Results 61 to 70 of about 567,455 (203)

The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice

Frontiers in Immunology, 2018
The kallikrein–kinin system (KKS) consists of two serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-molecular-weight kininogen (HK). Upon activation of the KKS, HK is cleaved to release bradykinin.
Bo Wang, Aizhen Yang, Zhenzhen Zhao, Chao He, Yuanyuan Liu, Robert W. Colman, Jihong Dai, Jihong Dai, Yi Wu, Yi Wu   +9 more
doaj   +1 more source

Envolvimento dos receptores B1 e B2 para as cininas na hiperatividade da bexiga urinária induzida por lesão medular em ratos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2011O envolvimento dos receptores B1 e B2 para as cininas em processos fisiopatológicos da bexiga ...
Forner, Stefânia
core  

Bradykinin Receptors in Metabolic Disorders: A Comprehensive Review

Drugs and Drug Candidates
The kallikrein–kinin system and its B1 and B2 receptors are key regulators in metabolic disorders such as obesity, diabetes, and insulin resistance. Obesity, a chronic and multifactorial condition often associated with comorbidities like type 2 diabetes ...
Jéssica Branquinho, Raquel Leão Neves, Michael Bader, João Bosco Pesquero   +3 more
doaj   +1 more source

Bradykinin Receptor Modulation in Vein Grafts

Journal of Investigative Surgery, 1994
Following vein grafting, bradykinin B2 receptor-mediated responses in the vein graft are decreased and B1 receptor-mediated responses are increased. It is not known whether these changes in bradykinin receptor responses are due to nonspecific changes, local inflammation, or arterial hemodynamics.
M G, Davies, P O, Hagen
openaire   +2 more sources

The actions of Pasteurella multocida toxin on neuronal cells [PDF]

, 2014
Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Lax, Alistair; id_orcid, Robbins, Jon, Duricki, DA, Surguy, SM, Duricki, Denise A., Duricki, Denise, Lax, AJ, Reilly, JM, Reilly, Joanne, Surguy, Susan, Surguy, Susan M., Reilly, Joanne M., Robbins, J, Lax, Alistair J.   +13 more
core   +1 more source

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors

Nature Communications, 2018
Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-
Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes, Richard J. A. Wilson   +8 more
doaj   +1 more source

Induction of bradykinin B1 receptor in rats

Folia Pharmacologica Japonica, 1997
We found the time-dependent induction of the systemic hypotensive response to des-Arg9-bradykinin and the contractile response of ileum of rats to des-Arg9-bradykinin. Both induced responses to des-Arg9-bradykinin were inhibited by treatment with a B1 receptor competitive antagonist, while the responses to bradykinin was constant throughout the ...
UENO, Akinori, OH-ISHI, Sachiko
openaire   +2 more sources

Uma Nova visão da participação dos receptores B1 e B2 para cininas na dor neuropática orofacial [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011Embora pouco prevalente entre a população, a neuralgia do trigêmeo é uma das condições mais dolorosas.
Luiz, Ana Paula
core  

Evaluation of Antioxidant Activity of Methanolic Extracts and some Fractions of Salvia verticillata L. Using Three Different Methods

Journal of Medicinal Plants, 2007
Background: Bradykinin has effects on histaminic response,vessels seepage,cellular reproduction,causing fever, pain and coughs caused by ACE controllers (3,4,6).
E Souri, H Farsam, S Ardestani, M Zolfagharifar   +3 more
doaj  

Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice

Frontiers in Aging Neuroscience, 2019
Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS)
Mariana Toricelli, Mariana Toricelli, Sebastiana Ribeiro Evangelista, Sebastiana Ribeiro Evangelista, Larissa Rolim Oliveira, Tania Araujo Viel, Tania Araujo Viel, Hudson Sousa Buck, Hudson Sousa Buck   +8 more
doaj   +1 more source