Results 11 to 20 of about 21,207 (157)

Effect of 3-substituted 1,4-benzodiazepin-2-ones on bradykinin-induced smooth muscle contraction [PDF]

The Ukrainian Biochemical Journal, 2017
Biochemical properties of 3-substituted 1,4-benzodiazepine determined by the characteristics of their chemical structure. Influence of 3-substituted 1,4-benzodiazepin-2-ones on maximal normalized rate and amplitudes of isometric smooth muscle contraction
P. A. Virych, O. V. Shelyuk, T. A. Kabanova, E. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati   +6 more
doaj   +1 more source

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

eLife, 2020
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we present a novel molecular mechanism for COVID-19 that provides therapeutic intervention points that can be addressed with existing FDA-approved pharmaceuticals.
Michael R Garvin, Christiane Alvarez, J Izaak Miller, Erica T Prates, Angelica M Walker, B Kirtley Amos, Alan E Mast, Amy Justice, Bruce Aronow, Daniel Jacobson   +9 more
doaj   +1 more source

Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19

Scientific Reports, 2021
The outbreak of COVID-19 has raised interest in the kinin–kallikrein system. Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the active kinin des-Arg(9)-bradykinin, which thus increasingly activates bradykinin receptors known
Tanja Gangnus, Bjoern B. Burckhardt
doaj   +1 more source

Involvement of bradykinin and bradykinin B1 receptor in patients with endometriosis

Experimental and Therapeutic Medicine, 2021
Endometriosis (EM), a benign aseptic inflammatory disease, is associated with the presence of endometrial foci. Pain, one of its typical symptoms, has been reported as a constant stressor, but the etiology and pathogenesis of EM-associated pain are unclear.
Meng, Xin, Li, Ying, Li, Qingxue, Yang, Jian, An, Mingli, Fu, Xinping, Zhang, Shuancheng, Chen, Jingwei   +7 more
openaire   +3 more sources

Ex Vivo Smooth Muscle Pharmacological Effects of a Novel Bradykinin-Related Peptide, and Its Analogue, from Chinese Large Odorous Frog, Odorrana livida Skin Secretions

Toxins, 2016
Bradykinin-related peptides (BRPs) are one of the most extensively studied frog secretions-derived peptide families identified from many amphibian species.
Jie Xiang, Hui Wang, Chengbang Ma, Mei Zhou, Yuxin Wu, Lei Wang, Shaodong Guo, Tianbao Chen, Chris Shaw   +8 more
doaj   +1 more source

Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation

Cell Reports, 2019
Summary: Activation of Gαq-coupled receptors by inflammatory mediators inhibits cold-sensing TRPM8 channels, aggravating pain and inflammation. Both Gαq and the downstream hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) inhibit TRPM8. Here, I
Xuming Zhang
doaj   +1 more source

Bradykinin receptors in intestinal smooth muscles and their post-receptor events related to calcium

Mediators of Inflammation, 1993
The effects of trifluoperazine and verapamil on bradykinin- and des-Arg9-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events.
Yusuf Öztürk, V. Melih Altan, Nuray Yıdızoğlu-Arı, Orhan Altınkurt   +3 more
doaj   +1 more source

Kinin B₂ Receptor Mediates Cisplatin-Induced Painful Peripheral Neuropathy by Intracellular Kinase Pathways and TRPA1 Channel Sensitisation

Pharmaceuticals, 2023
Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology is poorly understood, it is known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1 ...
Gabriela Becker, Maria Fernanda Pessano Fialho, Evelyne Silva Brum, Sara Marchesan Oliveira   +3 more
doaj   +1 more source

Roles for the Kallikrein-Kinin System in Inflammatory Exudation and Pain: Lessons From Studies on Kininogen-Deficient Rats

Journal of Pharmacological Sciences, 2003
: Roles for the kallikrein-kinin system in inflammation have been investigated extensively, and many reviews on this topic have been published during the 50 years since the discovery of bradykinin in 1949. Recent progress in the field has been remarkable
Akinori Ueno, Sachiko Oh-ishi
doaj   +1 more source

Bradykinin and adenosine receptors mediate desflurane induced postconditioning in human myocardium: role of reactive oxygen species

BMC Anesthesiology, 2010
Background Desflurane during early reperfusion has been shown to postcondition human myocardium, in vitro. We investigated the role of adenosine and bradykinin receptors, and generation of radical oxygen species in desflurane-induced postconditioning in ...
Gérard Jean-Louis, Massetti Massimo, Babatasi Gérard, Ivascau Calin, Rouet René, Buléon Clément, Lemoine Sandrine, Hanouz Jean-Luc   +7 more
doaj   +1 more source