Results 71 to 80 of about 37,133 (255)

CXCL16 promotes tumor metastasis by regulating angiogenesis in the tumor micro-environment of BRAF V600E mutant colorectal cancer

Translational Oncology
Patients of colorectal cancer (CRC) with BRAF V600E mutation obtain poor prognosis. This study aimed to explore the role and mechanism of BRAF V600E mutation in angiogenesis of tumor micro-environment (TME). It has been reported that CXCL16 expression in
Weihao Deng, Xiaoxia Liu, Shuhui Huang, Zhijie Wu, Fichera Alessandro, Qingfeng Lin, Zonglu Cai, Zitong Zhang, Yan Huang, Hui Wang, Zixu Yuan   +10 more
doaj   +1 more source

BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association

Cell Reports, 2018
Summary: Expression of aberrantly spliced BRAF V600E isoforms (BRAF V600E ΔEx) mediates resistance in 13%–30% of melanoma patients progressing on RAF inhibitors. BRAF V600E ΔEx confers resistance, in part, through enhanced dimerization.
Michael J. Vido, Kaitlyn Le, Edward J. Hartsough, Andrew E. Aplin   +3 more
doaj   +1 more source

Concurrent BRAFV600E and BRCA Mutations in MSS Metastatic Colorectal Cancer: Prevalence and Case Series of mCRC patients with prolonged OS

Cancer Treatment and Research Communications, 2022
Background: BRAF V600E+ microsatellite stable (MSS) metastatic colorectal cancer (mCRC) patients comprise up to 10% of advanced CRC. They have a poor prognosis with a median survival typically
Timothy Lewis Cannon, MD., Jamie N Randall, BA., Ethan S. Sokol, PhD., Sonja M. Alexander, Raymond C. Wadlow, MD., Arthur A. Winer, MD., Daniel M. Barnett, MD., Danny L. Rayes, BS., Halla S. Nimeiri, MD., Kimberly A. McGregor, MD   +9 more
doaj   +1 more source

Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]

, 2016
Melanoma is a recalcitrant disease. The present study used a patient-derived orthotopic xenograft (PDOX) model of melanoma to test sensitivity to three molecularly-targeted drugs and one standard chemotherapeutic.
Chmielowski, Bartosz, Dry, Sarah M, Eilber, Fritz C, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Yunfeng, Murakami, Takashi, Nelson, Scott D, Russell, Tara A, Unno, Michiaki   +11 more
core   +1 more source

AlternativeBRAFmutations inBRAFV600E-negative hairy cell leukaemias [PDF]

British Journal of Haematology, 2014
The BRAF V600E mutation in exon 15 is considered the disease-defining mutation in hairy cell leukaemia (HCL), but single HCL cases lacking this mutation have been described. In 24 HCL, as well as in 194 various mature B- and T-cell neoplasms, we extended the search for BRAF mutations to exon 11.
Sebastian, Tschernitz, Lucia, Flossbach, Margrit, Bonengel, Sabine, Roth, Andreas, Rosenwald, Eva, Geissinger   +5 more
openaire   +2 more sources

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

DHODH modulates transcriptional elongation in the neural crest and melanoma [PDF]

, 2011
Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the ...
AD Boiko, AL Rubinstein, AV Molofsky, BR Keegan, Charles Kaufman, Charles Y. Lin, Christopher J. Burke, CT Nguyen, D Mueller, Donna Neuberg, Erin Langdon, Frank Chen, GN Wheeler, Grant N. Wheeler, H Davies, Hannah K. Long, J Tsai, Jack Mosher, JE McLean, Jennifer Cech, K Krishnan, KT Flaherty, Leonard I. Zon, LM Graves, M Löffler, Martin Kramer, Matthew L. Tomlinson, MH Schiff, MJ Kaplan, PB Rahl, Peter B. Rahl, R Luo, Richard A. Young, Richard Mark White, RM Bakos, S Bixby, S Guo, SB Ng, Scott Granter, Sean Morrison, SK Hong, Sumon Datta, Sutheera Ratanasirintrawoot, T Aoki, T Wada, X Bai, Y Chen   +46 more
core   +1 more source

Prognostic Impact of Histologic Subtypes in Mismatch Repair‐Deficient/Microsatellite Instability‐High Colorectal Cancer: A Single‐Center Retrospective Study of 1127 Stage 0–IV Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma, Hirokazu Okayama, Sohei Hayashishita, Hiroya Suzuki, Masanori Katagata, Takuro Matsumoto, Daisuke Ujiie, Shun Chida, Wataru Sakamoto, Koji Kono   +9 more
wiley   +1 more source

Melanoma-Derived BRAF(V600E) Mutation in Peritumoral Stromal Cells: Implications for in Vivo Cell Fusion [PDF]

, 2016
Melanoma often recurs in patients after the removal of the primary tumor, suggesting the presence of recurrent tumor-initiating cells that are undetectable using standard diagnostic methods. As cell fusion has been implicated to facilitate the alteration
Buknicz, Tünde, Dittmar, Thomas, Groma, Gergely, Jakab, Ádám, Kemény, Lajos, Kemény, Lajos Vince, Kurgyis, Zsuzsanna, Németh, István Balázs, Oláh, Judit Magdolna, Polyánka, Hilda, Zänker, Kurt   +10 more
core   +2 more sources

Anaplastic Thyroid Carcinoma Histologically Mimicking a Plasmacytoma. [PDF]

, 2020
Anaplastic (undifferentiated) thyroid carcinoma (ATC) is a rare malignancy which may arise from transformation of a pre-existing differentiated carcinoma. We report the unique case where a lesion of thyroid origin presented with the histological features
Mo, Joshua H, Tan, Donald, Tjoa, Tjoson, Wang, Beverly Y, Zhao, Xiaohui S   +4 more
core   +1 more source