Results 81 to 90 of about 31,265 (333)

Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients [PDF]

, 2015
Background: Dysregulated expression of Kallikrein-related peptidase 6 (KLK6) is a common feature for many human malignancies and numerous studies evaluated KLK6 as a promising biomarker for early diagnosis or unfavorable prognosis.
A Anisowicz, B Klucky, C Bourcier, C Patsis, CA Borgono, CA Borgono, Carola H. Schrader, CD Petraki, Christa Flechtenmacher, CR Leemans, E Foteinou, E Kostareli, E Olkhov-Mitsel, F Ruckert, G Pampalakis, G Pampalakis, G Pampalakis, G Sotiropoulou, GM Yousef, H Nagahara, HV Nathalie, I Prassas, J Bayani, J Bayani, J Bayani, J Bayani, Jochen Hess, JT Kim, K Ogawa, K Oikonomopoulou, Karim Zaoui, KL Drucker, Klaus-Josef Weber, L Seiz, M Gabril, M Niyazi, M Paliouras, M Roesch Ely, M Talieri, Markus Kolb, ML Gillison, N Michel, NA Franken, NA Ignatenko, NA Ignatenko, Niels Grabe, NM White, NM White, O Schmalhofer, P Kountourakis, Peter K. Plinkert, RS Henkhaus, S Ishige, S Krenzer, S Sun, S Warrier, SI Pai, TF Chow, Thomas Hielscher, U Breitenbach, X Liu, Y Yamano   +61 more
core   +1 more source

In silico analyses and global transcriptional profiling reveal novel putative targets for Pea3 transcription factor related to its function in neurons.

PLoS ONE, 2017
Pea3 transcription factor belongs to the PEA3 subfamily within the ETS domain transcription factor superfamily, and has been largely studied in relation to its role in breast cancer metastasis. Nonetheless, Pea3 plays a role not only in breast tumor, but
Başak Kandemir, Ugur Dag, Burcu Bakir Gungor, İlknur Melis Durasi, Burcu Erdogan, Eray Sahin, Ugur Sezerman, Isil Aksan Kurnaz   +7 more
doaj   +1 more source

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation [PDF]

, 2012
ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously expressed and cleaves membrane proteins, such as epidermal growth factor receptor (EGFR) ligands, l-selectin, and TNF, from the cell surface, thus regulating responses to tissue injury and ...
Blobel, C.P., Bruckner-Tuderman, L., Cobzaru, C., Franzke, C.W., Horiuchi, K., Kurz, T., Loffek, S., Rooijen, N. van, Threadgill, D.W., Triantafyllopoulou, A.   +9 more
core   +1 more source

Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis

Allergy, EarlyView.
ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki, Kazunari Sugita, Zenas Yiu, Sandra Díez‐Ribas, Irene Garcia‐Jimenez, Emma Guttman‐Yassky, Luis F. Santamaria‐Babí   +6 more
wiley   +1 more source

Caveolin-1-Mediated Expression and Secretion of Kallikrein 6 in Colon Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2008
Kallikreins are secreted proteases that may play a functional role and/or serve as a serum biomarker for the presence or progression of certain types of cancers.
Rebecca S. Henkhaus, Upal Kunal Basu Roy, Dora Cavallo-Medved, Bonnie F. Sloane, Eugene W. Gerner, Natalia A. Ignatenko   +5 more
doaj   +1 more source

Contact Activation Is Alleviated by Testosterone Replacement Therapy in Klinefelter Syndrome: Evidence of Hormonal and Metabolic Modulation

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome is associated with a markedly increased risk of venous thrombosis. While hypogonadism and metabolic dysfunction are known contributors, the role of the contact activation system in Klinefelter syndrome remains unexplored.
Simon Chang, Claus H. Gravholt, Anne Skakkebæk, Anna‐Marie Bloch Münster, Yaseelan Palarasah   +4 more
wiley   +1 more source

Editorial: Kallikrein-kinin system: insights into a multifunctional system

Frontiers in Physiology, 2023
Guacyara Motta, Luiz Juliano, Zia Shariat-Madar   +2 more
doaj   +1 more source

Pharmacologic Targets and Prototype Therapeutics in the Kallikrein-Kinin System: Bradykinin Receptor Agonists or Antagonists

The Scientific World Journal, 2006
The kallikrein-kinin system (KKS) is a complex system produced in various organs. This system includes kininogen (precursor for kinin), kallikreins, and pharmacologically active bradykinin (BK), which is considered to be proinflammatory and/or ...
J. N. Sharma, G.J. AL-Sherif
doaj   +1 more source

Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. [PDF]

, 2018
OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age.

core   +2 more sources

Specificity Profiling of Seven Human Tissue Kallikreins Reveals Individual Subsite Preferences*

Journal of Biological Chemistry, 2006
Human tissue kallikreins (hKs) form a family of 15 closely related (chymo)trypsin-like serine proteinases. These tissue kallikreins are expressed in a wide range of tissues including the central nervous system, the salivary gland, and endocrine-regulated
M. Debela, V. Magdolen, N. Schechter, M. Valachová, F. Lottspeich, C. Craik, Youngchool Choe, W. Bode, P. Goettig   +8 more
semanticscholar   +1 more source