Results 51 to 60 of about 3,839 (199)

Bioactive Gold Plasmonic Interfaces Meet Artificial Intelligence: Advancing Saliva‐Based Surface‐Enhanced Raman Spectroscopy Diagnostics

open access: yesSmall, EarlyView.
ABSTRACT Bioactive gold plasmonic nanostructures are enabling non‐invasive saliva diagnostics by amplifying weak Raman signals and converting complex biofluid chemistry into information‐rich spectral fingerprints. This Review examines saliva‐based Raman and surface‐enhanced Raman spectroscopy (SERS) integrated with artificial intelligence (AI) from a ...
Ajitesh Dhal   +5 more
wiley   +1 more source

In silico analyses and global transcriptional profiling reveal novel putative targets for Pea3 transcription factor related to its function in neurons.

open access: yesPLoS ONE, 2017
Pea3 transcription factor belongs to the PEA3 subfamily within the ETS domain transcription factor superfamily, and has been largely studied in relation to its role in breast cancer metastasis. Nonetheless, Pea3 plays a role not only in breast tumor, but
Başak Kandemir   +7 more
doaj   +1 more source

Integrative proteomic profiling of extracellular vesicle‐enriched preparations with machine learning identifies disease activity‐associated signatures linked to adverse pregnancy outcomes in systemic lupus erythematosus

open access: yesVIEW, EarlyView.
Integrating cross‐cohort extracellular vesicle proteomics with machine learning identifies a simplified protein signature (AGT, FETUB, SPP2, and FCN3) for adverse pregnancy outcome risk stratification in systemic lupus erythematosus, enabling precise disease‐activity discrimination beyond routine clinical assessment.
Weiwei Shi   +5 more
wiley   +1 more source

Differential Expression of the KLK2 and KLK3 Genes in Peripheral Blood and Tissues Samples of Iranian Patients with Prostate Cancer

open access: yesMedical Laboratory Journal, 2019
Background and Objectives: Prostate cancer is a highly prevalent malignancy with a high mortality rate in men. Many studies have investigated the diagnostic value of various genes involved in prostate cancer, but there is no data for Kallikrein 2 (KLK2 ...
Hadis Musavi   +2 more
doaj  

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

open access: yesIntegrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv   +4 more
wiley   +1 more source

Kallikrein inhibitors.

open access: yesFederation proceedings, 1979
So far the Cl inactivator, alpha 2-macroglobulin, antithrombin III (in the presence of heparin), and alpha 1-antitrypsin have been identified as inhibitors of plasma kallikrein; alpha 1-antitrypsin reacts slowly also with tissue kallikreins. Of the various naturally occurring kallikrein inhibitors the basic trypsin-kallikrein inhibitor of bovine organs,
Fritz, Hans   +2 more
openaire   +2 more sources

Dupilumab in Paediatric Netherton Syndrome: Two Case Reports and a Review of the Literature

open access: yesAustralasian Journal of Dermatology, EarlyView.
ABSTRACT Netherton Syndrome (NS) is a rare genodermatosis characterised by a triad of ichthyosiform erythroderma, an atopic diathesis, and trichorrhexis invaginata, for which no effective management is currently approved in Australia. Dupilumab has demonstrated considerable effectiveness in the treatment of atopic conditions in the paediatric ...
Jacqueline Tu   +5 more
wiley   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

open access: yesAllergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj   +4 more
wiley   +1 more source

Editorial: Kallikrein-kinin system: insights into a multifunctional system

open access: yesFrontiers in Physiology, 2023
Guacyara Motta   +2 more
doaj   +1 more source

The Kallikrein-Kinin System: Current and Future Pharmacological Targets

open access: yesJournal of Pharmacological Sciences, 2005
The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and
Marie Eve Moreau   +5 more
doaj   +1 more source

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