Results 1 to 10 of about 21,157 (118)

Bradykinin reduces wound healing in human umbilical vein endothelial cells via downregulation of vascular endothelial growth factor A [PDF]

Journal of Inflammation
Introduction Hereditary angioedema (HAE) is characterized by acute swelling attacks triggered by abnormally elevated levels of bradykinin. Despite persistently high bradykinin levels, patients experience only intermittent swelling episodes.
Nevena Dimitrova, Angelina Gierke, Raphael Möhrle, Julia Nemeth, Cornelia Brunner, Thomas K. Hoffmann, Jens Greve, Janina Hahn, Robin Lochbaum   +8 more
doaj   +2 more sources

Association between Toll-like receptor 9 signaling defect and developing post-infectious irritable bowel syndrome [PDF]

Frontiers in Immunology
IntroductionPost-infectious irritable bowel syndrome (PI-IBS) is a functional gastrointestinal disorder that develops after intestinal infection. A follow-up study after a waterborne outbreak of gastroenteritis indicated involvement of specific genetic ...
Satoshi Kotani, Yoshiyuki Mishima, Kenichi Kishimoto, Akihiko Oka, Naoki Oshima, Kousaku Kawashima, Kenjiro Matsumoto, Haruki Usuda, Koichiro Wada, Shunji Ishihara   +9 more
doaj   +2 more sources

The Role of Bradykinin Receptors in the Etiopathogenesis of Chronic Spontaneous Urticaria

Medicina, 2021
Background and Objectives: Chronic spontaneous urticaria (CSU) is a distressing skin condition, which manifests as red, swollen, itchy, and sometimes painful hives or wheals appearing on skin.
Aleksander Obtulowicz, Pawel Dubiela, Wojciech Dyga, Kamila Migacz-Gruszka, Tomasz Mikolajczyk, Anna Wojas-Pelc, Krystyna Obtulowicz   +6 more
doaj   +1 more source

The Bradykinin System Contributes to the Regulation of Prostaglandin-Endoperoxide Synthase 2 Expression in Human Amnion Fibroblasts: Implications for Term and Preterm Birth

Frontiers in Endocrinology, 2022
BackgroundBradykinin (BK) and its biologically active metabolite des-Arg9 bradykinin (DABK) play a pivotal role in inflammation. Since chorioamnionitis is the leading cause of preterm birth and prostaglandin E2 (PGE2) derived from the amnion is key to ...
Xiao-tian Ni, Wang-sheng Wang, Wang-sheng Wang, Yun Liu, Yi-kai Lin, Yi-kai Lin, Fan Zhang, Fan Zhang, Wen-jia Lei, Wen-jia Lei, Li-jun Ling, Fan Pan, Fan Pan, Ya-nan Zhu, Ya-nan Zhu, Meng-die Li, Meng-die Li, Tao Duan, Ming Liu, Kang Sun, Kang Sun   +20 more
doaj   +1 more source

Molecular Features of Non-Selective Small Molecule Antagonists of the Bradykinin Receptors

Pharmaceuticals, 2020
Angiotensin converting enzyme 2 (ACE2) downregulation is a key negative factor for the severity of lung edema and acute lung failure observed in patients infected with SARS-CoV-2. ACE2 downregulation affects the levels of diverse peptide mediators of the
Bahareh Rasaeifar, Patricia Gomez-Gutierrez, Juan J. Perez   +2 more
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A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors

Pharmaceuticals, 2020
Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention ...
Joseph Lau, Julie Rousseau, Daniel Kwon, François Bénard, Kuo-Shyan Lin   +4 more
doaj   +1 more source

Effect of 3-substituted 1,4-benzodiazepin-2-ones on bradykinin-induced smooth muscle contraction [PDF]

The Ukrainian Biochemical Journal, 2017
Biochemical properties of 3-substituted 1,4-benzodiazepine determined by the characteristics of their chemical structure. Influence of 3-substituted 1,4-benzodiazepin-2-ones on maximal normalized rate and amplitudes of isometric smooth muscle contraction
P. A. Virych, O. V. Shelyuk, T. A. Kabanova, E. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati   +6 more
doaj   +1 more source

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

eLife, 2020
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we present a novel molecular mechanism for COVID-19 that provides therapeutic intervention points that can be addressed with existing FDA-approved pharmaceuticals.
Michael R Garvin, Christiane Alvarez, J Izaak Miller, Erica T Prates, Angelica M Walker, B Kirtley Amos, Alan E Mast, Amy Justice, Bruce Aronow, Daniel Jacobson   +9 more
doaj   +1 more source

Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19

Scientific Reports, 2021
The outbreak of COVID-19 has raised interest in the kinin–kallikrein system. Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the active kinin des-Arg(9)-bradykinin, which thus increasingly activates bradykinin receptors known
Tanja Gangnus, Bjoern B. Burckhardt
doaj   +1 more source

Ex Vivo Smooth Muscle Pharmacological Effects of a Novel Bradykinin-Related Peptide, and Its Analogue, from Chinese Large Odorous Frog, Odorrana livida Skin Secretions

Toxins, 2016
Bradykinin-related peptides (BRPs) are one of the most extensively studied frog secretions-derived peptide families identified from many amphibian species.
Jie Xiang, Hui Wang, Chengbang Ma, Mei Zhou, Yuxin Wu, Lei Wang, Shaodong Guo, Tianbao Chen, Chris Shaw   +8 more
doaj   +1 more source