Results 211 to 220 of about 44,865 (239)
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The Histopathology of BRAF-V600E–mutated Lung Adenocarcinoma
American Journal of Surgical Pathology, 2008BRAF mutations in lung adenocarcinoma are much less common than the more frequently reported and mutually exclusive mutations of KRAS and EGFR genes, and the clinical and histologic phenotype of BRAF adenocarcinomas has not been described. We analyzed 222 adenocarcinomas of lung lacking KRAS and EGFR mutations and identified 10 adenocarcinomas with ...
Samuel A, Yousem +2 more
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Targeting the BRAF V600E Mutation in Multiple Myeloma
Cancer Discovery, 2013Abstract In multiple myeloma, there has been little progress in the specific therapeutic targeting of oncogenic mutations. Whole-genome sequencing data have recently revealed that a subset of patients carry an activating mutation (V600E) in the BRAF kinase.
Mindaugas, Andrulis +12 more
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Braf V600E mutation in melanoma: translational current scenario
Clinical and Translational Oncology, 2016Melanoma was one of the translational cancer examples in clinic, including target therapy related to specific biomarkers impacting in the outcome of melanoma patients. Melanomagenesis involved a wide variety of mutations during his evolution; many of these mutated proteins have a kinase activity.
J A, Guadarrama-Orozco +5 more
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Absence of the BRAF V600E mutation in pheochromocytoma
Journal of Endocrinological Investigation, 2015Pheochromocytomas (PCCs) are rare endocrine tumors originating from the adrenal medulla. These tumors display a highly heterogeneous mutation profile, and a substantial part of the causative genetic events remains to be explained. Recent studies have reported presence of the activating BRAF V600E mutation in PCC, suggesting a role for BRAF activation ...
Johan O, Paulsson +7 more
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We demonstrate here that expression of the oncogenic Raf mutant BRAF V600E results in activation of Akt3.
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Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2015
J. CHANG, Y.P. WANG, C.P. CHIANG
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J. CHANG, Y.P. WANG, C.P. CHIANG
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BRAF V600E mutations in bile duct adenomas
Hepatology, 2014Anaïs, Pujals +9 more
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Vemurafenib in Melanoma with BRAF V600E Mutation
New England Journal of Medicine, 2011Dalle, Stéphane +2 more
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Paradoxical oncogenesis—the long-term effects of BRAF inhibition in melanoma
Nature Reviews Clinical Oncology, 2013Jane L Messina +2 more
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