Kinins and Kinin Receptors in Cardiovascular and Renal Diseases [PDF]
Pharmaceuticals, 2021 This review addresses the physiological role of the kallikrein–kinin system in arteries, heart and kidney and the consequences of kallikrein and kinin actions in diseases affecting these organs, especially ischemic and diabetic diseases.
François Alhenc-Gelas +2 more
exaly +7 more sources
The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease [PDF]
Frontiers in Molecular Neuroscience, 2019 Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive spatial disorientation, learning and memory deficits, responsible for 60%–80% of all dementias.
Bingyuan Ji +7 more
doaj +5 more sources
Kinin Receptors and Kinin-Related Gene Expression in Astrocytic Brain Tumors [PDF]
CancersKinins are a set of peptides present in tissues that are involved in the inflammatory response and cancer progression. However, studies showing the expression of kinin receptors in human glioma samples are still incomplete and contradictory. The aim of the present study was to ascertain the expression of BDKRB1 and BDKRB2 genes, as well as the level of
Andrzej Plewka +2 more
exaly +5 more sources
Differential Expression of Kinin Receptors in Human Wet and Dry Age-Related Macular Degeneration Retinae [PDF]
Pharmaceuticals, 2020 Kinins are vasoactive peptides and mediators of inflammation, which signal through two G protein-coupled receptors, B1 and B2 receptors (B1R, B2R). Recent pre-clinical findings suggest a primary role for B1R in a rat model of wet age-related macular ...
Rahmeh Othman +3 more
doaj +2 more sources
Kinins and Their Receptors in Infectious Diseases [PDF]
Pharmaceuticals, 2020 Kinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases.
Ana Paula A. Dagnino +2 more
doaj +3 more sources
Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists [PDF]
Journal of Translational Medicine, 2019 Background Tibial fracture is associated with inflammatory reaction leading to severe pain syndrome. Bradykinin receptor activation is involved in inflammatory reactions, but has never been investigated in fracture pain.
Vincent Minville +7 more
doaj +2 more sources
Malaria infection promotes a selective expression of kinin receptors in murine liver [PDF]
Malaria Journal, 2019 Background Malaria represents a worldwide medical emergency affecting mainly poor areas. Plasmodium parasites during blood stages can release kinins to the extracellular space after internalization of host kininogen inside erythrocytes and these released
Priscilla D. S. Ventura +10 more
doaj +2 more sources
Balance between the two kinin receptors in the progression of experimental focal and segmental glomerulosclerosis in mice [PDF]
Disease Models & Mechanisms, 2014 Focal and segmental glomerulosclerosis (FSGS) is one of the most important renal diseases related to end-stage renal failure. Bradykinin has been implicated in the pathogenesis of renal inflammation, whereas the role of its receptor 2 (B2RBK; also known ...
Rafael Luiz Pereira +16 more
doaj +2 more sources
Kinin B1 Receptor Agonist Enhances Blood-Brain Barrier Permeability in Healthy and Glioblastoma Environments [PDF]
PharmaceuticalsBackground/Objectives: The low permeability of the blood-brain barrier (BBB) represents a significant challenge to effective systemic chemotherapy for primary and metastatic brain cancers.
Carolina Batista +5 more
doaj +2 more sources
Deletion of kinin receptor B2 enhances orthodontic tooth movement and alveolar bone remodeling. [PDF]
PLoS ONEThe kallikrein-kinin system (KKS) is a complex enzymatic system involved in multiple biological processes, particularly inflammation. The system's peptides exert broad effects through two receptors, B1 (B1R) and B2 (B2R), expressed in various cell types,
Natália Couto Figueiredo +9 more
doaj +2 more sources