Results 11 to 20 of about 6,100 (148)

Kinin B1- and B2-Receptor Subtypes Contract Isolated Bovine Ciliary Muscle: Their Role in Ocular Lens Function and Intraocular Pressure Reduction [PDF]

Pharmaceuticals
Background: Bradykinin is an endogenously produced nonapeptide with many physiological and pathological functions that are mediated by two pharmacologically defined receptor subtypes, B1- and B2-receptors.
Najam A. Sharif, Madura Kulkarni-Chitnis, Anthonia Okolie, Ya Fatou Njie-Mbye, Sunny E. Ohia   +4 more
doaj   +2 more sources

Kinin B₂ Receptor Mediates Cisplatin-Induced Painful Peripheral Neuropathy by Intracellular Kinase Pathways and TRPA1 Channel Sensitisation

Pharmaceuticals, 2023
Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology is poorly understood, it is known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1 ...
Gabriela Becker, Maria Fernanda Pessano Fialho, Evelyne Silva Brum, Sara Marchesan Oliveira   +3 more
doaj   +1 more source

Kinin B1 and B2 receptors mediate cancer pain associated with both the tumor and oncology therapy using aromatase inhibitors

Scientific Reports, 2023
Pain caused by the tumor or aromatase inhibitors (AIs) is a disabling symptom in breast cancer survivors. Their mechanisms are unclear, but pro-algesic and inflammatory mediators seem to be involved.
Indiara Brusco, Gabriela Becker, Tais Vidal Palma, Micheli Mainardi Pillat, Rahisa Scussel, Bethina Trevisol Steiner, Tuane Bazanella Sampaio, Daniel Mendes Pereira Ardisson-Araújo, Cinthia Melazzo de Andrade, Mauro Schneider Oliveira, Ricardo Andrez Machado-De-Avila, Sara Marchesan Oliveira   +11 more
doaj   +1 more source

Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies

Cells, 2021
The kallikrein-kinin system (KKS) contributes to retinal inflammation and neovascularization, notably in diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD).
Rahmeh Othman, Gael Cagnone, Jean-Sébastien Joyal, Elvire Vaucher, Réjean Couture   +4 more
doaj   +1 more source

Kinin B₁ and B₂ Receptors Contribute to Cisplatin-Induced Painful Peripheral Neuropathy in Male Mice

Pharmaceutics, 2023
Cisplatin is the preferential chemotherapeutic drug for highly prevalent solid tumours. However, its clinical efficacy is frequently limited due to neurotoxic effects such as peripheral neuropathy.
Gabriela Becker, Maria Fernanda Pessano Fialho, Indiara Brusco, Sara Marchesan Oliveira   +3 more
doaj   +1 more source

Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes. [PDF]

PLoS ONE, 2012
The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins and des-Arg-kinins are the major effectors of this system and promote their effects by binding ...
Carlos C Barros, Anderson Haro, Fernanda J V P Russo, Ines Schadock, Sandro S Almeida, Rosane A Ribeiro, Emerielle C Vanzela, Valeria P Lanzoni, Flavio C Barros, Milton R Moraes, Marcelo A Mori, Reury F P Bacurau, Martin Wurtele, Antônio C Boschero, Everardo M Carneiro, Michael Bader, Joao B Pesquero, Ronaldo C Araujo   +17 more
doaj   +1 more source

Classification of Kinin Receptors

Biological Chemistry, 2001
AbstractThis minireview is divided into three parts: the first part refers to the characterization and classification of kinin receptors using agonists and antagonists in isolated tissues (classical pharmacology). Two kinin receptors have been considered on the basis of their distinct pharmacology, namely the B1receptor of the rabbit aorta (rank order ...
D, Regoli, A, Rizzi, S I, Perron, F, Gobeil   +3 more
openaire   +4 more sources

Kinin B1 receptor in adipocytes regulates glucose tolerance and predisposition to obesity. [PDF]

PLoS ONE, 2012
BACKGROUND: Kinins participate in the pathophysiology of obesity and type 2 diabetes by mechanisms which are not fully understood. Kinin B(1) receptor knockout mice (B(1) (-/-)) are leaner and exhibit improved insulin sensitivity.
Marcelo A Mori, Vicência Micheline Sales, Fabiana Louise Motta, Raphael Gomes Fonseca, Natalia Alenina, Dioze Guadagnini, Ines Schadock, Elton Dias Silva, Hugo A M Torres, Edson Lucas dos Santos, Charlles Heldan Castro, Vânia D'Almeida, Sandra Andreotti, Amanda Baron Campaña, Rogério A L Sertié, Mario J A Saad, Fabio Bessa Lima, Michael Bader, João Bosco Pesquero   +18 more
doaj   +1 more source

Vascular Kinin B1 and B2 Receptors Determine Endothelial Dysfunction through Neuronal Nitric Oxide Synthase

Frontiers in Physiology, 2017
B1- and B2-kinin receptors are G protein-coupled receptors that play an important role in the vascular function. Therefore, the present study was designed to evaluate the participation of kinin receptors in the acetylcholine (ACh)-induced vascular ...
Luciano Dos Santos A. Capettini, Sandra Lauton-Santos, Thássio R. R. Mesquita, Gianne P. Campos-Mota, Virgínia S. Lemos, Jader S. Cruz, Itamar C. G. de Jesus, Enilton A. Camargo, Jorge L. Pesquero, João B. Pesquero   +9 more
doaj   +1 more source

Pharmacological Modulation of Blood–Brain Barrier Permeability by Kinin Analogs in Normal and Pathologic Conditions

Pharmaceuticals, 2020
The blood–brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous system diseases. Peptide agonist analogs of kinin B1 and B2 receptors, acting as BBB permeabilizers,
Dina Sikpa, Lisa Whittingstall, Martin Savard, Réjean Lebel, Jérôme Côté, Stephen McManus, Sylvain Chemtob, David Fortin, Martin Lepage, Fernand Gobeil   +9 more
doaj   +1 more source