Results 231 to 240 of about 231,813 (388)

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

Movement Disorders, EarlyView.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles, Dilan Athauda, Thomas R. Barber, Roger A. Barker, David T. Dexter, Susan Duty, Romy Ellis‐Doyle, Sonia Gandhi, Joel Handley, Edwin Jabbari, Keith Martin, Kevin McFarthing, Georgia Mills, Heather Mortiboys, Stephen Mullin, Rebecca Petty, Esther Sammler, Paula Scurfield, Simon R.W. Stott, George K. Tofaris, Li Wei, Caroline H. Williams‐Gray, Alan Wong, Marie‐Louise Zeissler, Richard K. Wyse, Camille B. Carroll, Thomas Foltynie, Oliver Bandmann, Anthony H.V. Schapira, on behalf of the EJS ACT‐PD Consortium   +29 more
wiley   +1 more source

Socioeconomic factors, brain-derived neurotrophic factor Val66Met polymorphism, and cortical structure in children and adolescents. [PDF]

Sci Rep
Merz EC, Morys F, Hansen M, Strack J, Jacobs L, Vainik U, Shishikura M, Myers B.   +7 more
europepmc   +1 more source

TrkB Activation by Brain-derived Neurotrophic Factor Inhibits the G Protein-gated Inward Rectifier Kir3 by Tyrosine Phosphorylation of the Channel [PDF]

, 2000
Sherri L. Rogalski, Suzanne M. Appleyard, Aaron Pattillo, Gregory W. Terman, Charles Chavkin   +4 more
openalex   +1 more source

Intraputaminal Delivery of Adeno‐Associated Virus Serotype 2–Glial Cell Line–Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputaminal infusion in participants with advanced Parkinson's disease (PD) achieved 26% mean putaminal coverage ...
Amber D. Van Laar, Chadwick W. Christine, Nicolás Phielipp, Paul S. Larson, J. Bradley Elder, Aristide Merola, Waldy San Sebastian, Massimo S. Fiandaca, Adrian P. Kells, Michael E. Wisniewski, Krystof S. Bankiewicz   +10 more
wiley   +1 more source

Dual trajectories of serum brain-derived neurotrophic factor and cognitive function in people living with HIV. [PDF]

Sci Rep
Michael HU, Rapulana AM, Smit T, Xulu N, Danaviah S, Ramlall S, Oosthuizen F.   +6 more
europepmc   +1 more source

Neuroprotective effects of glial cell line-derived neurotrophic factor (GDNF) against ischemia-induced brain injury

, 1998
Hiroyuki Miyazaki, Yasunobu Okuma, Yasuyuki Nomura   +2 more
openalex   +1 more source

Cervical Dorsal Rhizotomy Increases Brain-Derived Neurotrophic Factor and Neurotrophin-3 Expression in the Ventral Spinal Cord [PDF]

, 2000
Rebecca A. Johnson, Angela J. Okragly, Mary Haak‐Frendscho, Gordon S. Mitchell   +3 more
openalex   +1 more source

Neuronally‐Derived Extracellular Vesicles Transforming Growth Factor Beta‐1 Levels in Progressive Supranuclear Palsy

Movement Disorders, EarlyView.
Abstract Background Differentiating progressive supranuclear palsy (PSP) from other parkinsonian disorders may be challenging. Objectives To investigate the role of transforming growth factor beta‐1 (TGFβ1) in PSP. Methods A total of 33 PSP, 39 Parkinson's disease (PD), 8 multiple system atrophy (MSA) patients, and 50 healthy controls (HC) were ...
Selena Mimmi, Elvira Immacolata Parrotta, Anna Maria Tolomeo, Domenico Maisano, Valentina Crapella, Elisabetta Pingitore, Khushboo Fatima, Anna Maria Zimbo, Mariagrazia Talarico, Costanza Maria Cristiani, Luana Scaramuzzino, Desirèe Valente, Clara Zannino, Gianni Cuda, Aldo Quattrone, Enrico Iaccino, Andrea Quattrone   +16 more
wiley   +1 more source

Relationship Between Brain-Derived Neurotrophic Factor and Cognitive Function in Methamphetamine-Dependent Patients. [PDF]

Psychiatry Investig
Bae H, Won SD, Kim J, Seo HJ, Han C.
europepmc   +1 more source

Brain‐derived neurotrophic factor blocks long‐term depression in solitary neurones cultured from rat visual cortex

, 2000
Eiji Kumura, Fumitaka Kimura, Nobuaki Taniguchi, Tadaharu Tsumoto   +3 more
openalex   +2 more sources