Results 41 to 50 of about 567,455 (203)

Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis

Frontiers in Pharmacology, 2018
Bone marrow metastasis occurs in approximately 350,000 patients that annually die in the U.S. alone. In view of the importance of tumor cell migration into the bone marrow, we have here investigated effects of various concentrations of stromal cell ...
Henning Ulrich, Mariusz Z. Ratajczak, Mariusz Z. Ratajczak, Gabriela Schneider, Elena Adinolfi, Elisa Orioli, Enéas G. Ferrazoli, Talita Glaser, Juliana Corrêa-Velloso, Poliana C. M. Martins, Fernanda Coutinho, Ana P. J. Santos, Micheli M. Pillat, Ulrich Sack, Claudiana Lameu   +14 more
doaj   +1 more source

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells [PDF]

, 2014
Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2.
Ramadass, M, Kishore, U, Ji, Y, Pednekar, L, Peerschke, EIB, Ghebrehiwet, B, David, H, Galanakis, DK, Valentino, A, Kew, RR, Hosszu, KH   +10 more
core   +1 more source

Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax plancyi fukienensis: A Prototype of a Novel Class of Bradykinin B2 Receptor Antagonist Peptide from Ranid Frogs

The Scientific World Journal, 2014
The defensive skin secretions of many amphibians are a rich source of bradykinins and bradykinin-related peptides (BRPs). Members of this peptide group are also common components of reptile and arthropod venoms due to their multiple biological functions
Jie Ma, Yu Luo, Lilin Ge, Lei Wang, Mei Zhou, Yingqi Zhang, Jinao Duan, Tianbao Chen, Chris Shaw   +8 more
doaj   +1 more source

Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor

Frontiers in Endocrinology, 2022
The angiotensin type 2 (AT2) receptor and the bradykinin type 2 (B2) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at various levels, and there is
Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Elizabeth K. M. Johnstone, Mohammed Akli Ayoub, Mohammed Akli Ayoub, Rebecca J. Hertzman, Rebecca J. Hertzman, Heng B. See, Heng B. See, Rekhati S. Abhayawardana, Rekhati S. Abhayawardana, Ruth M. Seeber, Ruth M. Seeber, Kevin D. G. Pfleger, Kevin D. G. Pfleger, Kevin D. G. Pfleger   +15 more
doaj   +1 more source

Bradykinin-bradykinin 2 receptor and oxidative stress

Annals of Medicine
Bradykinin (BK) and its primary receptor, the bradykinin 2 receptor (B2R), play pivotal roles in regulating oxidative stress. While B2R activation has traditionally been linked to elevated reactive oxygen species (ROS) and pro-apoptotic signalling, growing evidence indicates that, under specific contexts, it also exerts antioxidative and cytoprotective
Zhao, Jun, Wang, Zhuanping, Wang, Xuetao, Yang, Fangjun, Xi, Huirong, Wen, Jiantao, Zhang, Wenjing, Qiu, Xiaoming   +7 more
openaire   +2 more sources

Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways

Respiratory Research, 2010
Background Nicotine plays an important role in cigarette-smoke-associated airway disease. The present study was designed to examine if nicotine could induce airway hyperresponsiveness through kinin receptors, and if so, explore the underlying mechanisms ...
Cardell Lars-Olaf, Zhang Yaping, Xu Yuan
doaj   +1 more source

Effect of 3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine-2-ones on the bradykinin-induced smooth muscle contraction

Regulatory Mechanisms in Biosystems, 2017
Damage to tissue, inflammation and disruption of normal functioning of organs are often accompanied by pain. In pain perceptions, the kinin-kallikrein system with bradykinin as mediator is very important.
P. A. Virych, O. V. Shelyuk, T. A. Kabanova, O. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati   +6 more
doaj   +1 more source

Does hereditary angioedema make COVID-19 worse?

World Allergy Organization Journal, 2020
The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for COVID-19, enters host cells via angiotensin-converting enzyme 2 (ACE2) and depletes ACE2,
Yingyang Xu, Shuang Liu, Yan Zhang, Yuxiang Zhi   +3 more
doaj   +1 more source

Renoprotective impact of angiotensin 1-7: Is it certain? [PDF]

Journal of Nephropathology, 2019
The two important arms of renin angiotensin system (RAS) are angiotensin II (Ang II) and angiotensin1-7 (Ang1-7). Both of these peptides are present in the kidney, while the renal hemodynamic responses to these peptides act differently in kidney ...
Mehdi Nematbakhsh
doaj   +1 more source

Bradykinin receptors as a therapeutic target

Expert Opinion on Therapeutic Targets, 2003
Biologically-active kinins, including bradykinin (BK) and Lys(0)-BK (kallidin), are short-lived peptide mediators predominantly generated by the enzymatic action of kallikreins on kininogen precursors. A diverse spectrum of physiological and pathological actions attributed to local kinin production is a consequence of the activation of G-protein ...
Howl, John D., Payne, Sarah J.
openaire   +4 more sources