Visualisation of tissue kallikrein, kininogen and kinin receptors in human skin following trauma and in dermal diseases [PDF]
, 2004 During dermal injury and inflammation the serine proteases kallikreins cleave endogenous, multifunctional substrates (kininogens) to form bradykinin and kallidin.
Bhoola, Kanti D. +7 more
core +1 more source
Kallikreins as Biomarkers for Prostate Cancer
BioMed Research International, 2014 The introduction of testing for prostate-specific antigen (PSA), a member of the fifteen-gene family of kallikrein-related peptidases and also known as kallikrein-related peptidase 3 (KLK3), in blood has revolutionized both the detection and management ...
S. Hong
semanticscholar +1 more source
Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics [PDF]
, 2019 Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR ...
Beattie, Bradley J. +10 more
core +2 more sources
Matrix Biology Plus, 2020 As the outermost layer of the skin, the epidermis is playing a major role in organism homeostasis providing the first barrier against external aggressions.
Pauline Nauroy, Alexander Nyström
doaj +1 more source
Huma man Tiss ssue Kallikreins – A Famil ily with ma many surprises [PDF]
Türk Biyokimya Dergisi, 2006 The hu human tissue kallikreins (KLKs) form a family of 15 closely related serine proteases. They are encoded by conserved genes tandemly located in a large gene clu luster (320 kb) on chromosome 19q13.4.
Tove I. Klokk +2 more
doaj
Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. [PDF]
PLoS ONE, 2014 The kallikrein-kinin system (KKS) comprises a cascade of proteolytic enzymes and biogenic peptides that regulate several physiological processes. Over-expression of tissue kallikrein-1 and modulation of the KKS shows beneficial effects on insulin ...
Lilia Maneva-Radicheva +9 more
doaj +1 more source
THE LYMPH SELF ANTIGEN REPERTOIRE
Frontiers in Immunology, 2013 The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature.
Laura eSantambrogio, Cristina eClement
doaj +1 more source
Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress. [PDF]
PLoS ONE, 2013 Previously we have shown that kallikreins (klks) play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs) as vehicles to deliver klks into the injured kidneys and have measured their ...
Yajuan Li +11 more
doaj +1 more source
Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]
, 2010 Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Debela +21 more
core +1 more source
T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]
, 2008 Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Geissler, Claudia +6 more
core +1 more source