Results 1 to 10 of about 25,846 (162)

Cryo-EM structures of human bradykinin receptor-Gq proteins complexes [PDF]

Nature Communications, 2022
Type 2 bradykinin receptor (B2R) is essential in vasodilation and cardioprotection. Here the authors present two cryo-EM structures of human B2R-Gq in complex with bradykinin and kallidin to elucidate the mechanisms for ligand binding, receptor ...
Jinkang Shen, Dongqi Zhang, Yao Fu, Anqi Chen, Xiaoli Yang, Haitao Zhang   +5 more
doaj   +2 more sources

Bradykinin-bradykinin 2 receptor and oxidative stress

Annals of Medicine
Introduction Bradykinin (BK) and its primary receptor, the bradykinin 2 receptor (B2R), play pivotal roles in regulating oxidative stress. While B2R activation has traditionally been linked to elevated reactive oxygen species (ROS) and pro-apoptotic ...
Jun Zhao, Zhuanping Wang, Xuetao Wang, Fangjun Yang, Huirong Xi, Jiantao Wen, Wenjing Zhang, Xiaoming Qiu   +7 more
doaj   +3 more sources

Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor [PDF]

Frontiers in Medicine, 2019
Atherosclerosis and ensuing cardiovascular disease are major causes of death with insufficient treatment options. In search for pathomechanisms of atherosclerosis, we investigated the impact of the B2 bradykinin receptor, Bdkrb2, on atherosclerotic ...
Alexander Perhal, Stefan Wolf, Yahya F. Jamous, Andreas Langer, Joshua Abd Alla, Ursula Quitterer, Ursula Quitterer   +6 more
doaj   +2 more sources

Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation

Cell Reports, 2019
Summary: Activation of Gαq-coupled receptors by inflammatory mediators inhibits cold-sensing TRPM8 channels, aggravating pain and inflammation. Both Gαq and the downstream hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) inhibit TRPM8. Here, I
Xuming Zhang
doaj   +2 more sources

Bradykinin reduces wound healing in human umbilical vein endothelial cells via downregulation of vascular endothelial growth factor A [PDF]

Journal of Inflammation
Introduction Hereditary angioedema (HAE) is characterized by acute swelling attacks triggered by abnormally elevated levels of bradykinin. Despite persistently high bradykinin levels, patients experience only intermittent swelling episodes.
Nevena Dimitrova, Angelina Gierke, Raphael Möhrle, Julia Nemeth, Cornelia Brunner, Thomas K. Hoffmann, Jens Greve, Janina Hahn, Robin Lochbaum   +8 more
doaj   +2 more sources

Association between Toll-like receptor 9 signaling defect and developing post-infectious irritable bowel syndrome [PDF]

Frontiers in Immunology
IntroductionPost-infectious irritable bowel syndrome (PI-IBS) is a functional gastrointestinal disorder that develops after intestinal infection. A follow-up study after a waterborne outbreak of gastroenteritis indicated involvement of specific genetic ...
Satoshi Kotani, Yoshiyuki Mishima, Kenichi Kishimoto, Akihiko Oka, Naoki Oshima, Kousaku Kawashima, Kenjiro Matsumoto, Haruki Usuda, Koichiro Wada, Shunji Ishihara   +9 more
doaj   +2 more sources

Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists. [PDF]

PLoS ONE, 2012
Kinins, with bradykinin and des-Arg(9)-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke.
Antonio H Martins, Janaina M Alves, Dinely Perez, Marimeé Carrasco, Wilmarie Torres-Rivera, Vesna A Eterović, Pedro A Ferchmin, Henning Ulrich   +7 more
doaj   +1 more source

Involvement of bradykinin and bradykinin B1 receptor in patients with endometriosis

Experimental and Therapeutic Medicine, 2021
Endometriosis (EM), a benign aseptic inflammatory disease, is associated with the presence of endometrial foci. Pain, one of its typical symptoms, has been reported as a constant stressor, but the etiology and pathogenesis of EM-associated pain are unclear.
Meng, Xin, Li, Ying, Li, Qingxue, Yang, Jian, An, Mingli, Fu, Xinping, Zhang, Shuancheng, Chen, Jingwei   +7 more
openaire   +3 more sources

Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID-19

Mediators of Inflammation, 2022
The COVID-19 pandemic is rapidly spreading, and health care systems are being overwhelmed with the huge number of cases, with a good number of cases requiring intensive care.
Aisha Tabassum, Mohammad Shahid Iqbal, Sadia Sultan, Raghad Ali Alhuthali, Deena Ismail Alshubaili, Raghad Salah Sayyam, Lama Mohammed Abyad, Ahmed H. Qasem, Ahmad F. Arbaeen   +8 more
doaj   +1 more source

Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice

Nature Communications, 2023
An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, the underlying mechanisms remain incompletely defined.
Fei Xiao, Haizhou Jiang, Zi Li, Xiaoxue Jiang, Shanghai Chen, Yuguo Niu, Hanrui Yin, Yousheng Shu, Bo Peng, Wei Lu, Xiaoying Li, Zhigang Li, Shujue Lan, Xiaoyan Xu, Feifan Guo   +14 more
doaj   +1 more source