Results 31 to 40 of about 6,579 (265)
Frontiers in Molecular Biosciences, 2020 Cisplatin is a highly effective chemotherapeutic agent. However, its use is limited by nephrotoxicity. Enalapril is an angiotensin I-converting enzyme inhibitor used for the treatment of hypertension, mainly through the reduction of angiotensin II ...
Gabriel R. Estrela +16 more
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A New Radioimmunoassay for Kinins and It's Application for the Measurement of Urinary Kinins and Kallikrein Activity [PDF]
, 1981 By using anti-synthetic bradykinin （BK） antibody in combination with 125I-tyrosyl-bradykinin, a sensitive and specific radioimmunoassay method for urinary kinins has been developed, and a simplified assay system for the measurement of urinary kallikrein ...
田中, 繁道, 島本, 和明
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Kinin Receptor Antagonists as Potential Neuroprotective Agents in Central Nervous System Injury
Molecules, 2010 Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and
Anna V Leonard +3 more
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Kinins: Locally formed peptides during inflammation with potential use in tissue regeneration
, 2023 Kinins are a set of peptides present in tissues and involved in cardiovascular regulation, inflammation, and pain.
Pesquero, J.B., Martins, L., Bader, M.
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Brazilian Journal of Medical and Biological Research, 1998 Low and high molecular weight kininogens (LK and HK), containing 409 and 626 amino acids with masses of ~65 and 120 kDa after glycosylation, respectively, are coded by a single gene mapped to the human chromosome 3 by alternative splicing of the ...
D. Veloso
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Deletion of Kinin B2 Receptor Alters Muscle Metabolism and Exercise Performance. [PDF]
PLoS ONE, 2015 Metabolic syndrome is a cluster of metabolic risk factors such as obesity, diabetes and cardiovascular diseases. Mitochondria is the main site of ATP production and its dysfunction leads to decreased oxidative phosphorylation, resulting in lipid ...
Felipe C G Reis +14 more
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Intensive Care Medicine Experimental, 2019 Background Kinins are short peptides with a wide range of proinflammatory properties that are generated from kininogens in the so-called kallikrein-kinin system.
Chao Ding +3 more
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EVIDENCE FOR RENAL KININS AS MEDIATORS OF AMINO-ACID INDUCED HYPERPERFUSION AND HYPERFILTRATION IN THE RAT [PDF]
, 1992 This study examined the role of tissue kallikrein and kinins in renal vasodilation produced by infusion of amino acids (AA). In rats fed a 9% protein diet for 2 wk, intravenous infusion of a 10% AA solution over 60-90 min reduced total renal vascular ...
SILVA, RH +6 more
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Frontiers in Medicine, 2019 Kallikrein-K1 is the main kinin-forming enzyme in organs in resting condition and in several pathological situations whereas angiotensin I-converting enzyme/kininase II (ACE) is the main kinin-inactivating enzyme in the circulation.
Francois Alhenc-Gelas +6 more
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Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19
Scientific Reports, 2021 The outbreak of COVID-19 has raised interest in the kinin–kallikrein system. Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the active kinin des-Arg(9)-bradykinin, which thus increasingly activates bradykinin receptors known
Tanja Gangnus, Bjoern B. Burckhardt
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