Results 151 to 160 of about 101,976 (254)

Association of Circulating Brain-Derived Neurotrophic Factor With Coronary Risk Factors and Coronary Artery Disease in Patients Who Have Undergone Coronary Computed Tomography Angiography. [PDF]

Cardiol Res
Tachibana T, Shiga Y, Miura-Takahashi E, Tashiro K, Tsudome R, Kawahira Y, Kuwano T, Sugihara M, Imaizumi S, Miura SI.   +9 more
europepmc   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

The role of brain-derived neurotrophic factor in cardiometabolic disease and mental health within the spinal cord injury population: a systematic review. [PDF]

Biomed Eng Online
Walden TP, Cleland M, Tsang P, Main E, Craven BC.   +4 more
europepmc   +1 more source

Priming with interleukin‐1α and chemical hypoxia modulates the mesenchymal stem cell secretome to dampen microglial inflammation and promote neuroprotection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen, Stuart M. Allan, Emmanuel Pinteaux   +2 more
wiley   +1 more source

Brain-derived neurotrophic factor and the derived dodecapeptide function as Toll-like receptor 4 antagonists in acute lung injury. [PDF]

Nat Commun
Zhu W, Jin L, Zhang Q, Cui Y, Zou Y, Chen P, Ye J, Xiong Y, Lin M, Zhou Y, Wu R, Liang Y, Zhuang Z, Huh JY, Luo W, Liang G.   +15 more
europepmc   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Effect of erythropoietin on serum brain-derived neurotrophic factor after experimental traumatic brain injury in Wistar rats: A randomized controlled laboratory study. [PDF]

Surg Neurol Int
Hasan H, Suryaningtyas W, Parenrengi MA, Wungu CDK.   +3 more
europepmc   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

Irisin, Brain-Derived Neurotrophic Factor (BDNF), and Redox Balance in Geriatric Dynapenia. [PDF]

Antioxidants (Basel)
Wojszel A, Śliwowski J, Rentflejsz J, Rogalska J, Brzóska MM, Wojszel ZB.   +5 more
europepmc   +1 more source

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source