Results 11 to 20 of about 31,265 (333)

Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms. [PDF]

PLoS ONE, 2013
Kallikreins are secreted serine proteases with important roles in human physiology. Human plasma kallikrein, encoded by the KLKB1 gene on locus 4q34-35, functions in the blood coagulation pathway, and in regulating blood pressure.
Vassiliki Lila Koumandou, Andreas Scorilas   +1 more
doaj   +2 more sources

Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model. [PDF]

PLoS ONE, 2011
Human tissue kallikreins (KLKs) are members of a multigene family of serine proteases aberrantly expressed in many cancer types. In ovarian cancer, 12 KLKs are upregulated, and of those KLK5, 6 and 10 have been the focus of investigations into new ...
David Pépin, Zhong-Qi Shao, Geneviève Huppé, Andrea Wakefield, Chee-Wui Chu, Zahra Sharif, Barbara C Vanderhyden   +6 more
doaj   +2 more sources

Evolutionary history of tissue kallikreins. [PDF]

PLoS ONE, 2010
The gene family of human kallikrein-related peptidases (KLKs) encodes proteins with diverse and pleiotropic functions in normal physiology as well as in disease states.
Athanasia Pavlopoulou, Georgios Pampalakis, Ioannis Michalopoulos, Georgia Sotiropoulou   +3 more
doaj   +2 more sources

Gene network analyses point to the importance of human tissue kallikreins in melanoma progression

BMC Medical Genomics, 2011
Background A wide variety of high-throughput microarray platforms have been used to identify molecular targets associated with biological and clinical tumor phenotypes by comparing samples representing distinct pathological states.
Landman Gilles, Rezze Gisele G, Almeida Otávio M, Esteves Gustavo H, Martins Waleska K, Marques Sarah M, Carvalho Alex F, L Reis Luiz F, Duprat João P, Stolf Beatriz S   +9 more
doaj   +2 more sources

Circulating microRNAs and Kallikreins before and after Radical Prostatectomy: Are They Really Prostate Cancer Markers? [PDF]

BioMed Research International, 2013
The aim of our study was to monitor serum levels of two miRNAs (miR-21 and miR-141) and three KLKs (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy, in order to characterize their fluctuations after surgery.
Maria Giulia Egidi, Giovanni Cochetti, M. R. Serva, Gabriella Guelfi, Danilo Zampini, Luca Mechelli, Ettore Mearini   +6 more
openalex   +2 more sources

Kallikreins emerge as new regulators of viral infections

Cellular and Molecular Life Sciences, 2021
Kallikrein-related peptidases (KLKs) or kallikreins have been linked to diverse (patho) physiological processes, such as the epidermal desquamation and inflammation, seminal clot liquefaction, neurodegeneration, and cancer.
G. Pampalakis, E. Zingkou, C. Panagiotidis, G. Sotiropoulou   +3 more
semanticscholar   +1 more source

Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants

Frontiers in Medicine, 2020
Bradykinin (BK)-mediated angioedema (AE) states are rare acquired or hereditary conditions involving localized edema of the subcutaneous and submucosal tissues.
François Marceau, Georges E. Rivard, Julie M. Gauthier, Karen E. Binkley, Arnaud Bonnefoy, Isabelle Boccon-Gibod, Laurence Bouillet, Matthieu Picard, Ghislain Levesque, Hannah Laure Elfassy, Hélène Bachelard, Jacques Hébert, Konrad Bork   +12 more
doaj   +1 more source

Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteome remodelling

Neoplasia: An International Journal for Oncology Research, 2023
Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive and lethal malignancies worldwide with an urgent need for new diagnostic and therapeutic strategies.
Janina Werner, Patrick Bernhard, Miguel Cosenza-Contreras, Niko Pinter, Matthias Fahrner, Prama Pallavi, Johannes Eberhard, Peter Bronsert, Felix Rückert, Oliver Schilling   +9 more
doaj   +1 more source

Co-option of the same ancestral gene family gave rise to mammalian and reptilian toxins

BMC Biology, 2021
Background Evolution can occur with surprising predictability when organisms face similar ecological challenges. For most traits, it is difficult to ascertain whether this occurs due to constraints imposed by the number of possible phenotypic solutions ...
Agneesh Barua, Ivan Koludarov, Alexander S. Mikheyev   +2 more
doaj   +1 more source

Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases

Frontiers in Medicine, 2022
Human tissue Kallikrein-related peptidases (hKLKs) are serine proteases distributed in several tissues that are involved in several biological processes.
Marcelo B. Zani, Aquiles M. Sant'Ana, Rafael C. Tognato, Jair R. Chagas, Luciano Puzer   +4 more
doaj   +1 more source