Results 11 to 20 of about 25,904 (219)

Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and -Independent Vasoconstriction in Rat Mesenteric Resistance Arteries

Journal of Pharmacological Sciences, 2004
Mechanisms underlying bradykinin-induced vasoconstriction were investigated in rat perfused mesenteric vascular beds with active tone. In preparations with intact endothelium, bolus injections of bradykinin (1 to 1,000 pmol) dose-dependently produced ...
Hideki Nawa, Yuji Kurosaki, Hiromu Kawasaki   +2 more
doaj   +1 more source

Bradykinin inhibits oxidative stress-induced cardiomyocytes senescence via regulating redox state. [PDF]

PLoS ONE, 2013
BACKGROUND: Cell senescence is central to a large body of age related pathology, and accordingly, cardiomyocytes senescence is involved in many age related cardiovascular diseases.
Ruolan Dong, Xizhen Xu, Geng Li, Wenjing Feng, Gang Zhao, Junjie Zhao, Dao Wen Wang, Ling Tu   +7 more
doaj   +1 more source

Angiotensin-converting enzyme (ACE) I/D and bradykinin B2 receptor T/C genes polymorphism in patients with ACE inhibitors-related cough

Egyptian Journal of Medical Human Genetics, 2018
Background: Angiotensin-converting enzyme (ACE) inhibitors-related cough had been reported to contribute for discontinuation of ACE inhibitors therapy.
Mohammad Saifur Rohman, Jonny Karunia Fajar, Bagus Hery Kuncahyo, Lowry Yunita, Erdo Puncak Sidarta, Putu Nina Belinda Saka, Teuku Heriansyah, Nashi Widodo   +7 more
doaj   +1 more source

The des-Arg9-bradykinin/B1R axis: Hepatic damage in COVID-19

Frontiers in Physiology, 2022
Patients infected by the SARS-CoV-2 virus are commonly diagnosed with threatening liver conditions associated with drug-induced therapies and systemic viral action.
Gabriel Moreira de M Mendes, Gabriel Moreira de M Mendes, Israel Júnior Borges Do Nascimento, Israel Júnior Borges Do Nascimento, Paulo HS. Marazzi-Diniz, Izabela B. Da Silveira, Izabela B. Da Silveira, Matheus F. Itaborahy, Matheus F. Itaborahy, Luiz E. Viana, Luiz E. Viana, Filipe A. Silva, Monique F Santana, Rebecca AA. Pinto, Bruna G. Dutra, Marcus Vinicius G. Lacerda, Stanley A. Araujo, David Wanderley, Paula VT. Vidigal, Paulo HC Diniz, Thiago Verano-Braga, Robson AS. Santos, M Fatima Leite   +22 more
doaj   +1 more source

Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis

Frontiers in Pharmacology, 2018
Bone marrow metastasis occurs in approximately 350,000 patients that annually die in the U.S. alone. In view of the importance of tumor cell migration into the bone marrow, we have here investigated effects of various concentrations of stromal cell ...
Henning Ulrich, Mariusz Z. Ratajczak, Mariusz Z. Ratajczak, Gabriela Schneider, Elena Adinolfi, Elisa Orioli, Enéas G. Ferrazoli, Talita Glaser, Juliana Corrêa-Velloso, Poliana C. M. Martins, Fernanda Coutinho, Ana P. J. Santos, Micheli M. Pillat, Ulrich Sack, Claudiana Lameu   +14 more
doaj   +1 more source

Bradykinin receptors in intestinal smooth muscles and their post-receptor events related to calcium

Mediators of Inflammation, 1993
The effects of trifluoperazine and verapamil on bradykinin- and des-Arg9-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events.
Yusuf Öztürk, V. Melih Altan, Nuray Yıdızoğlu-Arı, Orhan Altınkurt   +3 more
doaj   +1 more source

Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax plancyi fukienensis: A Prototype of a Novel Class of Bradykinin B2 Receptor Antagonist Peptide from Ranid Frogs

The Scientific World Journal, 2014
The defensive skin secretions of many amphibians are a rich source of bradykinins and bradykinin-related peptides (BRPs). Members of this peptide group are also common components of reptile and arthropod venoms due to their multiple biological functions
Jie Ma, Yu Luo, Lilin Ge, Lei Wang, Mei Zhou, Yingqi Zhang, Jinao Duan, Tianbao Chen, Chris Shaw   +8 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Roles for the Kallikrein-Kinin System in Inflammatory Exudation and Pain: Lessons From Studies on Kininogen-Deficient Rats

Journal of Pharmacological Sciences, 2003
: Roles for the kallikrein-kinin system in inflammation have been investigated extensively, and many reviews on this topic have been published during the 50 years since the discovery of bradykinin in 1949. Recent progress in the field has been remarkable
Akinori Ueno, Sachiko Oh-ishi
doaj   +1 more source

P4.11 LOWER LIMB VASOMOTOR AND FIBRINOLYTIC EFFECTS OF KININ RECEPTOR AGONISTS IN MAN

Artery Research, 2009
Background: Vascular B1 kinin receptor expression is upregulated in human atheroma and the presence of angiotensin-converting enzyme inhibition (ACEi), but its role in man remains unclear.
N.L. Cruden, N.N. Lang, T.J. MacGillivray, N.G. Uren, K.A. Fox, D.E. Newby   +5 more
doaj   +1 more source