Results 151 to 160 of about 236,444 (370)

Advanced Biomaterial Delivery of Hypoxia‐Conditioned Extracellular Vesicles (EVs) as a Therapeutic Platform for Traumatic Brain Injury

Advanced Science, EarlyView.
This research introduces a novel approach to enhance neuroregeneration following Traumatic Brain Injury (TBI). Extracellular Vesicles (EVs) are isolated from human neural progenitor cells under hypoxic conditions, leading to enhanced expression of neurogenic and angiogenic factors.
Joshua B. Stein, Songzi Zhang, Eun Ji Roh, Jeffrey Luo, Meizi Chen, Hyunjun Jang, Li Ling Goldston, Brandon Conklin, Inbo Han, Ki‐Bum Lee   +9 more
wiley   +1 more source

Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues

Molecules
Microglia, the brain immune cells, support neurons by producing several established neurotrophic molecules including glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF).
Kennedy R. Wiens, Naved Wasti, Omar Orlando Ulloa, Andis Klegeris   +3 more
doaj   +1 more source

Purification and characterisation of a brain‐derived neurotrophic factor/ neurotrophin‐3 (BDNF/NT‐3) heterodimer [PDF]

, 1994
Stefan Jungbluth, Karen A. Bailey, Yves‐Alain Barde   +2 more
openalex   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Advanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang, Jingsong Liu, Pengfei Li, Zhibin Peng, Yubo Zhang, Yishu Liu, Mi Li, Xuqiang Gong, Daqian Liu, Enze Xu, Hongbo Yang, Yuanliang Sun, Yan Xu, Yansong Wang   +13 more
wiley   +1 more source

Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease

Revista Habanera de Ciencias Médicas
Introduction: The brain derived neurotrophic factor is a neurotrophin modulator of cognitive processes. Current studies in Alzheimer’s disease patients show alterations in biomarkers at outlying levels.
Naybí Prendes Rivero, Levis Verde Corvo, Belkis López González, Iris Dany Carmenate Rodríguez, Nibaldo B Mesa Hernández, María A Robinson Agramonte   +5 more
doaj  

Impact of Brain derived Neurotrophic factor gene polymorphism on its peripheral levels in schizophrenic patients

Journal of the Pakistan Medical Association
Objective: To determine serum levels of brain-derived neurotrophic factor and its polymorphism rs12291063 in schizophrenic patients. Method: The case-control study was conducted from January 1, 2020, to May 15, 2021, at Dr Abdul Qadeer Khan Institute ...
Irshad Bibi, Farina Hanif, Quratulain Amir, Washdev Washdev, Mohammad Furqan Bari   +4 more
doaj   +1 more source

Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action

Biological Psychiatry, 2021
E. Castrén, L. Monteggia
semanticscholar   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source

One‐Step Drug Screening System Utilizing Electrophysiological Activity in Multiple Brain Organoids

Advanced Science, EarlyView.
This study presents a one‐step system that delivers different drug doses to brain organoids and monitors their neural activity using integrated 3D microelectrodes. By combining dose‐specific microfluidic delivery with high‐resolution electrophysiological recording, the platform enables simultaneous, real‐time screening of neural responses across ...
Hyogeun Shin, Yeonjoo An, Ju‐Hyun Lee, Ji Hun Kim, Renuka Prasad, Keun‐Tae Kim, Hoon‐Chul Kang, Woong Sun, Seung‐Woo Cho, Il‐Joo Cho   +9 more
wiley   +1 more source

Investigating the Role of BDNF in Insomnia: Current Insights

Nature and Science of Sleep, 2023
Marta Ditmer,* Agata Gabryelska,* Szymon Turkiewicz, Marcin Sochal Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, Lodz, 92-215, Poland*These authors contributed equally to this workCorrespondence: Marcin ...
Ditmer M, Gabryelska A, Turkiewicz S, Sochal M   +3 more
doaj