Results 91 to 100 of about 44,865 (239)

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. [PDF]

, 2012
Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we
Barzily-Rokni, Michal, Chapman, Paul B, Cooper, Zachary A, Davis, Ashli, Du, Jinyan, Flaherty, Keith T, Frederick, Dennie T, Golub, Todd R, Gould, Joshua, Lo, Roger S, Mongare, Margaret M, Morikawa, Teppei, Ogino, Shuji, Qian, Zhi Rong, Ribas, Antoni, Shee, Kevin, Solit, David B, Straussman, Ravid, Wargo, Jennifer A   +18 more
core   +1 more source

From mechanism to phenotype: What fits in a basket trial

Epilepsia, EarlyView.
Kette D. Valente
wiley   +1 more source

Can mutation abundance assess the biological behavior of BRAF V600E-positive papillary thyroid carcinoma?

Journal of Translational Medicine
Background BRAF V600E mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAF V600E mutation status and abundance and the biological behavior of PTC is unclear.
Yeqin Ni, Ping Song, Xiangfeng Lin, Jingjing Shi, Qian Shi, Yuanhui Li, Siyu Zhu, Tianhan Zhou, Yanping Xun, Shirong Zhang, Xingchang Ren, Kaining Lu, Fan Wu, Wei Wang, Pan Zhao, Rongjing Zhou, Wenhua Zhang, Dandan Li, Jiaoping Zhang, Chuanghua Chen, Linlin Mao, Li Zhou, Gang Pan, You Peng, Yunxian Yu, Yuying Chen, Rong Ni, Guhan Luo, Yu Zhang, Jugao Fang, Haitao Zheng, Dingcun Luo   +31 more
doaj   +1 more source

Noninvasive prediction of BRAF V600E mutation status of pleomorphic xanthoastrocytomas with MRI morphologic features and diffusion-weighted imaging

BMC Cancer
Objectives Seeking a noninvasive predictor for BRAF V600E mutation status of pleomorphic xanthoastrocytomas (PXAs) is essential for their prognoses and therapeutic use of BRAF inhibitors.
Jing Yan, Cuiping Guo, Hongwei Zheng, Yinhua Li, Mengjiao Duan, Chaoli Zhang, Li Cui, Xiaofei Lv, Gui Fu, Jingliang Cheng   +9 more
doaj   +1 more source

Presence of BRAF V600E Mutation in Nevus Cases

Turkiye Klinikleri Journal of Medical Sciences, 2010
V-raf murine sarcoma viral oncogene homolog B1 (BRAF), belongs to the family of V-RAF-1 murine leukemia viral oncogene homolog 1 (RAF) gene located in the long arm of chromosome 7 (7q34). The BRAF gene encodes a protein that has function in mitogen activated protein kinase (MAPK) signaling pathway with serin/threonin kinase activity.
Çetin, Ayşen, Çoban, Şermin, Çallı Demirkan, Neşe, Şatıroglu Tufan, N. Lale, Tufan, A. Çevik, Bagcı, Hüseyin   +5 more
openaire   +5 more sources

The lincRNA MIRAT binds to IQGAP1 and modulates the MAPK pathway in NRAS mutant melanoma. [PDF]

, 2018
Despite major advances in targeted melanoma therapies, drug resistance limits their efficacy. Long noncoding RNAs (lncRNAs) are transcriptome elements that do not encode proteins but are important regulatory molecules.
Burlingame, Alma, Daud, Adil, Dimon, Michelle, Esteve-Puig, Rosaura, Gajjala, Abhinay, Gho, Deborah, Ho, Wilson, Johnston, Katia, Lai, Kevin, Lin, Kevin, Moy, Adrian, Ortiz-Urda, Susana, Oses Prieto, Juan, Posch, Christian, Rappersberger, Klemens, Sanlorenzo, Martina, Vujic, Igor, Vujic, Marin, Zekhtser, Mitchell   +18 more
core   +1 more source

Frequent oncogenic BRAF V600E mutation in odontogenic keratocyst

Oral Oncology, 2017
Odontogenic keratocyst (OKC), also known as keratocystic odontogenic tumor (KCOT), has clinical significance due to its high incidence as well as high recurrence rate after surgical enucleation. Current clinical management for OCK is entirely dependent on surgical approach.
Yong Hoon Cha, Eunae Sandra Cho, Hee Eun Kang, Jaemin Ko, Woong Nam, Hyung Jun Kim, Nam Hee Kim, Hyun Sil Kim, In-Ho Cha, Jong In Yook   +9 more
openaire   +3 more sources

Utility of Urinary Extracellular Vesicles for Colorectal Cancer: Comparison of DNA Quality and MRD Detection

Cancer Science, EarlyView.
Urinary EVs provide highly pure vesicles with superior DNA quality, making them a robust and completely non‐invasive source for molecular profiling. Urinary EV‐DNA–based MRD assessment shows significant prognostic value and may serve as a practical tool for postoperative monitoring and risk stratification in colorectal cancer.
Shintaro Kanaka, Takeshi Yamada, Fumi Asai, Yuta Shimizu, Kay Uehara, Akihisa Matsuda, Seiichi Shinji, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Kohki Takeda, Sho Kuriyama, Toshimitsu Miyasaka, Koki Hayashi, Hiroshi Yoshida   +14 more
wiley   +1 more source

BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: a histological and molecular analysis focusing on intratumoral heterogeneity [PDF]

, 2019
学位記番号 ...
Nakajima, Nozomi, ナカジマ, ノゾミ, 中島, 希   +2 more
core  

MicroRNA-203 predicts human survival after resection of colorectal liver metastasis. [PDF]

, 2016
BackgroundResection of colorectal liver metastasis (CRLM) can be curative. Predicting which patients may benefit from resection, however, remains challenging. Some microRNAs (miRNAs) become deregulated in cancers and contribute to cancer progression.
D'Angelica, Michael I, Goodarzi, Hani, Jarnagin, William R, Kingham, T Peter, Konstantinidis, Ioannis T, Kuk, Deborah, Nguyen, Hoang CB, Sadot, Eran, Saltz, Leonard, Shia, Jinru, Tavazoie, Sohail F, Zhang, Steven, Zheng, Jian   +12 more
core   +1 more source