo.
Julia Gansler   +6 more
doaj   +1 more source

Changes in the proteomic profile of blood serum in coronary atherosclerosis [PDF]

open access: yesJournal of Medical Biochemistry, 2020
Background: Our aim was to study changes in the serum proteomic profile in coronary atherosclerosis. Methods: The study involved two groups of patients: 1) men with coronary heart disease and coronary atherosclerosis (n = 15); 2) control (n = 15): men ...
Stakhneva Ekaterina M.   +6 more
doaj  

Cardioprotective effect of ornitho-kinin in an anesthetized, open-chest chicken model of acute coronary occlusion

open access: yesBrazilian Journal of Medical and Biological Research, 2009
The generation of bradykinin (BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) in blood and kallidin (Lys-BK) in tissues by the action of the kallikrein-kinin system has received little attention in non-mammalian vertebrates.
B.C. Prezoto   +5 more
doaj   +1 more source

An Extensive Study of the Functional Polymorphisms of Kinin-Kallikrein System in Rheumatoid Arthritis Susceptibility

open access: yesThe Turkish Journal of Gastroenterology, 2018
Objectives: This study aims to examine the following functional polymorphisms in rheumatoid arthritis (RA) susceptibility: (i) the 587C>T of kininogen gene, (ii) the 287 bp Alu repeat insertion of angiotensin converting enzyme gene, (iii) the 9 bp ...
Anthoula CHATZIKYRIAKIDOU   +2 more
doaj  

Inhibiting ADORA1 enhances glioma apoptosis and increases its sensitivity to anti-PD1 therapy

open access: yesFrontiers in Oncology
IntroductionGlioma, the primary cancerous tumor of the central nervous system in adults, has a poor outlook. Immune checkpoint blockade therapy has exhibited notable efficacy against various cancer types.
Hong-jiang Li   +9 more
doaj   +1 more source

LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study.

open access: yesPLoS ONE, 2018
Phosphorylation is the most commonly studied protein post-translational modification (PTM) in biological systems due to its importance in controlling cell division, survival, growth, etc.
Asier Galán   +5 more
doaj   +1 more source

Platelet-kininogen Interactions

open access: yesPlatelets, 1993
S P, Kunapuli, R W, Colman
openaire   +2 more sources

Kininogen [PDF]

open access: yes, 2019
openaire   +1 more source

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