Results 91 to 100 of about 31,265 (333)

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Activation and enzymatic characterization of recombinant human kallikrein 8 [PDF]

, 2017
Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease.
Cloutier, Sylvain M., Deperthes, David, Diamandis, Eleftherios P., Kishi, Tadaaki, Kündig, Christoph   +4 more
core  

Kallikrein family proteases KLK6 and KLK7 are potential early detection and diagnostic biomarkers for serous and papillary serous ovarian cancer subtypes. [PDF]

, 2014
BACKGROUND: Early detection of ovarian cancer remains a challenge due to widespread metastases and a lack of biomarkers for early-stage disease. This study was conducted to identify relevant biomarkers for both laparoscopic and serum diagnostics in ...
Blake, Patrick, Chirina, Polina, Gharbaran, Rajendra, Goy, Andre, Hu, Wei, Jag, Ushma, Lim, Heejin, Oh Jeong, Jin, Patel, Hiren, Patwa, Ruzeen, Pecora, Andrew, Sarojini, Sreeja, Schindewolf, Craig, Sood, Anil, Suh, K Stephen, Tamir, Ayala, Tanaka, Takemi   +16 more
core   +2 more sources

Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks

Clinical &Experimental Allergy, EarlyView.
In the phase 3 KONFIDENT trial of oral sebetralstat for on‐demand treatment of hereditary angioedema attacks, many attacks induced moderate‐to‐extreme anxiety. Sebetralstat reduced anxiety versus placebo; time to reductions agreed with trial endpoints, such as time to beginning of symptom relief.
Timothy Craig, Emel Aygören‐Pürsün, Jonathan A. Bernstein, Paula J. Busse, Teresa Caballero, Danny M. Cohn, Mar Guilarte, Henriette Farkas, Douglas H. Jones, Sorena Kiani‐Alikhan, Michael E. Manning, Marcus Maurer, Marc A. Riedl, Sinisa Savic, H. James Wedner, Patrick F. K. Yong, Andrea Zanichelli, Sally van Kooten, Matthew Iverson, Erik Hansen, James Hao, Michael D. Smith, Christopher M. Yea, Paul K. Audhya, William R. Lumry   +24 more
wiley   +1 more source

Berotralstat and Health‐Related Quality of Life in Hereditary Angioedema: Pooled Analysis of the APeX‐2 and APeX‐J Trials

Clinical &Experimental Allergy, EarlyView.
Pooled analysis of the phase 3 APeX‐2 and APeX‐J trials evaluated the impact of berotralstat 150 mg on health‐related quality of life in patients with hereditary angioedema using the Angioedema Quality of Life (AE‐QoL) questionnaire. Berotralstat significantly improved AE‐QoL total and domain scores for daily functioning and fears/shame versus placebo ...
Teresa Caballero, Sorena Kiani‐Alikhan, Douglas T. Johnston, Aolin Wang, Lorena Lopez‐Gonzalez, Zheng‐Yi Zhou, Fan Yang, Hannah H. Kim, Sandra Nestler‐Parr, Dianne Tomita, Patrick Gillard, Tamar Kinaciyan   +11 more
wiley   +1 more source

Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals

BMC Genomics, 2010
Background The degradome -the complete repertoire of proteases in an organism- is involved in multiple key biological and pathological processes. Previous studies in several organisms have yielded sets of curated protease sequences which may be used to ...
López-Otín Carlos, Warren Wesley C, Puente Xose S, Velasco Gloria, Quesada Víctor   +4 more
doaj   +1 more source

MSR1 repeats modulate gene expression and affect risk of breast and prostate cancer [PDF]

, 2018
[Background] MSR1 repeats are a 36–38 bp minisatellite element that have recently been implicated in the regulation of gene expression, through copy number variation (CNV).[Patients and methods] Bioinformatic and experimental methods were used to assess ...
Batra, Bhavsar, Borgoño, Cullen, Doolittle, Eatemadi, Ecker, Emami, ENCODE Project Consortium, Graur, Grimwood, Jurka, Jurka, Karolchik, Kerr, Lai, Lose, McLean, Rabien, Rose, Wheeler, Wheeler, Wong, Yousef, Yousef   +24 more
core   +3 more sources

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source

Dysregulated serum levels of human tissue kallikreins, hK7 and hK10, as potential biomarkers of asthma

Biochemistry and Biophysics Reports
Background: Asthma is a highly prevalent inflammatory disease worldwide with limited diagnostic and therapeutic approaches. Objective: This study was conducted to explore the possible role of hK7 and hK10 in asthma progression and evaluate them as ...
Samina Ejaz, Faiz-ul-Hassan Nasim, Iqra Abdullah, Sami Ahmad, Muhammad Ashraf   +4 more
doaj   +1 more source

T Helper 1 and T Helper 2 Cytokines Differentially Modulate Expression of Filaggrin and its Processing Proteases in Human Keratinocytes

Chinese Medical Journal, 2016
Background: Atopic dermatitis (AD) is characterized by defective skin barrier and imbalance in T helper 1/T helper 2 (Th1/Th2) cytokine expression. Filaggrin (FLG) is the key protein to maintaining skin barrier function. Recent studies indicated that Th1/
Zheng-Hong Di, Lei Ma, Rui-Qun Qi, Xiao-Dong Sun, Wei Huo, Li Zhang, Ya-Ni Lyu, Yu-Xiao Hong, Hong-Duo Chen, Xing-Hua Gao   +9 more
doaj   +1 more source