Results 161 to 170 of about 101,976 (254)

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Therapeutic Effects of MOTS-c in the Valproic Acid-Induced Autism Model in Rats: Role of Tetrahydrobiopterin and Brain-Derived Neurotrophic Factor. [PDF]

Mol Neurobiol
Güvenir Seven S, Sahin H, Erkanlı Şentürk G, Uysal N, Uzun H, Ekici O, Rakıcı G, Şimşek G.   +7 more
europepmc   +1 more source

S1 guideline sweat gland carcinoma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The current classification of sweat gland carcinomas is based on histomorphological characteristics and distinguishes between more than 20 entities. Most patients are older, but some subtypes also affect middle‐aged and younger patients. The majority of tumors arise de novo. Sweat gland carcinomas have nonspecific clinical features.
Mirjana Ziemer, Michael Erdmann, Abbas Agaimy, Jürgen C. Becker, Almut Böer‐Auer, Doris Helbig, Cornelia Erfurt‐Berge, Alexander Frisman, Conrad Hempel, Ulrike Leiter, Friedegund Meier, Thomas Mentzel, Lara Racz, Silke Redler, Stefan Schliep, Clemens Seidel, Alpaslan Tasdogan, Jochen Utikal, Carsten Weishaupt, Selma Ugurel   +19 more
wiley   +1 more source

Cognitive subgroups in bipolar disorder: associations with brain-derived neurotrophic factor and C-reactive protein. [PDF]

BJPsych Open
Demir AM, Görgülü Y, Söğüt K, Palabıyık O, Ayduk Gövdeli E.   +4 more
europepmc   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists and Risk of Mental Health Disorders in Type 2 Diabetes: Active Comparator, New User Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims We evaluated the risk of mental health disorders among glucagon‐like peptide‐1 receptor agonist (GLP1RA) users compared with users of dipeptidyl peptidase‐4 (DPP‐4) inhibitors and sodium‐glucose cotransporter‐2 (SGLT2) inhibitors. Materials and Methods We conducted a nationwide, active‐comparator new‐user cohort study using the Korean ...
Chungsoo Kim, Seonji Kim, Dong Yun Lee, Eugene Han, Yong‐ho Lee, Seng Chan You   +5 more
wiley   +1 more source

MiR-210-3p is upregulated in diabetic peripheral neuropathy and may be involved in the progression of the disease by targeting brain-derived neurotrophic factor. [PDF]

J Diabetes Investig
Zhao Y, Wang L, Feng D.
europepmc   +1 more source

Thriving in Nursing Work: The Association Between Self‐Reports and Biomarkers of Stress, Inflammation and Neuroplasticity

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To examine whether self‐reported thriving at work is associated with biomarkers of stress, inflammation, neuroplasticity and neurodegeneration in nurses. Design A cross‐sectional study. Methods An online questionnaire measuring thriving at work was administered to nurses in a teaching hospital in Michigan, U.S. over 5 weeks in 2024.
Judith E. Arnetz, Eamonn Arble, Jackeline Iseler, Michelle Pena, Nicolina Evola, John Vanschagen, John S. Beck, Scott E. Counts, Bengt B. Arnetz   +8 more
wiley   +1 more source

Efficacy of Adjunct PRObiotics as Compared to the Standard Care in Moderate Unipolar Depression Among Geriatric Patients: A Randomized Double‐Blind Placebo‐Controlled Pilot Multi‐Center Trial (PRODG)

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Objective To evaluate the efficacy of adjunct probiotic supplementation (Lactobacillus helveticus and Bifidobacterium longum) alongside standard care compared to placebo in older adults with moderate unipolar depression. Methods A randomized, double‐blind, placebo‐controlled pilot trial was conducted at two tertiary centers.
Preeti Sinha, Prasun Chatterjee, Preethy Kathiresan, Karishma Sundara Raju, Rasika Panwar, Aparna Mukherjee, Gunjan Kumar, Jerin Jose Cherian, Anoop Velayuthan, Avinash Chakrawarty, Sarnendu Mondal, Manoj Kalita, Spriha Kamboj, Sreyashi Sen, Mounamukhar Bhattacharjee, Manaswini Mondal, Kalyan Bhowmik, Sovonlal Mukherjee, Indranil Saha, Atanu Kumar Dutta, Asim Saha, Amit Chakrabarti, Abhinaba Ghosh, Saibal Das   +23 more
wiley   +1 more source

Function and application of brain‑derived neurotrophic factor precursors (Review). [PDF]

Int J Mol Med
Chen R, Chen W, Li P, Zhao Y, Zeng Q, Chen W, Cao D.   +6 more
europepmc   +1 more source

Cognitive and motor reserve in Parkinson's disease: Two sides of the same coin?

Journal of Neuropsychology, EarlyView.
Abstract Cognitive reserve (CR) and motor reserve (MR) are constructs that can explain why some people are more resilient than others to neurodegenerative diseases such as Parkinson's disease (PD). However, it is unclear whether these reserves exert domain‐specific or cross‐domain influences.
Isabella Anzuino, Sonia Di Tella, Alice Tondinelli, Clio Scopetani Testa, Martina Petracca, Maria Rita Lo Monaco, Anna Rita Bentivoglio, Maria Caterina Silveri   +7 more
wiley   +1 more source