Results 181 to 190 of about 92,075 (247)

Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. [PDF]

, 2000
Tsutomu Nakagawa, Atsushi Tsuchida, Y. Itakura, Takeshi Nonomura, Michiko Ono, Fumiko Hirota, Takuro Inoue, C Nakayama, Mutsuo Taiji, Hiroshi Noguchi   +9 more
openalex   +1 more source

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

Movement Disorders, EarlyView.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles, Dilan Athauda, Thomas R. Barber, Roger A. Barker, David T. Dexter, Susan Duty, Romy Ellis‐Doyle, Sonia Gandhi, Joel Handley, Edwin Jabbari, Keith Martin, Kevin McFarthing, Georgia Mills, Heather Mortiboys, Stephen Mullin, Rebecca Petty, Esther Sammler, Paula Scurfield, Simon R.W. Stott, George K. Tofaris, Li Wei, Caroline H. Williams‐Gray, Alan Wong, Marie‐Louise Zeissler, Richard K. Wyse, Camille B. Carroll, Thomas Foltynie, Oliver Bandmann, Anthony H.V. Schapira, on behalf of the EJS ACT‐PD Consortium   +29 more
wiley   +1 more source

A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease [PDF]

, 2000
Hiroshi Kunugi, Akira Ueki, Masakazu Otsuka, Kunihiro Isse, Hideto Hirasawa, Norihiro Kato, T. Nabika, Shotai Kobayashi, Shinichiro Nanko   +8 more
openalex   +1 more source

Intraputaminal Delivery of Adeno‐Associated Virus Serotype 2–Glial Cell Line–Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputaminal infusion in participants with advanced Parkinson's disease (PD) achieved 26% mean putaminal coverage ...
Amber D. Van Laar, Chadwick W. Christine, Nicolás Phielipp, Paul S. Larson, J. Bradley Elder, Aristide Merola, Waldy San Sebastian, Massimo S. Fiandaca, Adrian P. Kells, Michael E. Wisniewski, Krystof S. Bankiewicz   +10 more
wiley   +1 more source

Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis

Neuropsychiatric Disease and Treatment, 2018
Yue-Long Xu,1,* Xiu-Xiu Li,1,* Su-Jing Zhuang,1 Shi-Feng Guo,1 Jian-Ping Xiang,1 Long Wang,2 Lan Zhou,2 Bin Wu3 1Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, China; 2Department of Neurology, Center for Evidence-Based
Xu Y, Li X, Zhuang S, Guo S, Xiang J, Wang L, Zhou L, Wu B   +7 more
doaj  

Brain-Derived Neurotrophic Factor-Mediated Neuroprotection of Adult Rat Retinal Ganglion Cells In Vivo Does Not Exclusively Depend on Phosphatidyl-Inositol-3′-Kinase/Protein Kinase B Signaling [PDF]

, 2000
Nikolaj Klöcker, Pawel Kermer, Jochen H. Weishaupt, Monika Labes, Richard Ankerhold, Mathias Bähr   +5 more
openalex   +1 more source

Neuronally‐Derived Extracellular Vesicles Transforming Growth Factor Beta‐1 Levels in Progressive Supranuclear Palsy

Movement Disorders, EarlyView.
Abstract Background Differentiating progressive supranuclear palsy (PSP) from other parkinsonian disorders may be challenging. Objectives To investigate the role of transforming growth factor beta‐1 (TGFβ1) in PSP. Methods A total of 33 PSP, 39 Parkinson's disease (PD), 8 multiple system atrophy (MSA) patients, and 50 healthy controls (HC) were ...
Selena Mimmi, Elvira Immacolata Parrotta, Anna Maria Tolomeo, Domenico Maisano, Valentina Crapella, Elisabetta Pingitore, Khushboo Fatima, Anna Maria Zimbo, Mariagrazia Talarico, Costanza Maria Cristiani, Luana Scaramuzzino, Desirèe Valente, Clara Zannino, Gianni Cuda, Aldo Quattrone, Enrico Iaccino, Andrea Quattrone   +16 more
wiley   +1 more source

Activity- and Ca2+-Dependent Modulation of Surface Expression of Brain-Derived Neurotrophic Factor Receptors in Hippocampal Neurons [PDF]

, 2000
Jing Du, Linyin Feng, Feng Yang, Bai Lu
openalex   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Advancements in Magnesium Applications, Biocompatible Implants to Nanoparticles in Medicine and Biomedical Innovations

MetalMat, Volume 2, Issue 2, June 2025.
Magnesium (Mg) and its alloys are identified as prospective materials for orthopedic and cardiovascular applications because of their bio‐corrosiveness and ability to stimulate tissue reparative processes. Although compared with traditional metals, Mg is biocompatible; however, it has various problems that stem from its biodegradation nature, for ...
Muhammad Mubeen, Salman Khalid, Mohammad Tabish, Mubashar Mahmood, Muhammad Jawad, Muhammad Uzair Malik, Ghulam Yasin   +6 more
wiley   +1 more source