Results 31 to 40 of about 21,207 (157)
Arteriogenesis Is Modulated By Bradykinin Receptor Signaling [PDF]
Circulation Research, 2011 Rationale: Positive outward remodeling of pre-existing collateral arteries into functional conductance arteries, arteriogenesis, is a major endogenous rescue mechanism to prevent cardiovascular ischemia. Collateral arterial growth is accompanied by expression of kinin precursor.
Philipp, Hillmeister +18 more
openaire +2 more sources
Regulatory Mechanisms in Biosystems, 2017 Damage to tissue, inflammation and disruption of normal functioning of organs are often accompanied by pain. In pain perceptions, the kinin-kallikrein system with bradykinin as mediator is very important.
P. A. Virych +6 more
doaj +1 more source
Renoprotective impact of angiotensin 1-7: Is it certain? [PDF]
Journal of Nephropathology, 2019 The two important arms of renin angiotensin system (RAS) are angiotensin II (Ang II) and angiotensin1-7 (Ang1-7). Both of these peptides are present in the kidney, while the renal hemodynamic responses to these peptides act differently in kidney ...
Mehdi Nematbakhsh
doaj +1 more source
Does hereditary angioedema make COVID-19 worse?
World Allergy Organization Journal, 2020 The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19, enters host cells via angiotensin-converting enzyme 2 (ACE2) and depletes ACE2,
Yingyang Xu +3 more
doaj +1 more source
Bradykinin receptors as a therapeutic target
Expert Opinion on Therapeutic Targets, 2003 Biologically-active kinins, including bradykinin (BK) and Lys(0)-BK (kallidin), are short-lived peptide mediators predominantly generated by the enzymatic action of kallikreins on kininogen precursors. A diverse spectrum of physiological and pathological actions attributed to local kinin production is a consequence of the activation of G-protein ...
Howl, John D., Payne, Sarah J.
openaire +4 more sources
Receptor mechanism of infarct-limiting effect of adaptation to normobaric hypoxia
Бюллетень сибирской медицины, 2021 The aim of the study was to investigate the involvement of bradykinin, cannabinoid and vanilloid (TRPV1 channel) receptors in the implementation of the infarct-limiting effect of chronic normobaric hypoxia (CNH).Materials and methods.
N. V. Naryzhnaya +3 more
doaj +1 more source
Pain Research and Management, 2018 Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways.
Zainul Amiruddin Zakaria +8 more
doaj +1 more source
Neuroprotection of bradykinin/bradykinin B2 receptor system in cerebral ischemia
Biomedicine & Pharmacotherapy, 2017 Bradykinin B2 receptor (B2R) activated by its endogenous ligand bradykinin participates in various physiological processes including neurogenesis, neuronal differentiation, and control of inflammation and blood pressure. Besides these effects, B2R has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury.
Bingyuan, Ji +5 more
openaire +2 more sources
NeurogliaGlioblastomas synthesize, bear receptors for, and respond to bradykinin, triggering migration and proliferation. Since centrifugal migration into uninvolved surrounding brain tissue occurs early in the course of glioblastoma, this attribute defeats local
Richard E. Kast
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The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice
Frontiers in Immunology, 2018 The kallikrein–kinin system (KKS) consists of two serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-molecular-weight kininogen (HK). Upon activation of the KKS, HK is cleaved to release bradykinin.
Bo Wang +9 more
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