Results 31 to 40 of about 20,465 (247)
BioMed Research International, 2013 The aim of our study was to monitor serum levels of two miRNAs (miR-21 and miR-141) and three KLKs (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy, in order to characterize their fluctuations after surgery.
Maria Giulia Egidi +6 more
semanticscholar +1 more source
Matrix Biology Plus, 2020 As the outermost layer of the skin, the epidermis is playing a major role in organism homeostasis providing the first barrier against external aggressions.
Pauline Nauroy, Alexander Nyström
doaj +1 more source
THE LYMPH SELF ANTIGEN REPERTOIRE
Frontiers in Immunology, 2013 The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature.
Laura eSantambrogio, Cristina eClement
doaj +1 more source
Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. [PDF]
PLoS ONE, 2014 The kallikrein-kinin system (KKS) comprises a cascade of proteolytic enzymes and biogenic peptides that regulate several physiological processes. Over-expression of tissue kallikrein-1 and modulation of the KKS shows beneficial effects on insulin ...
Lilia Maneva-Radicheva +9 more
doaj +1 more source
Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress. [PDF]
PLoS ONE, 2013 Previously we have shown that kallikreins (klks) play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs) as vehicles to deliver klks into the injured kidneys and have measured their ...
Yajuan Li +11 more
doaj +1 more source
BMC Research Notes, 2019 Objective We recently investigated the pathways of immunoreactive bradykinin (iBK) formation in fresh blood of normal volunteers and of patients with hereditary angioedema due to C1-esterase inhibitor deficiency (HAE-1/-2).
François Marceau +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Journal of Gynecologic Oncology, 2012 Objective To determine the predictive accuracy of the combined panels of serum human tissue kallikreins (hKs) and CA-125 for the detection of epithelial ovarian cancer.
Stephen C. L. Koh +12 more
semanticscholar +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Human tissue kallikreins: physiologic roles and applications in cancer.
Molecular Cancer Research, 2004 Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases and are present in at least six mammalian orders. In humans, tissue kallikreins (hK) are encoded by 15 structurally similar, steroid hormone-regulated genes (KLK ...
C. Borgoño +2 more
semanticscholar +1 more source