Results 41 to 50 of about 21,207 (157)

QSAR based modeling on a series of α-hydroxy amides as a novel class of bradykinin B1 selective antagonists

Journal of Saudi Chemical Society, 2010
G-protein coupled receptors like Bradykinin (BK) B1 represent a potential treatment route for chronic pain and inflammation. Quantitative structure activity relationship has been performed on a series of α-hydroxy amides as a novel class of bradykinin B1
A.K. Srivastava, Neerja Shukla, Avni Pandey, Akanchha Srivastava   +3 more
doaj   +1 more source

Bradykinin Receptors in Metabolic Disorders: A Comprehensive Review

Drugs and Drug Candidates
The kallikrein–kinin system and its B1 and B2 receptors are key regulators in metabolic disorders such as obesity, diabetes, and insulin resistance. Obesity, a chronic and multifactorial condition often associated with comorbidities like type 2 diabetes ...
Jéssica Branquinho, Raquel Leão Neves, Michael Bader, João Bosco Pesquero   +3 more
doaj   +1 more source

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Nature Communications, 2018
Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson   +8 more
doaj   +1 more source

Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice

Frontiers in Aging Neuroscience, 2019
Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS)
Mariana Toricelli, Mariana Toricelli, Sebastiana Ribeiro Evangelista, Sebastiana Ribeiro Evangelista, Larissa Rolim Oliveira, Tania Araujo Viel, Tania Araujo Viel, Hudson Sousa Buck, Hudson Sousa Buck   +8 more
doaj   +1 more source

Evaluation of Antioxidant Activity of Methanolic Extracts and some Fractions of Salvia verticillata L. Using Three Different Methods

Journal of Medicinal Plants, 2007
Background: Bradykinin has effects on histaminic response,vessels seepage,cellular reproduction,causing fever, pain and coughs caused by ACE controllers (3,4,6).
E Souri, H Farsam, S Ardestani, M Zolfagharifar   +3 more
doaj  

Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect

International Journal of Hypertension, 2017
Aminopeptidase A (APA) cleaves angiotensin (Ang) II, kallidin, and other related peptides. In the brain, it activates the renin angiotensin system and causes hypertension.
Takuto Nakamura, Masanobu Yamazato, Akio Ishida, Yusuke Ohya   +3 more
doaj   +1 more source

Inhibition of angiotensin converting enzyme increases PKCβI isoform expression via activation of substance P and bradykinin receptors in cultured astrocytes of mice. [PDF]

J Vet Sci, 2023
Choi JG, Choi SR, Kang DW, Shin HJ, Lee M, Hwang J, Kim HW.   +6 more
europepmc   +1 more source

KLK12 Regulates MMP-1 and MMP-9 via Bradykinin Receptors: Biomarkers for Differentiating Latent and Active Bovine Tuberculosis. [PDF]

Int J Mol Sci, 2022
Wang Y, Qu M, Liu Y, Wang H, Dong Y, Zhou X.   +5 more
europepmc   +1 more source

Bradykinin Receptor Modulation in Vein Grafts

Journal of Investigative Surgery, 1994
Following vein grafting, bradykinin B2 receptor-mediated responses in the vein graft are decreased and B1 receptor-mediated responses are increased. It is not known whether these changes in bradykinin receptor responses are due to nonspecific changes, local inflammation, or arterial hemodynamics.
M G, Davies, P O, Hagen
openaire   +2 more sources

Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model. [PDF]

Cell Mol Neurobiol, 2021
Gonçalves ECD, Vieira G, Gonçalves TR, Simões RR, Brusco I, Oliveira SM, Calixto JB, Cola M, Santos ARS, Dutra RC.   +9 more
europepmc   +1 more source