Results 11 to 20 of about 3,839 (199)

Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants

Frontiers in Medicine, 2020
Bradykinin (BK)-mediated angioedema (AE) states are rare acquired or hereditary conditions involving localized edema of the subcutaneous and submucosal tissues.
François Marceau, Georges E. Rivard, Julie M. Gauthier, Karen E. Binkley, Arnaud Bonnefoy, Isabelle Boccon-Gibod, Laurence Bouillet, Matthieu Picard, Ghislain Levesque, Hannah Laure Elfassy, Hélène Bachelard, Jacques Hébert, Konrad Bork   +12 more
doaj   +1 more source

Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteome remodelling

Neoplasia: An International Journal for Oncology Research, 2023
Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive and lethal malignancies worldwide with an urgent need for new diagnostic and therapeutic strategies.
Janina Werner, Patrick Bernhard, Miguel Cosenza-Contreras, Niko Pinter, Matthias Fahrner, Prama Pallavi, Johannes Eberhard, Peter Bronsert, Felix Rückert, Oliver Schilling   +9 more
doaj   +1 more source

Evolutionary history of tissue kallikreins. [PDF]

PLoS ONE, 2010
The gene family of human kallikrein-related peptidases (KLKs) encodes proteins with diverse and pleiotropic functions in normal physiology as well as in disease states.
Athanasia Pavlopoulou, Georgios Pampalakis, Ioannis Michalopoulos, Georgia Sotiropoulou   +3 more
doaj   +1 more source

Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms. [PDF]

PLoS ONE, 2013
Kallikreins are secreted serine proteases with important roles in human physiology. Human plasma kallikrein, encoded by the KLKB1 gene on locus 4q34-35, functions in the blood coagulation pathway, and in regulating blood pressure.
Vassiliki Lila Koumandou, Andreas Scorilas   +1 more
doaj   +1 more source

Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases

Frontiers in Medicine, 2022
Human tissue Kallikrein-related peptidases (hKLKs) are serine proteases distributed in several tissues that are involved in several biological processes.
Marcelo B. Zani, Aquiles M. Sant'Ana, Rafael C. Tognato, Jair R. Chagas, Luciano Puzer   +4 more
doaj   +1 more source

Co-option of the same ancestral gene family gave rise to mammalian and reptilian toxins

BMC Biology, 2021
Background Evolution can occur with surprising predictability when organisms face similar ecological challenges. For most traits, it is difficult to ascertain whether this occurs due to constraints imposed by the number of possible phenotypic solutions ...
Agneesh Barua, Ivan Koludarov, Alexander S. Mikheyev   +2 more
doaj   +1 more source

Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model. [PDF]

PLoS ONE, 2011
Human tissue kallikreins (KLKs) are members of a multigene family of serine proteases aberrantly expressed in many cancer types. In ovarian cancer, 12 KLKs are upregulated, and of those KLK5, 6 and 10 have been the focus of investigations into new ...
David Pépin, Zhong-Qi Shao, Geneviève Huppé, Andrea Wakefield, Chee-Wui Chu, Zahra Sharif, Barbara C Vanderhyden   +6 more
doaj   +1 more source

Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19

EBioMedicine, 2022
Summary: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system.
Caroline P. Martens, Pierre Van Mol, Joost Wauters, Els Wauters, Tanja Gangnus, Bernard Noppen, Hanne Callewaert, Jean H.M. Feyen, Laurens Liesenborghs, Elisabeth Heylen, Sander Jansen, Leydi Carolina Velásquez Pereira, Sirima Kraisin, Ipek Guler, Matthias M. Engelen, Anna Ockerman, Anke Van Herck, Robin Vos, Christophe Vandenbriele, Philippe Meersseman, Greet Hermans, Alexander Wilmer, Kimberly Martinod, Bjoern B. Burckhardt, Marc Vanhove, Marc Jacquemin, Peter Verhamme, Johan Neyts, Thomas Vanassche   +28 more
doaj   +1 more source

Salivary kallikrein-8 as a favorable biomarker for stress response [PDF]

Vojnosanitetski Pregled
Background/Aim. Kallikreins (KLKs) are a group of serine protease enzymes capable of cleaving protein peptide bonds. Besides, they are proteolytic enzymes that mediate the conversion of kininogen (alpha 2-globulin) to brady-kinin or kallidin.
Semsi Rabia, Ergunol Erdal, Sepici Dincel Aylin   +2 more
doaj   +1 more source

Cutaneous Metastasis of Prostate Adenocarcinoma: A Rare Presentation of a Common Disease

Journal of Investigative Medicine High Impact Case Reports, 2021
Prostate cancer is the most common cancer affecting men in the United States and the second greatest cause of cancer-related death. Metastases usually occur to bone followed by distant lymph nodes and then viscera. Cutaneous metastases are extremely rare.
Alexander Dills BS, Okechukwu Obi MD, Kevin Bustos DO, Jesse Jiang MD, Shweta Gupta MD   +4 more
doaj   +1 more source