Molecular Features of Non-Selective Small Molecule Antagonists of the Bradykinin Receptors [PDF]
Pharmaceuticals, 2020 Angiotensin converting enzyme 2 (ACE2) downregulation is a key negative factor for the severity of lung edema and acute lung failure observed in patients infected with SARS-CoV-2. ACE2 downregulation affects the levels of diverse peptide mediators of the
Bahareh Rasaeifar +2 more
doaj +4 more sources
The Role of Bradykinin Receptors in the Etiopathogenesis of Chronic Spontaneous Urticaria [PDF]
Medicina, 2021 Background and Objectives: Chronic spontaneous urticaria (CSU) is a distressing skin condition, which manifests as red, swollen, itchy, and sometimes painful hives or wheals appearing on skin.
Aleksander Obtulowicz +6 more
doaj +2 more sources
A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors
Pharmaceuticals, 2020 Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention ...
Joseph Lau +4 more
doaj +3 more sources
fMRI Reveals Mitigation of Cerebrovascular Dysfunction by Bradykinin Receptors 1 and 2 Inhibitor Noscapine in a Mouse Model of Cerebral Amyloidosis [PDF]
Frontiers in Aging Neuroscience, 2019 Functional magnetic resonance imaging (fMRI) techniques can be used to assess cerebrovascular dysfunction in Alzheimer’s disease, an important and early contributor to pathology. We hypothesized that bradykinin receptor inhibition alleviates the vascular
Ruiqing Ni +16 more
doaj +2 more sources
Kinins Released by Erythrocytic Stages of Plasmodium falciparum Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors [PDF]
Frontiers in Medicine, 2019 Background:Plasmodium falciparum, the etiologic agent of malaria, is a major cause of infant death in Africa. Although research on the contact system has been revitalized by recent discoveries in the field of thrombosis, limited efforts were done to ...
Leandro S. Silva +8 more
doaj +2 more sources
Bradykinin reduces wound healing in human umbilical vein endothelial cells via downregulation of vascular endothelial growth factor A [PDF]
Journal of InflammationIntroduction Hereditary angioedema (HAE) is characterized by acute swelling attacks triggered by abnormally elevated levels of bradykinin. Despite persistently high bradykinin levels, patients experience only intermittent swelling episodes.
Nevena Dimitrova +8 more
doaj +2 more sources
Bradykinin-bradykinin 2 receptor and oxidative stress. [PDF]
Ann MedBradykinin (BK) and its primary receptor, the bradykinin 2 receptor (B2R), play pivotal roles in regulating oxidative stress. While B2R activation has traditionally been linked to elevated reactive oxygen species (ROS) and pro-apoptotic signalling, growing evidence indicates that, under specific contexts, it also exerts antioxidative and cytoprotective
Zhao J +7 more
europepmc +3 more sources
The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency [PDF]
International Journal of Molecular Sciences, 2022 Pawel Dubiela +2 more
exaly +2 more sources
Association between Toll-like receptor 9 signaling defect and developing post-infectious irritable bowel syndrome [PDF]
Frontiers in ImmunologyIntroductionPost-infectious irritable bowel syndrome (PI-IBS) is a functional gastrointestinal disorder that develops after intestinal infection. A follow-up study after a waterborne outbreak of gastroenteritis indicated involvement of specific genetic ...
Satoshi Kotani +9 more
doaj +2 more sources
Frontiers in Endocrinology, 2022 BackgroundBradykinin (BK) and its biologically active metabolite des-Arg9 bradykinin (DABK) play a pivotal role in inflammation. Since chorioamnionitis is the leading cause of preterm birth and prostaglandin E2 (PGE2) derived from the amnion is key to ...
Xiao-tian Ni +20 more
doaj +1 more source