Results 31 to 40 of about 6,100 (148)

Vascular risk factors for COVID-19 ARDS: endothelium, contact-kinin system

Frontiers in Medicine, 2023
SARS-CoV-2 binds to ACE2 receptors, expressed within the lungs. Risk factors for hospitalization include hypertension, diabetes, ischaemic heart disease and obesity–conditions linked by the presence of endothelial pathology.
Melanie Bailey, Dermot Linden, Dermot Linden, Hong Guo-Parke, Olivia Earley, Tunde Peto, Tunde Peto, Danny F. McAuley, Danny F. McAuley, Clifford Taggart, Joseph Kidney   +10 more
doaj   +1 more source

The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: Evidence for the involvement of astrocytes

Neurobiology of Disease, 2013
Multiple sclerosis (MS) is a progressive, demyelinating inflammatory disease of the human central nervous system (CNS). While the primary symptoms of MS affect motor function, it is now recognized that chronic pain is a relevant symptom that affects both
Rafael C. Dutra, Allisson F. Bento, Daniela F.P. Leite, Marianne N. Manjavachi, Rodrigo Marcon, Maíra Assunção Bicca, João B. Pesquero, João B. Calixto   +7 more
doaj   +1 more source

Kinin B₁ receptors contributes to acute pain following minor surgery in humans

Molecular Pain, 2010
Background Kinins play an important role in regulation of pain and hyperalgesia after tissue injury and inflammation by activating two types of G-protein-coupled receptors, the kinin B1 and B2 receptors.
Brahim Jaime S, Adam Albert, Wang Xiao-Min, Hamza May, Rowan Janet S, Carmona Gilberto N, Dionne Raymond A   +6 more
doaj   +1 more source

Regulation of the kinin receptors after induction of myocardial infarction: a mini-review

Brazilian Journal of Medical and Biological Research, 2000
It is well known that the responses to vasoactive kinin peptides are mediated through the activation of two receptors termed bradykinin receptor B1 (B1R) and B2 (B2R).
C. Tschöpe, S. Heringer-Walther, T. Walther   +2 more
doaj   +1 more source

A Novel Category of Anti-Hypertensive Drugs for Treating Salt-Sensitive Hypertension on the Basis of a New Development Concept

Pharmaceuticals, 2010
Terrestrial animals must conserve water and NaCl to survive dry environments. The kidney reabsorbs 95% of the sodium filtered from the glomeruli before sodium reaches the distal connecting tubules. Excess sodium intake requires the renal kallikrein-kinin
Masataka Majima, Makoto Katori
doaj   +1 more source

Distinct kinin-induced functions are altered in circulating cells of young type 1 diabetic patients. [PDF]

PLoS ONE, 2010
We aimed to understand early alterations in kinin-mediated migration of circulating angio-supportive cells and dysfunction of kinin-sensitive cells in type-1 diabetic (T1D) patients before the onset of cardiovascular disease.Total mononuclear cells (MNC)
Nicolle Kränkel, Stephen Paul Armstrong, Craig Alexander McArdle, Colin Dayan, Paolo Madeddu   +4 more
doaj   +1 more source

Molecular mechanisms for subtype selectivity of kinin receptors’ antagonists

Nature Communications
The kinin receptors B1R and B2R act as key regulators within the kallikrein–kinin system, mediating vasodilation, inflammation, and pain. Antagonists targeting these receptors have shown therapeutic potential in the treatment of angioedema, pancreatitis,
Meng Xia, Aleksey Raskovalov, My V. T. Nguyen, Shiliu Mei, Donggyun Kim, Jayden Salve, Vsevolod Katritch, Vadim Cherezov, Haitao Zhang   +8 more
doaj   +1 more source

The Kallikrein-Kinin System: Current and Future Pharmacological Targets

Journal of Pharmacological Sciences, 2005
The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and
Marie Eve Moreau, Nancy Garbacki, Giuseppe Molinaro, Nancy J. Brown, François Marceau, Albert Adam   +5 more
doaj   +1 more source

The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model

BMC Cancer, 2018
Background The Kallikrein-Kinin System (KKS) has been found to play a role in tumor progression in several cancers. The KKS metabolic cascade depends on signalling through two cross talking receptors; bradykinin receptor 1 (B1R) and bradykinin receptor 2
Patricia Luiza Nunes da Costa, David Wynne, Theodora Fifis, Linh Nguyen, Marcos Perini, Christopher Christophi   +5 more
doaj   +1 more source

Mechanisms involved in the nociception triggered by the venom of the armed spider Phoneutria nigriventer.

PLoS Neglected Tropical Diseases, 2013
BackgroundThe frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents.
Camila Gewehr, Sara Marchesan Oliveira, Mateus Fortes Rossato, Gabriela Trevisan, Gerusa Duarte Dalmolin, Flávia Karine Rigo, Célio José de Castro Júnior, Marta Nascimento Cordeiro, Juliano Ferreira, Marcus V Gomez   +9 more
doaj   +1 more source