Results 1 to 10 of about 1,270,647 (242)

Cryo-EM structures of human bradykinin receptor-Gq proteins complexes [PDF]

Nature Communications, 2022
Type 2 bradykinin receptor (B2R) is essential in vasodilation and cardioprotection. Here the authors present two cryo-EM structures of human B2R-Gq in complex with bradykinin and kallidin to elucidate the mechanisms for ligand binding, receptor ...
Jinkang Shen, Dongqi Zhang, Yao Fu, Anqi Chen, Xiaoli Yang, Haitao Zhang   +5 more
doaj   +2 more sources

Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor [PDF]

Frontiers in Medicine, 2019
Atherosclerosis and ensuing cardiovascular disease are major causes of death with insufficient treatment options. In search for pathomechanisms of atherosclerosis, we investigated the impact of the B2 bradykinin receptor, Bdkrb2, on atherosclerotic ...
Alexander Perhal, Stefan Wolf, Yahya F. Jamous, Andreas Langer, Joshua Abd Alla, Ursula Quitterer, Ursula Quitterer   +6 more
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Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation

Cell Reports, 2019
Summary: Activation of Gαq-coupled receptors by inflammatory mediators inhibits cold-sensing TRPM8 channels, aggravating pain and inflammation. Both Gαq and the downstream hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) inhibit TRPM8. Here, I
Xuming Zhang
doaj   +2 more sources

Bradykinin reduces wound healing in human umbilical vein endothelial cells via downregulation of vascular endothelial growth factor A [PDF]

Journal of Inflammation
Introduction Hereditary angioedema (HAE) is characterized by acute swelling attacks triggered by abnormally elevated levels of bradykinin. Despite persistently high bradykinin levels, patients experience only intermittent swelling episodes.
Nevena Dimitrova, Angelina Gierke, Raphael Möhrle, Julia Nemeth, Cornelia Brunner, Thomas K. Hoffmann, Jens Greve, Janina Hahn, Robin Lochbaum   +8 more
doaj   +2 more sources

Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists. [PDF]

PLoS ONE, 2012
Kinins, with bradykinin and des-Arg(9)-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke.
Antonio H Martins, Janaina M Alves, Dinely Perez, Marimeé Carrasco, Wilmarie Torres-Rivera, Vesna A Eterović, Pedro A Ferchmin, Henning Ulrich   +7 more
doaj   +1 more source

Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID-19

Mediators of Inflammation, 2022
The COVID-19 pandemic is rapidly spreading, and health care systems are being overwhelmed with the huge number of cases, with a good number of cases requiring intensive care.
Aisha Tabassum, Mohammad Shahid Iqbal, Sadia Sultan, Raghad Ali Alhuthali, Deena Ismail Alshubaili, Raghad Salah Sayyam, Lama Mohammed Abyad, Ahmed H. Qasem, Ahmad F. Arbaeen   +8 more
doaj   +1 more source

Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice

Nature Communications, 2023
An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, the underlying mechanisms remain incompletely defined.
Fei Xiao, Haizhou Jiang, Zi Li, Xiaoxue Jiang, Shanghai Chen, Yuguo Niu, Hanrui Yin, Yousheng Shu, Bo Peng, Wei Lu, Xiaoying Li, Zhigang Li, Shujue Lan, Xiaoyan Xu, Feifan Guo   +14 more
doaj   +1 more source

Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and -Independent Vasoconstriction in Rat Mesenteric Resistance Arteries

Journal of Pharmacological Sciences, 2004
Mechanisms underlying bradykinin-induced vasoconstriction were investigated in rat perfused mesenteric vascular beds with active tone. In preparations with intact endothelium, bolus injections of bradykinin (1 to 1,000 pmol) dose-dependently produced ...
Hideki Nawa, Yuji Kurosaki, Hiromu Kawasaki   +2 more
doaj   +1 more source

Bradykinin inhibits oxidative stress-induced cardiomyocytes senescence via regulating redox state. [PDF]

PLoS ONE, 2013
BACKGROUND: Cell senescence is central to a large body of age related pathology, and accordingly, cardiomyocytes senescence is involved in many age related cardiovascular diseases.
Ruolan Dong, Xizhen Xu, Geng Li, Wenjing Feng, Gang Zhao, Junjie Zhao, Dao Wen Wang, Ling Tu   +7 more
doaj   +1 more source

Angiotensin-converting enzyme (ACE) I/D and bradykinin B2 receptor T/C genes polymorphism in patients with ACE inhibitors-related cough

Egyptian Journal of Medical Human Genetics, 2018
Background: Angiotensin-converting enzyme (ACE) inhibitors-related cough had been reported to contribute for discontinuation of ACE inhibitors therapy.
Mohammad Saifur Rohman, Jonny Karunia Fajar, Bagus Hery Kuncahyo, Lowry Yunita, Erdo Puncak Sidarta, Putu Nina Belinda Saka, Teuku Heriansyah, Nashi Widodo   +7 more
doaj   +1 more source