Results 181 to 190 of about 236,444 (370)

DNA‐Based Hydrogels for Musculoskeletal Reconstruction: Harnessing Dynamic Programmability and Multimodal Therapeutic Integration

Advanced Science, EarlyView.
DNA‐based hydrogels serve dual roles as structural scaffolds and therapeutic platforms, offering innovative solutions for musculoskeletal regeneration with multifunctional abilities. Abstract Musculoskeletal disorders, including bone fractures, osteoarthritis, and muscle injuries, represent a leading cause of global disability, revealing the urgency ...
Ruijianghan Shi, Huilu Zhan, Shan Jiang, Kaili Lin, Changyong Yuan   +4 more
wiley   +1 more source

Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

Journal of Neuroscience, 2002
Y. Shirayama, A. C. Chen, S. Nakagawa, D. Russell, R. Duman   +4 more
semanticscholar   +1 more source

The Survival-Promoting Effect of Glial Cell Line-Derived Neurotrophic Factor on Axotomized Corticospinal NeuronsIn VivoIs Mediated by an Endogenous Brain-Derived Neurotrophic Factor Mechanism [PDF]

, 1998
Klaus M. Giehl, Andreas Schütte, P. Mestres, Qiao Yan   +3 more
openalex   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Single‐Molecule Protein Profiling Using Nanopores and Dimeric Aptamer‐Modified DNA Carriers

Angewandte Chemie, EarlyView.
We developed a nanopore‐based biosensor for single‐molecule protein profiling using aptamer‐modified DNA carrier dimerization strategy, enabling selective and ultrasensitive detection of proteins and protein complexes. This approach promises advances in early‐stage clinical diagnostics and precision medicine.
Xiaoyi Wang, Yaxian Liu, Ren Ren, Joshua B. Edel, Aleksandar P. Ivanov   +4 more
wiley   +2 more sources

Brain Derived Neurotrophic Factor and Exercise [PDF]

Research & Investigations in Sports Medicine, 2018
Kelly Hamilton, Daniel Jaffe, Jennifer Hewit, Jessica Burkett, Alexander Bedard   +4 more
openaire   +1 more source

Treg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR‐Based Genetic Analyses and Experimental Models

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD.
Zuqing Nie, Xinyi Xu, Junhao Chen, Huiling Chen, Meng Li, Yang Zhang, Zhiwei Li, Chen Shen, Jie Wen, Xia Cao   +9 more
wiley   +1 more source

Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons.

, 1994
Axel Leingärtner, Carl‐Philipp Heisenberg, R. Kolbeck, H. Thoenen, Dan Lindholm   +4 more
openalex   +1 more source

t Brain-Derived Neurotrophic Factor Overexpression Induces Precocious Critical Period in Mouse Visual Cortex [PDF]

, 1999
t Jessica L. Hanover, Z. Josh Huang, Susumu Tonegawa, Michael P. Stryker   +3 more
openalex   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source