Results 11 to 20 of about 20,465 (247)

Treatment of hereditary angioedema—single or multiple pathways to the rescue

Frontiers in Allergy, 2022
Hereditary angioedema (HAE) is a rare disease caused by mutations in the SERPING1 gene. This results in deficient or dysfunctional C1 esterase inhibitor (C1-INH) and affects multiple proteases involved in the complement, contact-system, coagulation, and ...
Anna Valerieva, Hilary J. Longhurst
doaj   +1 more source

Interrelation among exercise training, cardiac hypertrophy, and tissue kallikrein-kinin system in athlete and non-athlete women [PDF]

Journal of Cardiovascular and Thoracic Research, 2022
Introduction: The tissue kallikrein-kinin system is an endogenous homeostatic pathway, which its stimulation is associated with cardioprotection. The present study aimed to determine the effect of exercise training on plasma tissue kallikrein (TK) and ...
Behnam Heidari, Mohammad Reza Zolfaghari, Kamal Khademvatani, Amir Fattahi, Reza Zarezadeh   +4 more
doaj   +1 more source

Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers

Molecular Oncology, 2023
Targeted therapies for prostate, breast, and ovarian cancers are based on their activity against primary tumors rather than their anti‐metastatic activity. Consequently, there is an urgent need for new agents targeting the metastatic process.
Amiram Sananes, Itay Cohen, Irit Allon, Oshrit Ben‐David, Raghda Abu Shareb, Ksenia M. Yegodayev, David Stepensky, Moshe Elkabets, Niv Papo   +8 more
doaj   +1 more source

Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants

Frontiers in Medicine, 2020
Bradykinin (BK)-mediated angioedema (AE) states are rare acquired or hereditary conditions involving localized edema of the subcutaneous and submucosal tissues.
François Marceau, Georges E. Rivard, Julie M. Gauthier, Karen E. Binkley, Arnaud Bonnefoy, Isabelle Boccon-Gibod, Laurence Bouillet, Matthieu Picard, Ghislain Levesque, Hannah Laure Elfassy, Hélène Bachelard, Jacques Hébert, Konrad Bork   +12 more
doaj   +1 more source

Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteome remodelling

Neoplasia: An International Journal for Oncology Research, 2023
Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive and lethal malignancies worldwide with an urgent need for new diagnostic and therapeutic strategies.
Janina Werner, Patrick Bernhard, Miguel Cosenza-Contreras, Niko Pinter, Matthias Fahrner, Prama Pallavi, Johannes Eberhard, Peter Bronsert, Felix Rückert, Oliver Schilling   +9 more
doaj   +1 more source

Co-option of the same ancestral gene family gave rise to mammalian and reptilian toxins

BMC Biology, 2021
Background Evolution can occur with surprising predictability when organisms face similar ecological challenges. For most traits, it is difficult to ascertain whether this occurs due to constraints imposed by the number of possible phenotypic solutions ...
Agneesh Barua, Ivan Koludarov, Alexander S. Mikheyev   +2 more
doaj   +1 more source

Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases

Frontiers in Medicine, 2022
Human tissue Kallikrein-related peptidases (hKLKs) are serine proteases distributed in several tissues that are involved in several biological processes.
Marcelo B. Zani, Aquiles M. Sant'Ana, Rafael C. Tognato, Jair R. Chagas, Luciano Puzer   +4 more
doaj   +1 more source

3-Acyltetramic acids as a novel class of inhibitors for human kallikreins 5 and 7.

Bioorganic & Medicinal Chemistry Letters, 2019
Human kallikreins 5 and 7 (KLK5 and KLK7) exhibit trypsin- and chymotrypsin-like activities and are involved in pathologies related to skin desquamation process.
A. D. de Souza, Bárbara Hellen Cabral Pacheco, S. Pinheiro, E. Muri, L. R. Dias, C. H. Lima, R. Garrett, M. M. de Moraes, B. de Souza, L. Puzer   +9 more
semanticscholar   +1 more source

Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19

EBioMedicine, 2022
Summary: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system.
Caroline P. Martens, Pierre Van Mol, Joost Wauters, Els Wauters, Tanja Gangnus, Bernard Noppen, Hanne Callewaert, Jean H.M. Feyen, Laurens Liesenborghs, Elisabeth Heylen, Sander Jansen, Leydi Carolina Velásquez Pereira, Sirima Kraisin, Ipek Guler, Matthias M. Engelen, Anna Ockerman, Anke Van Herck, Robin Vos, Christophe Vandenbriele, Philippe Meersseman, Greet Hermans, Alexander Wilmer, Kimberly Martinod, Bjoern B. Burckhardt, Marc Vanhove, Marc Jacquemin, Peter Verhamme, Johan Neyts, Thomas Vanassche   +28 more
doaj   +1 more source

Salivary kallikrein-8 as a favorable biomarker for stress response [PDF]

Vojnosanitetski Pregled
Background/Aim. Kallikreins (KLKs) are a group of serine protease enzymes capable of cleaving protein peptide bonds. Besides, they are proteolytic enzymes that mediate the conversion of kininogen (alpha 2-globulin) to brady-kinin or kallidin.
Semsi Rabia, Ergunol Erdal, Sepici Dincel Aylin   +2 more
doaj   +1 more source