Results 21 to 30 of about 3,839 (199)
Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
Frontiers in Physiology, 2023 Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight ...
Guacyara Motta +2 more
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Frontiers in Immunology, 2018 Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or −2 only) to ...
Xavier Charest-Morin +5 more
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Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies
Cells, 2021 The kallikrein-kinin system (KKS) contributes to retinal inflammation and neovascularization, notably in diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD).
Rahmeh Othman +4 more
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Angewandte Chemie, EarlyView.Chemical peptide synthesis allows the generation of structurally highly diverse compounds suited for ligand development, but current methods in parallel peptide synthesis limit the achievable library size to a few thousand. A strategy is presented based on combinatorial pairing of short peptides via disulfide linkage that enables the generation and ...
Anne Zarda +5 more
wiley +2 more sources
Huma man Tiss ssue Kallikreins – A Famil ily with ma many surprises [PDF]
Türk Biyokimya Dergisi, 2006 The hu human tissue kallikreins (KLKs) form a family of 15 closely related serine proteases. They are encoded by conserved genes tandemly located in a large gene clu luster (320 kb) on chromosome 19q13.4.
Tove I. Klokk +2 more
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Matrix Biology Plus, 2020 As the outermost layer of the skin, the epidermis is playing a major role in organism homeostasis providing the first barrier against external aggressions.
Pauline Nauroy, Alexander Nyström
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Drugs of the Kallikrein–Kinin System: An Overview
Drugs and Drug Candidates, 2023 The kallikrein–kinin system consists of the two kininogen substrates present in the blood plasma, and two serine proteases: the plasma and tissue kallikreins.
François Marceau
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THE LYMPH SELF ANTIGEN REPERTOIRE
Frontiers in Immunology, 2013 The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature.
Laura eSantambrogio, Cristina eClement
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Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. [PDF]
PLoS ONE, 2014 The kallikrein-kinin system (KKS) comprises a cascade of proteolytic enzymes and biogenic peptides that regulate several physiological processes. Over-expression of tissue kallikrein-1 and modulation of the KKS shows beneficial effects on insulin ...
Lilia Maneva-Radicheva +9 more
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Kallikrein transduced mesenchymal stem cells protect against anti-GBM disease and lupus nephritis by ameliorating inflammation and oxidative stress. [PDF]
PLoS ONE, 2013 Previously we have shown that kallikreins (klks) play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs) as vehicles to deliver klks into the injured kidneys and have measured their ...
Yajuan Li +11 more
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