Results 31 to 40 of about 1,270,647 (242)
Journal of Translational Medicine, 2009 Background The intravenous co-infusion of labradimil, a metabolically stable bradykinin B2 receptor agonist, has been shown to temporarily enhance the transvascular delivery of small chemotherapy drugs, such as carboplatin, across the blood-brain tumor ...
Glen Daniel +7 more
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Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer's patients
Neurobiology of Disease, 2020 Alzheimer's disease (AD) is characterized by the presence of proteinaceous brain deposits, brain atrophy, vascular dysfunction, and chronic inflammation.
Pradeep K. Singh +4 more
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Drug-induced visceral angioedema [PDF]
Journal of Community Hospital Internal Medicine Perspectives, 2014 Angioedema associated with angiotensin converting enzyme inhibitors (ACEIs) is due to the accumulation of bradykinin and its metabolites. Angiotensin receptor blockers (ARBs) produce anti-hypertensive effects by blocking the angiotensin II AT1 receptor ...
Prashanth M. Thalanayar +4 more
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Die Funktion der Helix 8 für die Regulation des Bradykinin B2 Rezeptors [PDF]
, 2012 Upon activation the human bradykinin B2 receptor (B2R) acts as guanine nucleotide exchange factor for the G proteins Gq/11 and Gi. Thereafter, it gets phosphorylated by G protein-coupled receptor kinases (GRKs) and recruits beta-arrestins, which block ...
Feierler, Jens
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Bradykinin B2 receptor blockade and intradialytic hypotension
BMC Nephrology, 2023 Introduction Intradialytic hypotension (IDH) is a common clinical complication and is associated with increased morbidity and mortality in patients undergoing maintenance hemodialysis (MHD).
Jorge L. Gamboa +6 more
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Can’t Intubate, Can’t Oxygenate: A Rare Case of a Difficult Airway due to Nonhereditary Angioedema
Acta Clinica Croatica, 2022 Angioedema is a form of allergic mediated by histamine and non-allergic mediated by bradykinin and can be lethal if not recognized and treated promptly.
Điđi Delalić +2 more
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The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin [PDF]
, 2002 The influence of the hyaluronanbinding protease (PHBSP), a plasma enzyme with FVII- and pro-urokinase-activating potency, on components of the contact phase (kallikrein/kinin) system was investigated.
Fink, E. +4 more
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Relaxant Effect of Prostaglandin D2–Receptor DP Agonist on Liver Myofibroblast Contraction
Journal of Pharmacological Sciences, 2011 .: Increased intrahepatic resistance causes portal hypertension in cirrhosis. Liver myofibroblasts (MFs) are now regarded as the principle cells involved in sinusoidal blood flow regulation.
Tomoharu Maruyama +4 more
doaj +1 more source
Heliyon, 2023 Bisphenol-A (BPA) is a synthetic chemical compound broadly used in the plastic and epoxy resin industries with a considerable potential for food contamination. Literary reports have suggested that the altered renin-angiotensin system (RAS) is a mechanism
Ahmed A. Morsi +11 more
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Bradykinin increases resensitization of purinergic receptor signaling in glioma cells
Cancer Cell International, 2010 Background Purinergic receptor-mediated signaling plays an important role in the function of glial cells, including glial tumor cells. Bradykinin is also an important paracrine mediator which is highly expressed in brain tumors and may correlate with ...
Brennan Kevin C +3 more
doaj +1 more source