Results 21 to 30 of about 20,465 (247)
Cutaneous Metastasis of Prostate Adenocarcinoma: A Rare Presentation of a Common Disease
Journal of Investigative Medicine High Impact Case Reports, 2021 Prostate cancer is the most common cancer affecting men in the United States and the second greatest cause of cancer-related death. Metastases usually occur to bone followed by distant lymph nodes and then viscera. Cutaneous metastases are extremely rare.
Alexander Dills BS +4 more
doaj +1 more source
Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
Frontiers in Physiology, 2023 Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight ...
Guacyara Motta +2 more
doaj +1 more source
Frontiers in Immunology, 2018 Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or −2 only) to ...
Xavier Charest-Morin +5 more
doaj +1 more source
Kallikreins - the melting pot of activity and function
Biochimie, 2015 The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with diverse expression patterns and physiological roles.
M. Kalińska +3 more
semanticscholar +1 more source
Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies
Cells, 2021 The kallikrein-kinin system (KKS) contributes to retinal inflammation and neovascularization, notably in diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD).
Rahmeh Othman +4 more
doaj +1 more source
Biological chemistry, 2014 Recent studies provide a functional link between kallikrein 6 (Klk6) and the development and progression of disease in patients with multiple sclerosis (MS) and in its murine models. To evaluate the involvement of additional kallikrein family members, we
Michael Panos +3 more
semanticscholar +1 more source
Kallikreins as Biomarkers for Prostate Cancer
BioMed Research International, 2014 The introduction of testing for prostate-specific antigen (PSA), a member of the fifteen-gene family of kallikrein-related peptidases and also known as kallikrein-related peptidase 3 (KLK3), in blood has revolutionized both the detection and management ...
S. Hong
semanticscholar +1 more source
Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification
Angewandte Chemie, EarlyView.Bioactive superstructures are assembled via metal–phenolic‐mediated assembly on agarose templates, followed by modification with human serum albumin. These superstructures demonstrate high bilirubin adsorption efficiency, strong antibacterial activity, and anticoagulant activity, providing a strategy for the rational design of multifunctional blood ...
Po Wang +12 more
wiley +2 more sources
Huma man Tiss ssue Kallikreins – A Famil ily with ma many surprises [PDF]
Türk Biyokimya Dergisi, 2006 The hu human tissue kallikreins (KLKs) form a family of 15 closely related serine proteases. They are encoded by conserved genes tandemly located in a large gene clu luster (320 kb) on chromosome 19q13.4.
Tove I. Klokk +2 more
doaj
Drugs of the Kallikrein–Kinin System: An Overview
Drugs and Drug Candidates, 2023 The kallikrein–kinin system consists of the two kininogen substrates present in the blood plasma, and two serine proteases: the plasma and tissue kallikreins.
François Marceau
doaj +1 more source