Results 21 to 30 of about 31,265 (333)

Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19

EBioMedicine, 2022
Summary: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system.
Caroline P. Martens, Pierre Van Mol, Joost Wauters, Els Wauters, Tanja Gangnus, Bernard Noppen, Hanne Callewaert, Jean H.M. Feyen, Laurens Liesenborghs, Elisabeth Heylen, Sander Jansen, Leydi Carolina Velásquez Pereira, Sirima Kraisin, Ipek Guler, Matthias M. Engelen, Anna Ockerman, Anke Van Herck, Robin Vos, Christophe Vandenbriele, Philippe Meersseman, Greet Hermans, Alexander Wilmer, Kimberly Martinod, Bjoern B. Burckhardt, Marc Vanhove, Marc Jacquemin, Peter Verhamme, Johan Neyts, Thomas Vanassche   +28 more
doaj   +1 more source

Development of a Radioimmunoassay for Pig Pancreatic Kallikrein [PDF]

, 1978
Peer ...
Erhardt F., Greenwood F. C, Lemon M., Marschner L, Ole-Moiyoi O., Trautschold I., Tschesche H.   +6 more
core   +2 more sources

Not more than three tissue kallikreins identified from organs of the guinea pig [PDF]

, 1999
The large and varied multigene families of tissue kallikreins of rat and mouse are considered to selectively release as many bioactive peptides. In order to determine whether a similar family of enzymes is expressed in the organs of the guinea pig ...
Geiger, Landmann, Markwardt, Mayer, Oliveira, Pierce, Riegman   +6 more
core   +1 more source

Cutaneous Metastasis of Prostate Adenocarcinoma: A Rare Presentation of a Common Disease

Journal of Investigative Medicine High Impact Case Reports, 2021
Prostate cancer is the most common cancer affecting men in the United States and the second greatest cause of cancer-related death. Metastases usually occur to bone followed by distant lymph nodes and then viscera. Cutaneous metastases are extremely rare.
Alexander Dills BS, Okechukwu Obi MD, Kevin Bustos DO, Jesse Jiang MD, Shweta Gupta MD   +4 more
doaj   +1 more source

Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond

Frontiers in Physiology, 2023
Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight ...
Guacyara Motta, Luiz Juliano, Jair Ribeiro Chagas   +2 more
doaj   +1 more source

Salivary kallikrein-8 as a favorable biomarker for stress response [PDF]

Vojnosanitetski Pregled
Background/Aim. Kallikreins (KLKs) are a group of serine protease enzymes capable of cleaving protein peptide bonds. Besides, they are proteolytic enzymes that mediate the conversion of kininogen (alpha 2-globulin) to brady-kinin or kallidin.
Semsi Rabia, Ergunol Erdal, Sepici Dincel Aylin   +2 more
doaj   +1 more source

Comparing Pathways of Bradykinin Formation in Whole Blood From Healthy Volunteers and Patients With Hereditary Angioedema Due to C1 Inhibitor Deficiency

Frontiers in Immunology, 2018
Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or −2 only) to ...
Xavier Charest-Morin, Jacques Hébert, Georges-Étienne Rivard, Arnaud Bonnefoy, Eric Wagner, François Marceau   +5 more
doaj   +1 more source

Kinins and Their Receptors as Potential Therapeutic Targets in Retinal Pathologies

Cells, 2021
The kallikrein-kinin system (KKS) contributes to retinal inflammation and neovascularization, notably in diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD).
Rahmeh Othman, Gael Cagnone, Jean-Sébastien Joyal, Elvire Vaucher, Réjean Couture   +4 more
doaj   +1 more source

Biochemistry and functional aspects of human glandular kallikreins [PDF]

, 1980
Human urinary kallikrein was purified by gel filtration on Sephacryl S-200 and affinity chromatography on aprotinin-Sepharose, followed by ion exchange chromatography on DEAE-Sepharose.
B. Schütte, Bqruni Förg-Brey, D.E. Fahrney, E. Fink, E. Fink, E. Fink, E.K. Frey, Edwin Fink, F. Fiedler, F. Fiedler, F. Fiedler, G. Dietze, G. Krystal, H. Fritz, H. Rumpelts, H.R. Maurer, I. Trautschold, O.A. Carretero, P. Edman, R. Geiger, R. Geiger, Reinhard Geiger, Ulrike Stuckstedte, W.B. Schill, W.F. Caspary   +24 more
core   +1 more source

Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript [PDF]

, 2011
Genome-wide association studies (GWAS) have identified more than 30 prostate cancer (PrCa) susceptibility loci. One of these (rs2735839) is located close to a plausible candidate susceptibility gene, KLK3, which encodes prostate-specific antigen (PSA)
Kote-Jarai, Z., Amin Al Olama, A., Leongamornlert, D., Tymrakiewicz, M., Saunders, E., Guy, M., Giles, Graham, Severi, G., Southey, M., Hopper, J. L., Sit, K. C., Harris, J. M., Batra, J., Spurdle, A. B., Clements, J. A., Hamdy, Freddie C., Neal, David E., Donovan, Jenny, Muir, Kenneth, Pharoah, P. D. P., Chanock, Stephen, Brown, N., Benlloch, S., Castro, E., Mahmud, N., O'Brien, L., Hall, A., Sawyer, E., Wilkinson, R., Easton, Douglas F., Eeles, Rosalind A.   +30 more
core   +2 more sources