Results 61 to 70 of about 3,839 (199)
In Vitro Modeling of Bradykinin-Mediated Angioedema States
Pharmaceuticals, 2020 Kinins (peptides related to bradykinin, BK) are formed from circulating substrates, the kininogens, by the action of two proteases, the kallikreins.
François Marceau +4 more
doaj +1 more source
Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures
Allergy, EarlyView.This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally +6 more
wiley +1 more source
Caveolin-1-Mediated Expression and Secretion of Kallikrein 6 in Colon Cancer Cells
Neoplasia: An International Journal for Oncology Research, 2008 Kallikreins are secreted proteases that may play a functional role and/or serve as a serum biomarker for the presence or progression of certain types of cancers.
Rebecca S. Henkhaus +5 more
doaj +1 more source
Andrology, EarlyView.ABSTRACT Background Klinefelter syndrome is associated with a markedly increased risk of venous thrombosis. While hypogonadism and metabolic dysfunction are known contributors, the role of the contact activation system in Klinefelter syndrome remains unexplored.
Simon Chang +4 more
wiley +1 more source
The role of PSA density in the follow up of men with a negative MRI in the Göteborg‐2 trial
BJU International, EarlyView.Objectives To assess whether prostate‐specific antigen density (PSAD) stratifies long‐term risk of clinically significant prostate cancer (csPCa) after a negative magnetic resonance imaging (MRI; Prostate Imaging‐Reporting and Data System score ≤2) and to evaluate the potential of PSAD to guide follow‐up in a screening setting.
Fredrik Möller +8 more
wiley +1 more source
The Scientific World Journal, 2006 The kallikrein-kinin system (KKS) is a complex system produced in various organs. This system includes kininogen (precursor for kinin), kallikreins, and pharmacologically active bradykinin (BK), which is considered to be proinflammatory and/or ...
J. N. Sharma, G.J. AL-Sherif
doaj +1 more source
The PSA test for prostate cancer screening: an abridged Cochrane review
BJU International, EarlyView.Objectives To assess the effects of prostate cancer screening compared to no screening in men with no prior diagnosis of prostate cancer. Methods This systematic review represents an update of a prior Cochrane review from 2013, searching multiple databases up to November 2025. We included randomised controlled trials (RCTs) of prostate cancer screening
Juan V. A. Franco +6 more
wiley +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source