Results 131 to 140 of about 44,865 (239)

Pathogenesis of endocrine thyroid cancer [PDF]

, 2015
This review aims to discuss the different genetic alterations that may come about and thus give rise to thyroid cancer. The importance of understanding the pathogenesis of this disease is in the use of these genetic alterations as prognostic markers and ...
Mallia, Nicola, Vassallo, Josanne
core  

Unraveling the nexus: Tumor mutational burden, PD‐L1 expression, and oncogenic alterations in non–small cell lung cancer cytology specimens

Cancer Cytopathology, Volume 134, Issue 4, April 2026.
Abstract Background PD‐L1 expression and tumor mutational burden (TMB) are biomarkers for immune checkpoint inhibitor (ICI) therapy in non–small cell lung cancer (NSCLC); however, patients harboring oncogenic alterations have limited benefit from ICIs.
Min Dai, Francis Anthony San Lucas, Hector Alvarez, Leomar Ballester, Hui Chen, Keyur P. Patel, Asif Rashid, Shun Rao, Mark J. Routbort, Gloria Sura, Keith Sweeney, Gokce Toruner, Peng Wei, Richard Yang, Hyvan Dang, Rajyalakshmi Luthra, Sinchita Roy‐Chowdhuri   +16 more
wiley   +1 more source

A Case of Immunotherapy Response to BRAFV600E‐Mutant Lung Adenocarcinoma With Initial Resistance to Dabrafenib and Trametinib Combination Therapy

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Introduction The recommended first‐line therapy for BRAF V600E mutant non‐small cell lung cancer (NSCLC) is a combination of dabrafenib and trametinib. Most patients respond to the initial therapy, but some show resistance in the early stages.
Yusuke Okayama, Takaaki Tokito, Shizuka Shiraishi, Reiko Takaki, Shingo Tsuneyoshi, Hiroyoshi Yamada, Mamoru Nishiyama, Yoshiko Sueyasu, Tomoaki Hoshino   +8 more
wiley   +1 more source

Clinicopathological Characteristics With the Status of Mismatch Repair Deficient Invasive Colorectal Cancer With Spontaneous Regression

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Spontaneous regression of endoscopically invasive colorectal cancer (CRC) after biopsy has been rarely reported. We report three cases of endoscopically invasive CRC with spontaneous regression after biopsy and a review of the literature regarding spontaneous regression of CRC with somatic mismatch repair deficiency (MMR‐d).
Fumiya Okano, Naohisa Yoshida, Yukiko Morinaga, Naoto Iwai, Reo Kobayashi, Ken Inoue, Osamu Dohi, Takashi Ando, Yoshito Itoh   +8 more
wiley   +1 more source

Conversion Surgery after Chemotherapy in a Stage IV BRAF V600E‐Mutated Laterally Spreading Tumor With Neuroendocrine Component

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT We report a rare case of a BRAF V600E‐mutated laterally spreading tumor, granular type (LST‐G), with a neuroendocrine carcinoma (NEC) component in a patient with stage IV colorectal cancer. The patient presented with multiple lymph nodes and liver metastases.
Reona Kawamura, Naoya Toyoshima, Masau Sekiguchi, Hiroyuki Takamaru, Masayoshi Yamada, Nozomu Kobayashi, Hidekazu Hirano, Yasuyuki Takamizawa, Taiki Hashimoto, Yutaka Saito   +9 more
wiley   +1 more source

Prognostic Implications of Programmed Cell Death Ligand 1 Expression, Cluster of Differentiation 8‐Positive T‐Cell Infiltration, and Related Immunophenotypes in Invasive Mucinous Adenocarcinoma of the Lung: A Multicenter Study

MedComm, Volume 7, Issue 4, April 2026.
An immune phenotype classification for invasive mucinous adenocarcinoma (IMA) was established based on PD‐L1 expression and CD8+ T‐cell infiltration in a large multicenter cohort (n = 312), supplemented by an immunotherapy cohort (n = 20) and single‐cell RNA sequencing analysis.
Guochao Zhang, Chao Zheng, Jia Jia, Xingchen Li, Lide Wang, Long Zhang, Yuzhuo Zhang, Meng Yue, Shuangping Zhang, Yueping Liu, Liyan Xue, Qi Xue, Jie He   +12 more
wiley   +1 more source

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, Volume 268, Issue 4, Page 367-382, April 2026.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source

Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation Testing Trends, Prevalence, and Outcomes in Metastatic, Non‐Squamous Non‐Small Cell Lung Cancer (Non‐SQ NSCLC) Patients in Queensland, Australia From 2014–2023

Thoracic Cancer, Volume 17, Issue 7, April 2026.
KRAS mutations remain the most prevalent oncogenic driver mutation seen in metastatic nonsquamous nonsmall cell lung cancer and a key target for further drug development. This study has highlighted the significant improvement seen in KRAS testing rates over time, with characteristics of Australian KRAS mutant patients corresponding with published ...
Navin Niranjan, Tracey Guan, Nitin Niranjan, Atefeh Taherian Fard, Danny R. Youlden, Robert Mason, Bryan A. Chan, Jasotha Sanmugarajah   +7 more
wiley   +1 more source

Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report [PDF]

, 2019
Callebout, Eduard, Claes, Kathleen, De Man, Marc, Ferdinande, Liesbeth, Geboes, Karen, Laurent, Stéphanie, Moura Ribeiro, Suzane, Van der Meulen, Joni   +7 more
core   +2 more sources

MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX). [PDF]

, 2017
A pancreatic ductal adenocarcinoma (PDAC), obtained from a patient, was grown orthotopically in the pancreatic tail of nude mice to establish a patient-derived orthotopic (PDOX) model.
Bouvet, Michael, Clary, Bryan M, Delong, Jonathan C, Hoffman, Robert M, Hwang, Ho Kyoung, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Lwin, Thinzar M, Murakami, Takashi, Unno, Michiaki   +10 more
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