Results 21 to 30 of about 6,100 (148)
Drugs of the Kallikrein–Kinin System: An Overview
Drugs and Drug Candidates, 2023 The kallikrein–kinin system consists of the two kininogen substrates present in the blood plasma, and two serine proteases: the plasma and tissue kallikreins.
François Marceau
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Molecular biology of the kallikrein-kinin system: from structure to function
Brazilian Journal of Medical and Biological Research, 1998 The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and cardiovascular diseases is still a ...
J.B. Pesquero, M. Bader
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Kinins’ Contribution to Postoperative Pain in an Experimental Animal Model and Its Implications
Brain Sciences, 2023 Postoperative pain causes discomfort and disability, besides high medical costs. The search for better treatments for this pain is essential to improve recovery and reduce morbidity and risk of chronic postoperative pain.
Indiara Brusco +3 more
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Advances in Cancer Biology - Metastasis, 2022 Glioblastoma (GB) is the most aggressive primary tumor of central nervous system, where no efficient therapy has been found so far. This is due to high intra- and inter- tumor heterogeneity, fast invasion and the therapy-resistant subpopulation of GB ...
Mona N. Oliveira +7 more
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Frontiers in Physiology, 2019 The success of the acaricide amitraz, a ligand of the tick tyramine/octopamine receptor (a G protein-coupled receptor; GPCR), stimulated interest on arthropod-specific GPCRs as targets to control tick populations.
Caixing Xiong +2 more
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Journal of Translational Medicine, 2022 Background The kallikrein-kinin system is assumed to have a multifunctional role in health and disease, but its in vivo role in humans currently remains unclear owing to the divergence of plasma kinin level data published ranging from the low picomolar ...
Tanja Gangnus +2 more
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Respiratory Research, 2010 Background Nicotine plays an important role in cigarette-smoke-associated airway disease. The present study was designed to examine if nicotine could induce airway hyperresponsiveness through kinin receptors, and if so, explore the underlying mechanisms ...
Cardell Lars-Olaf, Zhang Yaping, Xu Yuan
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Mediators of Inflammation, 2016 Kinin peptides ubiquitously occur in nervous tissue and participate in inflammatory processes associated with distinct neurological disorders. These substances have also been demonstrated to promote the oxidative stress. On the other hand, the importance
Anna Niewiarowska-Sendo +2 more
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A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors
Pharmaceuticals, 2020 Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention ...
Joseph Lau +4 more
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Biomedicines, 2021 Several stimuli can change maternal hormone levels during pregnancy. These changes may affect trophoblastic cells and modulate the development of the embryo and the placental tissue itself.
Talita Guerreiro Rodrigues Húngaro +6 more
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