Results 41 to 50 of about 6,100 (148)

Renal vasoconstrictive effect of kinins mediated by B1-kinin receptors

European Journal of Pharmacology, 1986
The nature of the renal vascular actions of kinins, their dependence on prostaglandins and B1-kinin receptor responses were studied in functioning isolated perfused rat kidneys (IK). Lysylbradykinin (LBK), 0.28 and 0.7 microM, transiently decreased and then markedly increased the renal vascular resistance (RVR) in a sustained manner. Bradykinin (BK) at
J A, Guimarães, M A, Vieira, M J, Camargo, T, Maack   +3 more
openaire   +2 more sources

Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19

Scientific Reports, 2021
The outbreak of COVID-19 has raised interest in the kinin–kallikrein system. Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the active kinin des-Arg(9)-bradykinin, which thus increasingly activates bradykinin receptors known
Tanja Gangnus, Bjoern B. Burckhardt
doaj   +1 more source

Kinins and Kinin Receptors in Pulmonary Vasoconstriction and Vascular Remodeling

The FASEB Journal, 2012
Kinins are vasoactive peptides that play important roles in vascular homeostasis, inflammation and angiogenesis. Although appreciated for their protective effects on the systemic circulation, kinins may be involved in the development of pulmonary hypertension (PH) as kinin antagonists have been shown to reduce pulmonary arterial ...
Frank K Kuhr, Adrianna M. Zimnicka, Randal A. Skidgel, John W. Christman, Jason X.-J. Yuan, Irena Levitan   +5 more
openaire   +1 more source

Roles of Kinins in the Nervous System

Cell Transplantation, 2015
The kallikrein-kinin system (KKS) is an endogenous pathway involved in many biological processes. Although primarily related to blood pressure control and inflammation, its activation goes beyond these effects.
Priscilla D. Negraes, Cleber A. Trujillo, Micheli M. Pillat, Yang D. Teng, Henning Ulrich   +4 more
doaj   +1 more source

Bradykinin Contributes to Sympathetic and Pressor Responses Evoked by Activation of Skeletal Muscle Afferents P2X in Heart Failure

Cellular Physiology and Biochemistry, 2016
Background/Aims: Published data suggest that purinergic P2X receptors of muscle afferent nerves contribute to the enhanced sympathetic nervous activity (SNA) and blood pressure (BP) responses during static exercise in heart failure (HF).
Jihong Xing, Jianhua Li
doaj   +1 more source

Kinin receptors as targets for cancer therapy

Expert Opinion on Therapeutic Targets, 2012
Biological fluids of cancer patients contain increased levels of kinins. Activation of kinin B1 and B2 receptors expressed on cancer cells produce an increase in cell proliferation, migration of tumor cells and release of MMPs, which are cellular and molecular events of primary importance for tumor growth.
Figueroa, Carlos D., Ehrenfeld, Pamela, Bhoola, Kanti D.   +2 more
openaire   +6 more sources

Kinin B₁ receptors mediate depression-like behavior response in stressed mice treated with systemic E. coli lipopolysaccharide

Journal of Neuroinflammation, 2010
Background Kinin B1 receptors are inducible molecules up-regulated after inflammatory stimuli. This study evaluated the relevance of kinin B1 receptors in a mouse depression behavior model.
Campos Maria M, Siqueira Jarbas M, Figueiredo Claudia P, Dornelles Fabiana N, Maciel Izaque S, Viana Alice F, Calixto João B   +6 more
doaj   +1 more source

Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer’s Disease Pathological Characteristics in a Transgenic Mouse Model

Pharmaceuticals, 2020
Background: Alzheimer’s disease is mainly characterized by remarkable neurodegeneration in brain areas related to memory formation. This progressive neurodegeneration causes cognitive impairment, changes in behavior, functional disability, and even death.
Marielza Andrade Nunes, Mariana Toricelli, Natalia Mendes Schöwe, Helena Nascimento Malerba, Karis Ester Dong-Creste, Daniela Moura Azevedo Tuma Farah, Katia De Angelis, Maria Claudia Irigoyen, Fernand Gobeil, Tânia Araujo Viel, Hudson Sousa Buck   +10 more
doaj   +1 more source

Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice

Frontiers in Aging Neuroscience, 2019
Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS)
Mariana Toricelli, Mariana Toricelli, Sebastiana Ribeiro Evangelista, Sebastiana Ribeiro Evangelista, Larissa Rolim Oliveira, Tania Araujo Viel, Tania Araujo Viel, Hudson Sousa Buck, Hudson Sousa Buck   +8 more
doaj   +1 more source

Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors. [PDF]

Inflamm Res, 2023
Martins L, Amorim WW, Gregnani MF, de Carvalho Araújo R, Qadri F, Bader M, Pesquero JB.   +6 more
europepmc   +1 more source