Results 51 to 60 of about 44,865 (239)

DHODH modulates transcriptional elongation in the neural crest and melanoma [PDF]

, 2011
Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the ...
AD Boiko, AL Rubinstein, AV Molofsky, BR Keegan, Charles Kaufman, Charles Y. Lin, Christopher J. Burke, CT Nguyen, D Mueller, Donna Neuberg, Erin Langdon, Frank Chen, GN Wheeler, Grant N. Wheeler, H Davies, Hannah K. Long, J Tsai, Jack Mosher, JE McLean, Jennifer Cech, K Krishnan, KT Flaherty, Leonard I. Zon, LM Graves, M Löffler, Martin Kramer, Matthew L. Tomlinson, MH Schiff, MJ Kaplan, PB Rahl, Peter B. Rahl, R Luo, Richard A. Young, Richard Mark White, RM Bakos, S Bixby, S Guo, SB Ng, Scott Granter, Sean Morrison, SK Hong, Sumon Datta, Sutheera Ratanasirintrawoot, T Aoki, T Wada, X Bai, Y Chen   +46 more
core   +1 more source

BRAF V600E mutation in Juvenile Xanthogranuloma family neoplasms of the central nervous system (CNS-JXG): a revised diagnostic algorithm to include pediatric Erdheim-Chester disease

Acta Neuropathologica Communications, 2019
The family of juvenile xanthogranuloma family neoplasms (JXG) with ERK-pathway mutations are now classified within the “L” (Langerhans) group, which includes Langerhans cell histiocytosis (LCH) and Erdheim Chester disease (ECD).
J. Picarsic, T. Pysher, H. Zhou, M. Fluchel, T. Pettit, M. Whitehead, L. F. Surrey, B. Harding, G. Goldstein, Y. Fellig, M. Weintraub, B. C. Mobley, P. M. Sharples, M. L. Sulis, E. L. Diamond, R. Jaffe, K. Shekdar, M. Santi   +17 more
doaj   +1 more source

Bendamustine plus rituximab is an effective first-line treatment in hairy cell leukemia variant: A report of three cases [PDF]

, 2017
Hairy cell leukemia variant (HCLv) is a chronic lymphoproliferative disorder classified as a provisional entity in the 2016 WHO Classification of Lymphoid Tumors.
Berno, Tamara, Bertorelle, Roberta, Facco, Monica, Frezzato, Federica, Imbergamo, Silvia, Piazza, Francesco, Piva, Elisa, Pizzi, Marco, Riva, Marcello, Scomazzon, Edoardo, Semenzato, Gianpietro, Trentin, Livio, Visentin, Andrea   +12 more
core   +1 more source

Predicting factors of central lymph node metastasis and BRAF V600E mutation in Chinese population with papillary thyroid carcinoma

World Journal of Surgical Oncology, 2021
Objective The aim of this study was to evaluate the predictive factors of central lymph node metastasis (CLNM) and BRAF V600E mutation in Chinese patients with papillary thyroid carcinoma (PTC).
Sheng Li Zhou, Yan Ping Guo, Lei Zhang, Tao Deng, Zi Guang Xu, Chao Ding, Wen Cong Sun, Yue Wu Zhao, Ling Fei Kong   +8 more
doaj   +1 more source

Clinicopathological Features of Non-Small Cell Lung Carcinoma with BRAF Mutation

Current Oncology, 2023
(1) Background: BRAF mutations affect 4–5% of lung adenocarcinomas. This study aimed to analyze the clinicopathological features of lung carcinomas with BRAF mutations, focusing on V600E vs. non-V600E and the presence of co-mutations.
Andrea Ambrosini-Spaltro, Claudia Rengucci, Laura Capelli, Elisa Chiadini, Daniele Calistri, Chiara Bennati, Paola Cravero, Francesco Limarzi, Sofia Nosseir, Riccardo Panzacchi, Mirca Valli, Paola Ulivi, Giulio Rossi   +12 more
doaj   +1 more source

Reduced expression of THRβ in papillary thyroid carcinomas: relationship with BRAF mutation, aggressiveness and miR expression [PDF]

, 2015
Purpose Down-regulation of thyroid hormone receptor beta (THRβ) gene has been described in several human malignancies, including thyroid cancer. In this study, we analyzed THRβ mRNA expression in surgical specimens from a series of human papillary ...
Celano, M, D'Agostino, M, DI GIOIA, Cira Rosaria Tiziana, Dima, Mariavittoria, Durante, Cosimo, Giacomelli, Laura, Maggisano, V, Pecce, Valeria, Rosignolo, Francesca, Sponziello, Marialuisa, Verrienti, Antonella   +10 more
core   +1 more source

Adult classical glioblastoma with a BRAF V600E mutation [PDF]

World Journal of Surgical Oncology, 2015
The B-Raf proto-oncogene serine/threonine kinase (B-Raf) is a member of the Raf kinase family. The BRAF V600E mutation occurs frequently in certain brain tumors such as pleomorphic xanthoastrocytoma, ganglioglioma, and pilocytic astrocytoma, and less frequently in epithelioid and giant cell glioblastoma.
Takahashi, Yoshinobu, Akahane, Toshiaki, Sawada, Takahiro, Ikeda, Hidetoshi, Tempaku, Akira, Yamauchi, Shigeru, Nishihara, Hiroshi, Tanaka, Shinya, Nitta, Kazumi, Ide, Wataru, Hashimoto, Ikuo, Kamada, Hajime   +11 more
openaire   +2 more sources

Frecuencia de la inmunosupresión de BRAF V600E en ameloblastomas: Un análisis multi-insituticional de 86 casos en América Latina

Odontoestomatología
Objetivos: Investigar la frecuencia de la inmunoexpresión de BRAF V600E en ameloblastomas diagnosticados en cuatro centros de América Latina y correlacionar este hallazgo con los tipos y subtipos histológicos de los casos analizados.
Lauren Frenzel Schuch, Marcela Hernández, Mariana Villarroel-Dorrego, María Luisa Paparella, Nelly Molina-Frechero , Oscar Almeda Ojeda, Vanesa Pereira Prado, Estefanía Sicco, Felipe Martins Silveira, Ronell Bologna-Molina   +9 more
doaj   +1 more source

Clinical and prognostic features of patients with detailed RAS/BRAF-mutant colorectal cancer in Japan

BMC Cancer, 2021
Background RAS/BRAF V600E mutations are the most remarkable oncogenic driver mutations in colorectal cancer (CRC) and play an important role in treatment selection.
Tatsuki Ikoma, Mototsugu Shimokawa, Masahito Kotaka, Toshihiko Matsumoto, Hiroki Nagai, Shogen Boku, Nobuhiro Shibata, Hisateru Yasui, Hironaga Satake   +8 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source